Abstract: A system and method for generating simulated full limb animations in real time based on sensor and tracking data. A computing environment for receiving and processing tracking data from one or more sensors, for mapping tracking data onto a 3D model having a skeletal hierarchy and a surface topology, and for rendering an avatar for display in virtual reality. A method for animating a full-bodied avatar from tracking data collected from an amputee. A means for determining, predicting, or modulating movements an amputee intends to make with his or her simulated full limb. A modified inverse kinematics method for arbitrarily and artificially overriding a position and orientation of a tracked end effector. Synchronous virtual reality therapeutic activities with predefined movement patterns that may modulate animations.

Abstract: A messaging system, comprising an electronic message having integrated digital content that is scripted by seamless linking of multiplicity of electronic media components. An electronic media component is comprised of a compilation of one or more electronic media element, with an electronic media element comprised of one or more data. Communication protocols for delivery and receipt of the electronic message is used, with the multiplicity of electronic media components of a received electronic message seamlessly executed in an order, arrangement, and sequence intended by the scripted digital content at one of a first and second client-device.

Abstract: A messaging system, comprising an electronic message having integrated digital content that is scripted by seamless linking of multiplicity of electronic media components. An electronic media component is comprised of a compilation of one or more electronic media element, with an electronic media element comprised of one or more data. Communication protocols for delivery and receipt of the electronic message is used, with the multiplicity of electronic media components of a received electronic message seamlessly executed in an order, arrangement, and sequence intended by the scripted digital content at one of a first and second client-device.

Abstract: The invention is directed to compounds of formula (I), and salts thereof. The compounds are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention provides a fire-stopping product, an insulated building façade comprising a fire-stopping product, and a method of making a fire-stopping product. The fire-stopping product comprises a resilient, porous material at least partially impregnated with an intumescent agent and held in compression by a releasable restraint. When exposed to hot gases from a fire, the restraint yields to release the resilient, porous material in an initial expansion, thereby exposing the intumescent agent to the hot gases and allowing rapid intumescence to occur. When implemented in a ventilated building façade, the fire-stopping product is able to close an air gap in a short amount of time.

Abstract: An ice protection system adapted to protect at least one ice-susceptible flight surface of an aircraft includes a mechanical ice protection device attached to the flight surface. A controller controls a power source that causes the mechanical ice protection device to change in shape and, thereby, change an aerodynamic characteristic of the flight surface. This change in shape happens only when the current thickness of ice on the surface exceeds a minimum thickness.

Abstract: A request is received from a client device over a Virtual Private Network (VPN) tunnel. The request is received at a first one of a plurality of edge servers of a distributed cloud computing network. A destination of the request is determined and an optimized route for transmitting the request toward an origin server is determined. The optimized route is based at least in part on probe data between edge servers of the distributed cloud computing network. The request is transmitted to a next hop as defined by the optimized route.

Abstract: Methods of culturing and detecting a biomarker which may be associated with autoimmune diseases, in particular inflammatory bowel disease and Crohn's disease; also a screening method for substances suitable for the treatment of inflammatory bowel disease including Crohn's disease; the method including culturing a biomarker in a culture media which includes a culture broth, OADC, PANTA and Mycobactin J.

Abstract: The invention is directed to compounds of formula (I), and salts thereof. The compounds are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments, the metal tricarbonyl complexes are used as radioisotope tracers such as renal tracers. In certain embodiments, the metal complexes comprise 99mTc or Re. In certain embodiments, the ligands are substituted with a fluorine, a fluorine-18(F18) radioisotope, or other radionuclide.

Abstract: A wound treatment simulation device and method of operating thereof are disclosed. The device includes a housing, a simulated wound structure, a pump, a power supply, a sensor, a feedback device, and a microprocessor. The housing is configured to be secured to the live subject and to cover at least a portion of a body of the subject. The wound structure is configured to simulate a structure associated with the type of simulated wound treatment. The at least one feedback device is configured to provide a feedback signal to the live subject. The microprocessor is connected to the sensor and the feedback device. The microprocessor is programmed to operate the feedback device to provide haptic feedback based upon input (e.g. force or pressure) generated from interaction between a treatment provider and the simulated wound structure. The disclosed device may be used to simulate a variety of wound care and treatments.

