Abstract: Systems, apparatuses, and methods disclosed herein may be directed to clips for medical implementation, including clips for a portion of a heart. The clips may be configured to close the portion of the heart, to reduce blood flow therethrough as well as passage of clots or other undesired materials. In examples, the clips may be configured to close the left atrial appendage (LAA). The closure of the LAA may reduce the possibility of stroke or other maladies stemming from fluid flow with the LAA. In examples, the clips may be positioned exterior of the LAA, to extend over an outer surface of the LAA for closure.

Abstract: A method is disclosed of changing a tool on a programmable motion device. The method includes the steps of moving an attachment portion of an end effector of the programmable motion device in a continuous motion; while the attachment portion of the end effector moves in the continuous motion, engaging one of: the attachment portion of the end effector with the tool, or the tool attached to the attachment portion of the end effector with an exchange system, and continuing to move the attachment portion of the end effector in the continuous motion to change a connection status of the attachment portion of the end effector while the attachment portion of the end effector moves in the continuous motion.

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

Abstract: An exemplary embodiment of the present disclosure provides a system comprising a pipette tip manipulable between a sample area and an active agent exposure zone and a controller configured to manipulate the pipette tip between the sample area and the active agent exposure zone, wherein when the pipette tip comprises at least a portion of a biological sample target, the controller is further configured to isolate at least a portion of the biological sample target from one or more biological sample targets. Also disclosed is a method for detecting an effect of an active agent on a cell, by forming a high-resistance seal between a cell and an apertured surface, isolating at least a portion of the cell, translocating the apertured surface in one or more translations within an x-plane, a y-plane, a z-plane, or combinations thereof, and exposing the portion of the cell to an active agent.

Abstract: Provided herein are methods for making a crystalline form of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4?-(morpholinomethyl)-[1,1?-biphenyl]-3-carboxamide hydrobromide and related products, compositions and treatment methods.

Abstract: There is disclosed herein metal nitrate hydrates as phase change materials (PCMs). More particularly, there is disclosed herein metal nitrate hydrate PCMs containing group II metal nitrates as nucleation agents. A further disclosure herein is the combination of multiple chemical species in the PCM formulation which act together to induce nucleation of metal nitrate PCMs. Furthermore, physical mechanisms by which nucleation of metal nitrate hydrate based PCMs and crystallisation rate increased are disclosed.

Abstract: Embodiments improve software defect diagnosis. Analytic focus is automatically walked back from an initial symptomatic diagnostic context to a previous diagnostic context that is closer to underlying causes. Diagnosis may obtain diagnostic artifacts such as traces or dumps, extract diagnostic context, decompile executables, lookup likely causes based on symptoms, scan logs, and submit diagnostic context to software analysis services. An analysis service may perform static analysis, security testing, symptom-pair lookups, or antipattern scanning, for example, and may include a neural network or other machine learning model, for example. Root causes are culled from analysis results and identified to a software developer. Changes to mitigate the defect's impact are suggested in some cases. Thus, the software developer receives debugging leads without manually navigating through all the tool interfaces or unrelated details of diagnostic contexts.

Abstract: A gas turbine engine comprises a fan, a core turbine engine coupled to the fan, a fan case housing the fan and the core turbine engine, a plurality of outlet guide vanes extending between the core turbine engine and the fan case, and an acoustic spacing. The fan comprises a plurality of fan blades that define a fan diameter and a BEAL. The fan case comprises an inlet and an inlet length between the inlet and the fan. The acoustic spacing comprises a distance between the fan and the plurality of outlet guide vanes, and in combination with the BEAL determines an acoustic spacing ratio of the gas turbine engine.

Abstract: An Isolating Transmission Line Transformer (ITLT) for use in a data communications system is provided, the transformer comprising: a substantially planar substrate formed of electrically insulative material having opposed first and second surfaces; a first port formed of two separate terminals provided at one part of the substrate; a second port formed of two separate terminals provided at a second part of the substrate; a first conductor connected in series to the first port and arranged as a single loop; a second conductor which is electrically isolated from the first conductor and connected in series to the second port, the second conductor being arranged as a single loop in a substantially opposite orientation to the first conductor; wherein the first and second ports and at least part of the first and second conductors are provided on the substrate surface(s); and a core arranged between the first and second ports to cover the majority of the first and second conductors.

Abstract: The invention relates to a breathing assistance apparatus that may be configured to reduce the risk of damage to electronics within the apparatus as a result of liquid leaks within the apparatus or impacts to the apparatus. In other forms, the apparatus may be configured to allow for easy assembly and/or safe operation.

