Abstract: A hanger assembly includes: a main body; a lock ring coupled to the main body and configured to expand radially outward into a profile on an inner diameter of the wellhead; and an actuator, wherein the actuator is capable of transferring an axial force from the actuator into outward radial expansion of the lock ring toward the profile on the inner diameter of the wellhead. An interface between the actuator and the lock ring is shaped such that: axially downward movement of the actuator from a starting position to an intermediate position actuates the lock ring into the profile; and axially downward movement of the actuator from the intermediate position to a pre-load position applies a pre-load to the hanger assembly.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: This invention relates to a computer implemented method and a computer program product for providing a virtual robotics programming competition. The method comprising the steps of on a server, providing access for a remote client device to a physics library, a physics engine, a rendering engine and an application programming interface (API) mapping the functions of the physics engine to the rendering engine; setting a programming challenge for a user operating the remote client device; receiving a simulation computer program code for a virtual robot from the remote client device; miming the simulation computer program code in a challenge environment; and grading the performance of the simulation computer program code. The performance of the simulation computer program code can be judged based on the results of a live multiplayer robot battle. In this way, students may compete against each other in robotics competitions without the expense and other pitfalls of having to travel to remote locations.

Abstract: An automatic, autonomous, and aircraft-centric interference advisory method is executed entirely on a fist aircraft operating on a movement area of a runway, the movement are including ramps, taxiways, and runways. The method includes a processor onboard the first aircraft computing a first movement projection for the first aircraft using first aircraft data received at the first aircraft; the processor computing additional second movement projections for multiple second aircraft operating on the movement area of the airport using second data regarding each of the multiple second aircraft; the processor detecting a threat to the first aircraft on approach to a defined intersection of the movement area from any of the multiple second aircraft based on a corresponding second movement projection within a configurable time limit of entry into the defined intersection by the first aircraft; and providing on the first aircraft, a threat advisory for a detected threat.

Abstract: This invention relates to a computer implemented method and a computer program product for simulating a 3D object in a browser and sharing that simulation with a plurality of other users on other client devices. There is provided an in-browser simulator comprising: a rendering engine; a physics engine; and an application programming interface (API) mapping the functions of the physics engine to the rendering engine. The API is configured to establish a communication link with the other client devices and to share the simulation data with those devices over the established communication link. In one embodiment, multiple client devices can share their simulations contemporaneously and simulations on one client device can interact with simulations on other devices.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: There is provided a method of controlling a powered air purifying respirator blower system to deliver a substantially uniform volumetric airflow to a user, the system comprising a fan powered by a battery in communication with a variable speed electric motor, the variable speed electric motor is controlled by an electronic control unit for delivering a forced flow of air through at least one filter to a user, comprising the steps of: (a) determining an estimated system run time by summing a battery run time remaining and a system run time; and (b) altering a speed of the variable speed electric motor when the estimated system run time is equal to or less than a desired system run time.

Abstract: The present disclosure relates to molecules capable of binding to both CD20 and PD1, as well as pharmaceutical compositions comprising such molecules and methods of use thereof.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Abstract: This invention relates to a system for teaching computer programming comprising a robot farm, a plurality of remote computing devices and a server. The robot farm comprises a plurality of pods, each housing a robot and having a video camera to capture live video of the robot in the pod. The computing devices are each associated with a robot and transmit control commands to the robot to cause the robot to carry out an action and in return receive live video footage of the robot. The server communicates with the robots, the video cameras and the plurality of remote computing devices to relay control commands from the computing devices to the robots and live video from the video cameras to the computing devices. The computing devices further comprise a user interface having panes, including a programming pane for receipt of control commands, and a video feed pane for displaying video feed of the robot.

Abstract: A method, executed by a processor, includes the processor receiving signals information from a device located on a departing airplane; verifying an identification of the airplane and identifying an expected departure sequence of aircraft surface states; monitoring and identifying additional signals information received from the mobile device, including comparing the additional signals information to known data; logging the additional signals information, and processing the additional signals information, and determining the logged data corresponds to events indicative of an aircraft surface state; sending an aircraft surface state reached message to Local and Center flight management; and executing a statistical routine and providing statistical data from the execution relating to an occurrence of upcoming aircraft surface state event and sending the statistical data with the aircraft surface state message.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: Aspects of a sheath are disclosed herein including a radially expandable outer cylinder and including a plurality of sheath fins distributed circumferentially about the inner surface of the central lumen of the sheath. Each of the fins extends along a length of the inner surface of the sheath and when the sheath not expanded, the form a continuous inner surface of the sheath lumen. Aspects also include a sheath that includes a radially expandable cylindrical outer layer a stiff inner member, an inner liner layer coupled to the inner surface of the stiff inner member; and an outer liner layer disposed between an outer surface of the stiff inner member and an inner surface of the outer layer.

Abstract: A system and a corresponding computer-implemented method identifies and classifies community-sourced documents as true documents. The community-sourced documents include one or more data objects such as data items, including text, strings, phrases, and words; image items, including still image items, video image items, and icons; and drawing items. The system and corresponding method then report the analysis results.

Abstract: There is provided a method of controlling a powered air purifying respirator blower system to deliver a substantially uniform volumetric airflow to a user, the system comprising a fan powered by a battery in communication with a variable speed electric motor, the variable speed electric motor is controlled by an electronic control unit for delivering a forced flow of air through at least one filter to a user, comprising the steps of: (a) determining an estimated system run time by summing a battery run time remaining and a system run time; and (b) altering a speed of the variable speed electric motor when the estimated system run time is equal to or less than a desired system run time.

Abstract: There is provided a method of controlling a powered air purifying respirator blower system to deliver a substantially uniform volumetric airflow to a user, the system comprising a fan powered by a variable speed electric motor, the motor is controlled by an electronic control unit for delivering a forced flow of air through at least one filter to a user, comprising the steps of: (a) monitoring system loading; and (b) decreasing a speed of the electric motor when system loading reaches a predetermined value. There is also provided an air purifying respirator blower system using such a method.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Abstract: Screening methods as well as kits for identifying modulators of hydroxysteroid (17-beta) dehydrogenase (HSD17B) family member proteins, such as HSD17B13, are provided. The methods comprise screening molecules for their capacity to modulate the HSD17B family member protein, including inhibiting the HSD17B family member protein, as measured by substrate depletion, product concentration from the HSD17B family member protein substrate conversion or NADH concentration, levels of labeled substrate, luciferin light emission, or combinations thereof. Inhibitors of HSD17B family member proteins identified through the screening methods may be used to treat liver diseases, disorders, or conditions in which the HSD17B family member protein plays a role.

Abstract: Methods and systems for controlling a powered air purifying respirator blower system where volumetric airflow is stepped down into predetermined discrete ranges based on system loading and desired runtime.