Abstract: A fuel system is provided that includes a fuel system frame and in some cases access steps. The frame can be mounted to a vehicle frame rail. Bracket assemblies can be coupled to the fuel system frame at a plurality of positions. The fuel tank can be mounted at neck portions thereof and can be supported on the frame rail between the neck portion, e.g., spaced a distance from the neck portions in a longitudinal direction of the fuel system. The access steps can be non-rectangular to provide a wide stepping portion even if the fuel system includes large tanks. The steps can be directly supported by an outside surface of the tank.

Abstract: A heater mat for heating an airfoil having a chord, a leading edge, and a trailing edge includes a first zone element configured to heat a first chord-wise segment of the airfoil. The system further includes a second zone element configured to heat a second chord-wise segment of the airfoil that is adjacent to the first chord-wise segment of the airfoil. The system further includes a first zone busbar located at the leading edge of the heater mat and electrically coupled to the first zone element.

Abstract: A request is received from a client device over a Virtual Private Network (VPN) tunnel. The request is received at a first one of a plurality of edge servers of a distributed cloud computing network. A destination of the request is determined and an optimized route for transmitting the request toward an origin server is determined. The optimized route is based at least in part on probe data between edge servers of the distributed cloud computing network. The request is transmitted to a next hop as defined by the optimized route.

Abstract: A fuel system is provided that includes a mounting block assembly configured to support an end of a fuel tank. The end of the fuel tank has a boss. The mounting block assembly encloses a space configured to receive the boss of the fuel tank. The fuel system also includes a bearing disposed in the space. The bearing has a support surface configured for sliding support of the boss of the fuel tank at an interface between the first portion and the second portion of the mounting block assembly. The mounting block assembly has a debris mitigation structure, such as one or more of a wiper disposed in the bearing adjacent to the support surface, an endcap configured to be mounted around the boss, and a cover configured to at least partially enclose a span of a boss between an enclosed space of the fuel tank and an inboard side of the mounting block assembly.

Abstract: Disclosed is a shoulder brace for immobilization of the arm and shoulder joint in neutral abduction/adduction. Methods of using the brace and methods of treating shoulder injuries are similarly provided.

Abstract: The invention provides a process for the preparation of 1234yf comprising (a) contacting 1,1,2,3,3,3-hexafluoropropene (1216) with hydrogen in the presence of a hydrogenation catalyst to produce 1,1,2,3,3,3-hexafluoropropane (236ea); (b) dehydrofluorinating 236ea to produce 1,2,3,3,3-pentafluoropropene (1225ye); (c) contacting 1225ye with hydrogen in the presence of a hydrogenation catalyst to produce 1,2,3,3,3-pentafluoropropane (245eb); and (d) dehydrofluorinating 245eb to produce 1234yf.

Abstract: This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments, the metal tricarbonyl complexes are used as radioisotope tracers such as renal tracers. In certain embodiments, the metal complexes comprise 99mTc or Re. In certain embodiments, the ligands are substituted with a fluorine, a fluorine-18(F18) radioisotope, or other radionuclide.

Abstract: A system includes a mandrel contoured to define a tapering tubular shape of a workpiece cured on the mandrel and a demolding tool. The demolding tool is configured to remove the workpiece from the mandrel after the workpiece is cured on the mandrel and cut longitudinally. The demolding tool is configured to remove the workpiece from the mandrel by deforming a first end of the workpiece to at least partially disengage the first end of the workpiece from a first end of the mandrel, and subsequently, deforming a second end of the workpiece to at least partially disengage the second end of the workpiece from a second end of the mandrel. The first end of the workpiece may have a first cross-sectional area that is smaller than a second cross-sectional area of the second end of the workpiece.

Abstract: A system for powering a vehicle is provided. The system can include an engine or power generation system to be powered by a fuel and a housing. The housing can be configured to couple to one or more frame rails of the vehicle, receive and protect a cylinder configured to store the fuel to be used by the engine or power generation system. The housing can have one or more access panels allowing access to an interior of the housing. The cylinder can include a first end portion, a second end portion, a central body forming an enclosed cavity for storing pressurized gas, a reinforcement structure disposed over the central body, and a metal foil interposed between the reinforcement structure and central body. The metal foil can be configured to reduce permeation of contents of the cylinder.