Patents by Inventor Andrew Powell
Andrew Powell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210347762Abstract: This invention is directed to novel carbocyclic prolinamide derivatives of Formula (I), and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment (e.g., controlling, alleviating, or slowing the progression of) of age-related macular degeneration (AMD) and related diseases of the eye. These diseases include dry-AMD, wet-AMD, geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells. The invention disclosed herein is further directed to methods of prevention, slowing the progress of, and treatment of dry-AMD, wet-AMD, and geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells, comprising: administration of a therapeutically effective amount of compound of the invention.Type: ApplicationFiled: July 14, 2021Publication date: November 11, 2021Applicant: ORION OPHTHALMOLOGY LLCInventors: Robert Gomez, Jinyue Ding, Renata Marcella Oballa, David Andrew Powell
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Patent number: 11091465Abstract: This invention is directed to novel carbocyclic prolinamide derivatives of Formula (I), and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment (e.g., controlling, alleviating, or slowing the progression of) of age-related macular degeneration (AMD) and related diseases of the eye. These diseases include dry-AMD, wet-AMD, geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells. The invention disclosed herein is further directed to methods of prevention, slowing the progress of, and treatment of dry-AMD, wet-AMD, and geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells, comprising: administration of a therapeutically effective amount of compound of the invention.Type: GrantFiled: January 6, 2020Date of Patent: August 17, 2021Assignee: ORION OPHTHALMOLOGY LLCInventors: Robert Gomez, Jinyue Ding, Renata Marcella Oballa, David Andrew Powell
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Patent number: 11004196Abstract: Methods are herein provided for decision support in diagnosis of a disease in a subject, and for extracting features from a multi-slice data set. Systems for computer-aided diagnosis are provided. The systems take as input a plurality of medical data and produces as output a diagnosis based upon this data. The inputs may consist of a combination of image data and clinical data. Diagnosis is performed through feature selection and the use of one or more classifier algorithms.Type: GrantFiled: October 5, 2018Date of Patent: May 11, 2021Assignee: Koninklijke Philips N.V.Inventors: Lilla Boroczky, Lalitha Agnihotri, Luyin Zhao, Michael Chun-chieh Lee, Charles Andrew Powell, Alain C. Borczuk, Steven Kawut
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Patent number: 10968201Abstract: Compounds, compositions and methods are provided for modulating the activity of EP2 and EP4 receptors, and for the treatment, prevention and amelioration of one or more symptoms of diseases or disorders related to the activity of EP2 and EP4 receptors. In certain embodiments, the compounds are antagonists of both the EP2 and EP4 receptors.Type: GrantFiled: April 17, 2019Date of Patent: April 6, 2021Assignee: TEMPEST THERAPEUTICS, INC.Inventors: Yalda Bravo, Austin Chih-Yu Chen, Jinyue Ding, Robert Gomez, Heather Lam, Joe Fred Nagamizo, Renata Marcella Oballa, David Andrew Powell, Tao Sheng
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Publication number: 20210024491Abstract: Compounds, compositions and methods are provided for modulating the activity of EP2 and EP4 receptors, and for the treatment, prevention and amelioration of one or more symptoms of diseases or disorders related to the activity of EP2 and EP4 receptors. In certain embodiments, the compounds are antagonists of both the EP2 and EP4 receptors.Type: ApplicationFiled: October 14, 2020Publication date: January 28, 2021Inventors: Yalda BRAVO, Austin Chih-Yu CHEN, Jinyue DING, Robert GOMEZ, Heather LAM, Joe Fred NAGAMIZO, Renata Marcella OBALLA, David Andrew POWELL, Tao SHENG
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Patent number: 10900262Abstract: A handle assembly for engaging and disengaging a locking or securing device. The assembly comprises an actuator, and a rotatable exterior handle. In use, the exterior handle rotates the actuator to engage or disengage the locking or securing device. The exterior handle is structured to only rotate and engage the actuator when the exterior handle is removed from its retracted position into its extended position.Type: GrantFiled: August 2, 2017Date of Patent: January 26, 2021Assignee: Aviation Technical Services, inc.Inventors: Andrew Powell, Larry Coburn, Antonio Zuniga, Asia Davis
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Publication number: 20200385362Abstract: This invention is directed to novel carbocyclic prolinamide derivatives of Formula (I), and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment (e.g., controlling, alleviating, or slowing the progression of) of age-related macular degeneration (AMD) and related diseases of the eye. These diseases include dry-AMD, wet-AMD, geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells. The invention disclosed herein is further directed to methods of prevention, slowing the progress of, and treatment of dry-AMD, wet-AMD, and geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells, comprising: administration of a therapeutically effective amount of compound of the invention.Type: ApplicationFiled: January 6, 2020Publication date: December 10, 2020Applicant: ORION OPHTHALMOLOGY LLCInventors: Robert Gomez, Jinyue Ding, Renata Marcella Oballa, David Andrew Powell