Abstract: A wearable display system includes one or more emissive micro-displays, e.g., micro-LED displays. The micro-displays may be monochrome micro-displays or full-color micro-displays. The micro-displays may include arrays of light emitters. Light collimators may be utilized to narrow the angular emission profile of light emitted by the light emitters. Where a plurality of emissive micro-displays is utilized, the micro-displays may be positioned at different sides of an optical combiner, e.g., an X-cube prism which receives light rays from different micro-displays and outputs the light rays from the same face of the cube. The optical combiner directs the light to projection optics, which outputs the light to an eyepiece that relays the light to a user's eye. The eyepiece may output the light to the user's eye with different amounts of wavefront divergence, to place virtual content on different depth planes.

Abstract: Templated document stream integration of checklist data includes loading different checklist templates for a generic endpoint in a computing infrastructure, each containing partially filed data and each corresponding to a different security policy hardening the generic endpoint from a cyberthreat. Specific endpoints are then selected in the computing infrastructure and, for each corresponding specific endpoint, a set of checklists generated, each checklist in the set deriving from a different checklist template and including the partially filled data of one of the different checklist templates. Further, remediation data stored in a data store of an enterprise application is merged into each one of the generated checklists in the set. Finally, the enterprise application is updated with respect to the corresponding one of the selected specific endpoints with the different checklists merging the partially filled data and the remediation data.

Abstract: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.

Abstract: A bottom bracket assembly with interconnected axle and crank arms. Each end of the axle has a plurality of angled surfaces and a recess formed with a depth through at least the axle perimeter and at least partially around the perimeter of the axle. Each crank arm has a slot formed a distance along the length such that the end of the crank arm is separated into two deflectable jaws. A bore is formed orthogonal to the slot and a fastener is installed in the bore, wherein the fastener has a length to span the slot in the crank arm to engage both deflectable jaws. The fastener has a shank radius that extends to a depth of the recess. Removal of the crank arm from the axle end is opposed when the fastener is in the bore.

Abstract: A golf club head is provided with an electronic display that is visible to a user of the golf club head when the golf club head is in the address position, such as for displaying one or more images to the user. The electronic display may include a memory, a microprocessor, and a battery, and may be configured to communicate with a user operable electronic device via a wired or a wireless communication protocol. For example, the electronic display may be configured to receive one or more images from the user operable electronic device, to store the one or more images in the memory, and to display the one or more images to the user.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing neural architecture search for machine learning models. In one aspect, a method comprises receiving training data for a machine learning, generating a plurality of candidate neural networks for performing the machine learning task, wherein each candidate neural network comprises a plurality of instances of a layer block composed of a plurality of layers, for each candidate neural network, selecting a respective type for each of the plurality of layers from a set of layer types that comprises, training the candidate neural network and evaluating performance scores for the trained candidate neural networks as applied to the machine learning task, and determining a final neural network for performing the machine learning task based at least on the performance scores for the candidate neural networks.

Abstract: Techniques are disclosed for systems and methods associated with a micromobility transit vehicle battery connection and lock. In accordance with one or more embodiments, a micromobility transit vehicle is provided. The micromobility transit vehicle may include a frame, a battery configured to be received at least partially within the frame, and a battery lock within the frame. The frame may include a downtube having a recess disposed therein. The battery may be configured to be received within the downtube and the recess to establish a continuous surface comprising one or more outer surfaces of the downtube and one or more outer surfaces of the battery. The battery lock may be positioned within the recess and configured to engage the battery to lock the battery in place.

Abstract: Computer-implemented methods and structures deploy a heating ventilation and air conditioning (HVAC) energy optimization program. A standard operating control platform (OCP) is deployed in an energy optimization control engine (EOCE) computing system communicatively coupled to a plurality of HVAC components via a building automation system (BAS). An energy optimization portal (EOP), which receives from the EOCE computing system a first data set identifying the plurality of HVAC components, a second data set including operational control parameters for each of the plurality of HVAC components, and a third data set including measured operations data associated with each of the plurality of HVAC components. The EOP generates an energy optimized operating control platform based on the first, second, and third data sets, which is automatically communicated from the EOP to the EOCE computing system.

Abstract: A vacuum cleaner including a vacuum motor configured to draw an air flow through an air flow path of the vacuum cleaner; a dirt separator having dirt, receptacle; a display screen; and a controller configured to control images displayed on the screen. The dirt receptacle has a closed configuration in which it can receive dirt separated from the air flow, and an open configuration in which dirt contained in the dirt receptacle can be emptied therefrom. The controller is configured to display video instructions on the screen.

Abstract: A disclosed apparatus obtains emergency data for multiple device types from a plurality of emergency data sources and provides a jurisdictional map view to a plurality of emergency network entities, where each emergency network entity corresponds to a given geographic boundary. The jurisdictional map view corresponds to a respective emergency network entity's geographic boundary. The apparatus determines portions of the emergency data corresponding to emergencies occurring within each respective emergency network entity geographic boundary, and provides location indicators within each respective jurisdictional map view, with each location indicator corresponding to an emergency.