Patents by Inventor Andrew M. Leach
Andrew M. Leach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8647883Abstract: A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical composition comprising an indicator that changes its optical property in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film.Type: GrantFiled: September 13, 2010Date of Patent: February 11, 2014Assignee: General Electric CompanyInventors: Radislav A. Potyrailo, Timothy M. Sivavec, Caibin Xiao, Theodore J. Cecconie, Lamyaa Hassib, Andrew M. Leach, David B. Engel
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Patent number: 8420025Abstract: Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation.Type: GrantFiled: January 26, 2012Date of Patent: April 16, 2013Assignee: General Electric CompanyInventors: Radislav A. Potyrailo, Prashant V. Shrikhande, Scott M. Boyette, Caibin Xiao, Andrew M. Leach
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Publication number: 20120121466Abstract: Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation.Type: ApplicationFiled: January 26, 2012Publication date: May 17, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Radislav A. Potyrailo, Prashant V. Shrikhande, Scott M. Boyette, Caibin Xiao, Andrew M. Leach
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Patent number: 8133741Abstract: Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation.Type: GrantFiled: August 22, 2006Date of Patent: March 13, 2012Assignee: General Electric CompanyInventors: Radislav A. Potyrailo, Prashant V. Shrikhande, Scott M. Boyette, Caibin Xiao, Andrew M. Leach
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Patent number: 8105552Abstract: Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.Type: GrantFiled: March 24, 2010Date of Patent: January 31, 2012Assignee: General Electric CompanyInventors: Caibin Xiao, Radislav A. Potyrailo, William G. Morris, Scott M. Boyette, LiJie Yu, Theodore J. Cecconie, Andrew M. Leach, Prashant V. Shrikhande
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Publication number: 20110036453Abstract: DNP polarizer comprising a housing receiving a free end of a tubular fluid conduit positioned in fluid communication with a nozzle supported by said housing, said nozzle including an input port, a dispense port and a tapering inner surface or a stepped inner surface defining a nozzle flowpath extending in fluid communication between said input port and said dispense port.Type: ApplicationFiled: August 27, 2008Publication date: February 17, 2011Applicant: GE HEALTHCARE LIMITEDInventors: Jan Henrik Ardenkjaer-larsen, David Dietrich, Karl Andreas Gram, Andrew M. Leach, Peter Miller, Eric J. Telfeyan, Mikkel Thaning, David B. Whitt
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Publication number: 20110014087Abstract: A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical composition comprising an indicator that changes its optical property in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film.Type: ApplicationFiled: September 13, 2010Publication date: January 20, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: Radislav A. Potyrailo, Timothy M. Sivavec, Caibin Xiao, Theodore J. Cecconie, Lamyaa Hassib, Andrew M. Leach, David B. Engel
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Patent number: 7807473Abstract: A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical composition comprising an indicator that changes its optical property in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film.Type: GrantFiled: October 26, 2005Date of Patent: October 5, 2010Assignee: General Electric CompanyInventors: Radislav A. Potyrailo, Timothy M. Sivavec, Caibin Xiao, Theodore J. Cecconie, Lamyaa Hassib, Andrew M. Leach, David B. Engel
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Patent number: 7803320Abstract: A quality control system for measuring parameters in a pharmaceutical product includes a receiver vessel to receive a pharmaceutical product therein. The quality control system also includes a sample tube having a first end attached to the receiver vessel to remove pharmaceutical product from the receiver vessel and an appendage connected to a second end of the sample tube. The appendage includes at least one chamber therein to receive a quantity of pharmaceutical product from the receiver vessel. A valve positioned within the sample tube controls flow of the pharmaceutical product to the appendage and prevents flow of the pharmaceutical product from the appendage back into the receiver vessel. The system also includes a quality control device configured to measure at least one parameter of the pharmaceutical product in at least one of the receiver vessel and the appendage.Type: GrantFiled: May 11, 2007Date of Patent: September 28, 2010Assignee: General Electric CompanyInventors: Peter Miller, Andrew M. Leach, Eric Telfeyan, David B. Whitt
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Publication number: 20100178208Abstract: Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.Type: ApplicationFiled: March 24, 2010Publication date: July 15, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Caibin Xiao, Radislav A. Potyrailo, William G. Morris, Scott M. Boyette, LiJie Yu, Theodore J. Cecconie, Andrew M. Leach, Prashant V. Shrikhande