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Patent number: 10730832Abstract: This invention is directed to novel aliphatic prolinamide derivatives of Formula I, and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment (e.g., controlling, alleviating, or slowing the progression of) of age-related macular degeneration (AMD) and related diseases of the eye. These diseases include dry-AMD, wet-AMD, geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells. The invention disclosed herein is further directed to methods of prevention, slowing the progress of, and treatment of dry-AMD, wet-AMD, and geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells, comprising: administration of a therapeutically effective amount of compound of the invention.Type: GrantFiled: June 15, 2017Date of Patent: August 4, 2020Assignee: ORION OPHTHALMOLOGY LLCInventors: Austin Chih-Yu Chen, Robert Gomez, Renata Marcella Oballa, David Andrew Powell, Jeffrey Roger Roppe, Thomas Jon Seiders, Tao Sheng
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Publication number: 20200090209Abstract: A system for providing virtual coupons to a customer illustratively includes a database having a plurality of virtual coupons stored therein, a virtual coupon repository associated with the customer, and a virtual coupon module to transfer selected ones of the plurality of virtual coupons stored in the database to the virtual coupon repository, and to sequentially activate for redemption by the customer each successive virtual coupon in the sequence after a preceding virtual coupon in the sequence has been redeemed by the customer. At least one of the selected virtual coupons selected based on one or more items in a purchase history stored in the database and associated in the database with the customer.Type: ApplicationFiled: November 22, 2019Publication date: March 19, 2020Inventors: Bhushan Balani, Andrew Powell, Shrineil Patel
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Patent number: 10562579Abstract: A seal for a meter housing with an interior portion is disclosed. The seal includes an axially inner surface configured to face the interior portion of the meter housing and an axially outer surface configured to face away from the interior portion of the meter housing. At least one of the axially inner surface and the axially outer surface is configured to seal against a portion of the housing. The seal further includes a diaphragm defined axially intermediate the axially inner surface and the axially outer surface and a fluid passageway defined through a portion of the diaphragm. The fluid passageway is configured to move between an open position and a closed position in response to a pressure differential between the interior portion of the housing and an exterior portion.Type: GrantFiled: March 28, 2017Date of Patent: February 18, 2020Assignee: Polaris Industries Inc.Inventors: Geoffrey Wotton, Mark Andrew Powell, Benjamin Travis Chambers, Justin Larson
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Patent number: 10526315Abstract: This invention is directed to novel carbocyclic prolinamide derivatives of Formula (I), and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment (e.g., controlling, alleviating, or slowing the progression of) of age-related macular degeneration (AMD) and related diseases of the eye. These diseases include dry-AMD, wet-AMD, geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells. The invention disclosed herein is further directed to methods of prevention, slowing the progress of, and treatment of dry-AMD, wet-AMD, and geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells, comprising: administration of a therapeutically effective amount of compound of the invention.Type: GrantFiled: June 15, 2017Date of Patent: January 7, 2020Assignee: ORION OPHTHALMOLOGY LLCInventors: Robert Gomez, Jinyue Ding, Renata Marcella Oballa, David Andrew Powell
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Publication number: 20190390794Abstract: The disclosure relates to a clamping device and method of securing a clamping device. The clamping device is suitable for clamping an elongate member, and includes a body portion for surrounding the elongate element and configured to apply a compressive force on the elongate member. The body portion includes at least two outwardly curved plates.Type: ApplicationFiled: November 27, 2017Publication date: December 26, 2019Applicant: GE Oil & Gas UK LimitedInventors: David Legg, Andrew Powell, Richard David Carverhill
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Publication number: 20190330146Abstract: This invention is directed to novel aliphatic prolinamide derivatives of Formula I, and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment (e.g., controlling, alleviating, or slowing the progression of) of age-related macular degeneration (AMD) and related diseases of the eye. These diseases include dry-AMD, wet-AMD, geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells. The invention disclosed herein is further directed to methods of prevention, slowing the progress of, and treatment of dry-AMD, wet-AMD, and geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells, comprising: administration of a therapeutically effective amount of compound of the invention.Type: ApplicationFiled: June 15, 2017Publication date: October 31, 2019Applicant: ORION OPHTHALMOLOGY LLCInventors: Austin Chih-Yu Chen, Robert Gomez, Renata Marcella Oballa, David Andrew Powell, Jeffrey Roger Roppe, Thomas Jon Seiders, Tao Sheng
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Publication number: 20190322645Abstract: This invention is directed to novel heterocyclic prolinamide derivatives of Formula (I), and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment (e.g., (s) controlling, alleviating, or slowing the progression of) of age-related macular degeneration (AMD) and related diseases of the eye. These diseases include dry-AMD, wet-AMD, geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells. The invention disclosed herein is further directed to methods of prevention, slowing the progress of, and treatment of dry-AMD, wet-AMD, and geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells, comprising: administration of a therapeutically effective amount of compound of the invention.Type: ApplicationFiled: June 15, 2017Publication date: October 24, 2019Applicant: ORION OPHTHALMOLOGY LLCInventors: Robert Gomez, Jinyue Ding, Renata Marcella Oballa, David Andrew Powell, Maxim Epifanov
