Abstract: The present disclosure relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods using such ADCs, and methods for making such ADCs.

Abstract: In an embodiment, an animator is provided with an indication when a model's component such as a joint or limb is being moved or twisted in a way that would be unnatural and cause unusual stress on the model component. For example, as a shoulder joint is stressed by moving an arm in an extreme position a yellow bar or coloring of the shoulder, arm or other component can grow increasingly bright and shift to red just before a breaking point is reached. An animator can choose to go past the breaking point and the breaking can be modeled and incorporated into the animation.

Abstract: An aspect provides a computer-implemented method for operating animation controls associated with an animation control rig. The method comprises determining a node graph used to operate one or more animation controls; receiving an executable code object configured to replace at least two nodes disposed in the node graph at runtime, wherein the executable code object is configured to execute animation control inputs used to control the one or more animation controls at runtime as a single execution block configured to merge at least two data evaluation processes into a single data evaluation process to reduce execution overhead; processing the control data inputs using the executable code object; and operating the one or more animation controls with respect to the single execution instruction in response to the control data inputs.

Abstract: An aspect provides a computer-implemented method for generating an animation control rig configured to manipulate a skeleton of an animated character. The method comprises associating 502 a plurality of animation control points to an animated skeleton; traversing (504, 512) a node graph representing the plurality of animation control points of the animated skeleton; analyzing 506 the hierarchical node graph to determine which nodes of the hierarchical node graph are inversely solvable; analyzing 508 the hierarchical node graph to determine which other nodes of the hierarchical node graph are solvable with at least one solution that violates a constraint of the animated skeleton; and modifying 510 an operation of at least one node of the other nodes that violates a constraint to approximate the constraint within a tolerance level.

Abstract: In an embodiment, an animator is provided with an indication when a model's component such as a joint or limb is being moved or twisted in a way that would be unnatural and cause unusual stress on the model component. For example, as a shoulder joint is stressed by moving an arm in an extreme position a yellow bar or coloring of the shoulder, arm or other component can grow increasingly bright and shift to red just before a breaking point is reached. An animator can choose to go past the breaking point and the breaking can be modeled and incorporated into the animation.

Abstract: An air cooler system for use in association with an air circulation system and having a process air heat exchanger for recovering heat from the process air in the system, a vacuum chamber with a vacuum chamber heat exchanger in communication with the process air heat exchanger so as to transfer heat from process air heat exchanger to the vacuum chamber heat exchanger, a water supply for supplying water to the vacuum chamber and, vacuum source to draw a predetermined degree of vacuum in the vacuum chamber so as to reduce the boiling point of water therein.