Abstract: A pharmaceutical composition for treatment of a tumor expressing at least one of a plurality of receptor proteins including CD24, Axl, DC-SIGN, Tyro3, MER, MerTK TIM-1, TIM-4, TLR3, TLR8, RIG-1, and MDA5. The pharmaceutical composition includes either a purified viral RNA of an oncolytic Zika virus in a liposome and a pharmaceutically acceptable carrier, or a pharmaceutically acceptable carrier and a unit dosage form of an oncolytic Zika virus.

Abstract: A method for determining the time of maximum fertility in the mammalian ovulation cycle, for the purpose of assisting conception, wherein testing is conducted over a period of days in the current ovulation cycle on samples of body fluid obtained from an individual human subject to detect an elevated concentration of first analyte, such as luteinising hormone (LH) indicative of the event of ovulation, and additionally testing is conducted over a period of days in the current ovulation cycle on samples of body fluid obtained from the individual subject to detect an elevated concentration of a second analyte, such as estradiol or a metabolite thereof, especially estradiol-3-glucuronide (E3G), to provide advance warning of ovulation.

Abstract: A microfluidic device is made up from at least four laminae, the laminae including two outer laminae and at least two further laminae disposed between the outer laminae and defining a microfluidic pathway. Inner surfaces of the outer laminae define the upper and lower surfaces of a fluid pathway, one of said further laminae defining at least a first fluidic element, and at least a second of said further laminae defining at least a second fluidic element, wherein the first and second fluidic elements are fluidically coupled.

Abstract: Disclosed, in one aspect, is an assay result reading device for reading the result of an assay performed using a test strip, the device comprising: a light source or sources, said light source/s emitting light incident upon at least two, spatially separated zones of the test strip; and a photodetector which detects light emanating from each of the two said zones; in a further aspect is disclosed an assay result reading device for reading the result of an assay performed using a test strip, the device comprising: at least one light source incident upon a zone of the test strip; and at least two photodetectors both of which are able to detect some of the light emanating from the zone of the test strip illuminated by the light source.

Abstract: A device for determining the result of an assay may include a computation circuit, responsive to a signal representing the amount of an analyte or the rate of accumulation of an analyte, to: compare the signal to a first threshold; compare the signal to a second threshold, the second threshold being less than the first threshold; generate an output signal if the signal exceeds the first threshold or the signal is less than the second threshold, the output signal indicative of a first result if the signal exceeds the first threshold, or, alternatively, the output signal indicative of a second result if the signal is less than the second threshold; and terminate the assay if the signal exceeds the first threshold or the signal is less than the second threshold.