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Publication number: 20190315712Abstract: Compounds, compositions and methods are provided for modulating the activity of EP2 and EP4 receptors, and for the treatment, prevention and amelioration of one or more symptoms of diseases or disorders related to the activity of EP2 and EP4 receptors. In certain embodiments, the compounds are antagonists of both the EP2 and EP4 receptors.Type: ApplicationFiled: April 17, 2019Publication date: October 17, 2019Inventors: Yalda BRAVO, Austin Chih-Yu CHEN, Jinyue DING, Robert GOMEZ, Heather LAM, Joe Fred NAGAMIZO, Renata Marcella OBALLA, David Andrew POWELL, Tao SHENG
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Publication number: 20190202810Abstract: This invention is directed to novel carbocyclic prolinamide derivatives of Formula (I), and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk of developing) and treatment (e.g., controlling, alleviating, or slowing the progression of) of age-related macular degeneration (AMD) and related diseases of the eye. These diseases include dry-AMD, wet-AMD, geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells. The invention disclosed herein is further directed to methods of prevention, slowing the progress of, and treatment of dry-AMD, wet-AMD, and geographic atrophy, diabetic retinopathy, retinopathy of prematurity, polypoidal choroidal vasculopathy, and degeneration of retinal or photoreceptor cells, comprising: administration of a therapeutically effective amount of compound of the invention.Type: ApplicationFiled: June 15, 2017Publication date: July 4, 2019Applicant: Orion Ophthalmology LLCInventors: Robert GOMEZ, Jinyue DING, Renata Marcella OBALLA, David Andrew POWELL
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Publication number: 20190108632Abstract: Methods are herein provided for decision support in diagnosis of a disease in a subject, and for extracting features from a multi-slice data set. Systems for computer-aided diagnosis are provided. The systems take as input a plurality of medical data and produces as output a diagnosis based upon this data. The inputs may consist of a combination of image data and clinical data. Diagnosis is performed through feature selection and the use of one or more classifier algorithms.Type: ApplicationFiled: October 5, 2018Publication date: April 11, 2019Inventors: Lilla Boroczky, Lalitha Agnihotri, Luyin Zhao, Michael Chun-chieh Lee, Charles Andrew Powell, Alain C. Borczuk, Steven Kawut
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Publication number: 20190011273Abstract: A system includes a route-optimization module configured to calculate an efficient route. The module is also configured to utilize modelled vehicle-efficiency data, reflecting expected performance, for determining route efficiency and project driver-specific efficiency along a proposed route. The module is further configured to utilize efficiency-affecting vehicle state data to determine projected state efficiency-impact. The system also includes a guidance module configured to provide real-time guidance targets including gear selection and vehicle speed and provide real-time feedback to the driver comparing observed vehicle performance to the guidance targets.Type: ApplicationFiled: July 10, 2018Publication date: January 10, 2019Applicant: FORD GLOBAL TECHNOLOGIES, LLCInventors: Richard Andrew POWELL, Owen Fraser WOOD, Jonathan SCOTT
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Patent number: 10121243Abstract: Methods are herein provided for decision support in diagnosis of a disease in a subject, and for extracting features from a multi-slice data set. Systems for computer-aided diagnosis are provided. The systems take as input a plurality of medical data and produces as output a diagnosis based upon this data. The inputs may consist of a combination of image data and clinical data. Diagnosis is performed through feature selection and the use of one or more classifier algorithms.Type: GrantFiled: September 18, 2007Date of Patent: November 6, 2018Assignee: Koninklijke Philips N.V.Inventors: Lilla Boroczky, Lalitha Agnihotri, Luyin Zhao, Michael Chun-Chieh Lee, Charles Andrew Powell, Alain C. Borczuk, Steven Kawut
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Patent number: 9977584Abstract: A computing device can periodically acquire a current track time for a media content item being played. The device can periodically compare the current track time with a respective start time and a respective end time for each line (or segment) in a plurality of lines of text (or segments of text) associated with the media content item. If the device determines that the current track time is between start and end times for a given line of text, then the device can display the given line of text. A user of the device can scroll through the lines of text associated with the media content item. If the user selects a particular line of text, the device can identify a start time for the selected line of text. The device can then play the media content item at the identified start time of the selected line of text.Type: GrantFiled: September 21, 2015Date of Patent: May 22, 2018Assignee: AMAZON TECHNOLOGIES, INC.Inventors: Toby Ray Latin-Stoermer, Jonathan Beech, Hari Gangadharan, Gabriela Ahern, Brandon Scott Durham, Darren Levi Malek, Ralph Cameron Harvey, Benjamin Lee Shepherd, Jason Christopher Hall, Andrew Powell McGoogan, Robert Richard Morse