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Patent number: 7723120Abstract: Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.Type: GrantFiled: October 26, 2005Date of Patent: May 25, 2010Assignee: General Electric CompanyInventors: Caibin Xiao, Radislav A. Potyrailo, William G. Morris, Scott M. Boyette, LiJie Yu, Theodore J. Cecconie, Andrew M. Leach, Prashant V. Shrikhande
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Patent number: 7456968Abstract: A system and method employing optical disk drives for quantitative analysis of chemical and biochemical parameters, in which sensor materials disposed on an optical disk are responsive to physical, chemical, biochemical, and other parameters in the environment. The light interacts with the sensor materials when the light propagates through the sensor material, reflects off the optical media's reflective layer, and propagates back through the sensor region. The interacted light is captured by a photodetector, which outputs a response analog signal, for example, an analog voltage signal, which is indicative of a condition of the environment to which the sensor materials have been exposed. The system includes software algorithms which cause the laser source and optical detector to move to a specified location or logical block address of the disk, measure the optical signal during disk rotation, display a map of the sensor material response, and reduce the noise level in the measured signal.Type: GrantFiled: September 29, 2004Date of Patent: November 25, 2008Assignee: General Electric CompanyInventors: Radislav A. Potyrailo, William G. Morris, Andrew M. Leach
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Publication number: 20080279723Abstract: A quality control system for measuring parameters in a pharmaceutical product includes a receiver vessel to receive a pharmaceutical product therein. The quality control system also includes a sample tube having a first end attached to the receiver vessel to remove pharmaceutical product from the receiver vessel and an appendage connected to a second end of the sample tube. The appendage includes at least one chamber therein to receive a quantity of pharmaceutical product from the receiver vessel. A valve positioned within the sample tube controls flow of the pharmaceutical product to the appendage and prevents flow of the pharmaceutical product from the appendage back into the receiver vessel. The system also includes a quality control device configured to measure at least one parameter of the pharmaceutical product in at least one of the receiver vessel and the appendage.Type: ApplicationFiled: May 11, 2007Publication date: November 13, 2008Inventors: Peter Miller, Andrew M. Leach, Eric Telfeyan, David B. Whitt
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Publication number: 20080240998Abstract: A fluid path system includes a vial containing a frozen pharmaceutical product therein. A dissolution fluid path is also included in the fluid path system, the dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel containing a dissolution medium. A delivery fluid path is also included in the system having a first end hermetically attached to the vial to transport therefrom a mixture of dissolved pharmaceutical product and dissolution medium and a second end connected to a receiving vessel to receive the mixture. A dissolution fluid path valve is positioned between the pressure vessel and the dissolution fluid path to control flow of the dissolution medium, and a delivery fluid path valve is also included in the fluid path system to control flow of the mixture from the delivery fluid path to the receiving vessel.Type: ApplicationFiled: March 28, 2007Publication date: October 2, 2008Inventors: John A. Urbahn, Jan Ardenkjaer-Larsen, Andrew M. Leach, Eric Telfeyan, David K. Dietrich, David B. Whitt, Peter Miller, Ernst W. Stautner
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METHOD AND SYSTEM TO DETECT HUMANS OR ANIMALS WITHIN CONFINED SPACES WITH A LOW RATE OF FALSE ALARMS
Publication number: 20080211668Abstract: The present disclosure describes a detection system and methods for detecting a presence of a person or animal within a confined space with a low false alarm rate. The detection system may include a chemical detector to determine whether respiratory gas concentrations within the confined space exceed a predetermined concentration threshold. The detection system may further include an accelerometer-controlled, range-controlled radar unit to detect movement within the confined space during times in which acceleration of the confined space is less than a predetermined acceleration threshold. In this manner, a measured respiratory gas concentration that initially indicates a presence of a person or animal within the confined space may be confirmed by motion detection.Type: ApplicationFiled: March 2, 2007Publication date: September 4, 2008Inventors: Walter V. Dixon, Andrew M. Leach, Mark Kornfein