Abstract: A tension-inducing shaft system includes a shaft, two shaft caps, and a biasing mechanism. A bore extends through the shaft between two ends of the shaft. The shaft caps are positioned on the two ends of the shaft. Each shaft cap includes a collar having a size that is larger than the bore, a keyed end, and an anchor. The biasing mechanism is arranged inside the bore and is coupled to the anchors of the shaft caps so that the biasing mechanism exerts inward forces on the shaft cap. The keyed ends of the shaft caps can be coupled to a housing so that the shaft caps do not rotate with respect to the housing. The shaft is configured to rotate with respect to the shaft caps such that, when the keyed ends are coupled to the housing, the shaft is capable of rotating with respect to the housing.

Abstract: A mandrel includes a shaft that can hold a supply roll of film. A primary button and one or more secondary buttons are located on the shaft. The primary button and the one or more secondary buttons are biased toward an extended position and are capable of moving to a retracted position. The primary button and the one or more secondary buttons retract to the retracted position during at least a portion of loading the supply roll of film onto the shaft. The retraction of the primary button to the retracted position causes retraction of the one or more secondary buttons to the retracted position. When the supply roll of film is in an aligned position on the shaft, the supply roll of film is maintained in the aligned position in part by one of the primary button and the one or more secondary buttons in the extended position.

Abstract: An example shuttle valve includes: (i) a valve body comprising a longitudinal cylindrical bore, a first inlet port, a second inlet port, an outlet port, and a key that protrudes radially inward within the longitudinal cylindrical bore; and (ii) a shuttle mounted in the longitudinal cylindrical bore and configured to move axially therein, wherein the shuttle comprises a plurality of radial protrusions that protrude radially outward from, and are circumferentially spaced apart about, a peripheral surface of the shuttle, and wherein the key of the valve body is interposed between two radial protrusions of the plurality of radial protrusions.

Abstract: A mandrel includes a shaft that can hold a supply roll of film. A primary button and one or more secondary buttons are located on the shaft. The primary button and the one or more secondary buttons are biased toward an extended position and are capable of moving to a retracted position. The primary button and the one or more secondary buttons retract to the retracted position during at least a portion of loading the supply roll of film onto the shaft. The retraction of the primary button to the retracted position causes retraction of the one or more secondary buttons to the retracted position. When the supply roll of film is in an aligned position on the shaft, the supply roll of film is maintained in the aligned position in part by one of the primary button and the one or more secondary buttons in the extended position.

Abstract: An example shuttle valve includes: (i) a valve body comprising a longitudinal cylindrical bore, a first inlet port, a second inlet port, an outlet port, and a key that protrudes radially inward within the longitudinal cylindrical bore; and (ii) a shuttle mounted in the longitudinal cylindrical bore and configured to move axially therein, wherein the shuttle comprises a plurality of radial protrusions that protrude radially outward from, and are circumferentially spaced apart about, a peripheral surface of the shuttle, and wherein the key of the valve body is interposed between two radial protrusions of the plurality of radial protrusions.

Abstract: The present invention relates, at least in part, to polypeptides which include Bcl-xL binding domains, novel Bcl-xL binding domains of Pablo polypeptides, nucleic acid molecules encoding such polypeptides, and uses thereof. For example, such polypeptides and nucleic acid molecules are useful in modulating apoptosis, particularly in neural cells, as well as in the treatment or prevention of disorders that can benefit from modulation of cell death.

Abstract: The present invention relates, at least in part, to polypeptides which include Bcl-xL binding domains, novel Bcl-xL binding domains of Pablo polypeptides, nucleic acid molecules encoding such polypeptides, and uses thereof. For example, such polypeptides and nucleic acid molecules are useful in modulating apoptosis, particularly in neural cells, as well as in the treatment or prevention of disorders that can benefit from modulation of cell death.

Abstract: A MORT1 gene initially cloned from HeLa cells and identified as a member of the receptor mediated apoptotic pathway, is expressed in the human neuronal cell line, NTERA2. Isolation of the MORT1 from this cell line revealed a transcript isoform that differed from the known MORT1 sequence by a deletion of 21 base pairs (bp 172-192 of the coding sequence). Cloning of MORT1 from adult human brain revealed two isoforms, one similarly deleted for bp 172-192, the other with a basepair substitution, A for G at position 173. Assessment of MORT1 function in a yeast two hybrid system indicates that the deleted and intact forms of MORT1 differ in their capacity to interact with other members of the apoptotic pathway.