Abstract: There is disclosed a system for monitoring, non-invasively, intracranial pressure of a subject. The system includes a vibroacoustic sensor and an electric potential sensor. The vibroacoustic sensor is configured to detect vibroacoustic signals associated with intracranial pressure of the subject, within a bandwidth ranging from about 0.01 Hz to about 20 kHz. The electric potential sensor is configured to detect electric potential signals reflective of baseline time-based events in the subject for identifying baseline time-based intracranial pressure changes from the detected vibroacoustic signals. The vibroacoustic sensor is housed in a wearable device. The wearable device is configured to be non-invasively coupled to the subject's head.

Abstract: In various embodiments, a drug pump includes a housing and, within the housing, an expandable drug reservoir at least part of which is exposed to a pressurized propellant. The propellant exerts a substantially constant pressure on the drug reservoir. A flow restrictor significantly limits outflow from the pump, and preferably has both a small diameter and a long path length, which acts to control the outflow from the drug reservoir. As a result, the pump produces a substantially constant outflow.

Abstract: An ophthalmic liquid delivery apparatus includes a bulbar conjunctiva contacting surface, a palpebral conjunctiva contacting surface which is opposite the bulbar conjunctiva contacting surface, a therapeutic storage reservoir, and at least one fluid delivery port. In addition, a fill system for a liquid filled device includes a liquid feed tube, a plug rod feed tube, a junction port for the liquid feed tube and plug rod feed tube to meet, a needle output to temporarily interface with an ophthalmic liquid delivery device during the filling and plug step, and a cutting tool to cut the plug rod once the device is filled.

Abstract: An ophthalmic device for illuminating an interior region of a patient's eye includes a polymeric, at least partially transparent body having a first surface contoured to substantially conform to an ocular surface and a second surface opposed to the first surface; a light source; and an optical element for directing light through the first surface such that, with the first surface in contact with a corneal surface of the patient's eye, a portion of interior region of the patient's eye illuminated by the light source is visible through the first and second surfaces. In certain embodiments, the light source is sufficient to illuminate the retina so that an ophthalmic surgeon may view the eye during an evaluation or surgical procedure without the need for invasive probes, cameras, or other equipment.

Abstract: In various embodiments, a drug pump includes a housing and, within the housing, an expandable drug reservoir at least part of which is exposed to a pressurized propellant. The propellant exerts a substantially constant pressure on the drug reservoir. A flow restrictor significantly limits outflow from the pump, and preferably has both a small diameter and a long path length, which acts to control the outflow from the drug reservoir. As a result, the pump produces a substantially constant outflow.

Abstract: Embodiments of the present invention involve a refill apparatus comprising at least one pump, a plurality of reservoirs, a plurality of reservoir fluid channels each associated with one of the reservoirs, a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel, an outlet fluid channel fluidically connected to the reservoir fluid channels, and a needle having a lumen in fluid communication with the outlet fluid channel. A parameter such as a pressure level is monitored, and one or more pumps and various ones of the valves are actuated in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.

Abstract: Predictive healthcare systems utilize the signal produced by physiological and, in some embodiments, environmental sensors to infer, computationally, a physiological parameter of the patient. The physiological sensors may include a vibro-acoustic sensor in contact with a patient over at least the frequency band 0.001 Hz to 40 kHz and a bio-electric sensor. The physiological parameter may be the magnitude or existence of an internal process, such as blood flow; the presence of a biomarker; or the existence or likelihood of a disease. In some embodiments, the computational inference is based on additional data such as the patient's position and orientation and/or historical health information of the patient.

Abstract: A removable material is deposited or otherwise applied to a flat substrate surface in a pattern corresponding to desired corrugations in a membrane, e.g., a deflection diaphragm. The applied material serves as a scaffold for a polymeric material, which is applied thereover, and following cure or hardening, the polymeric material is removed to form a finished corrugated membrane.

Abstract: Embodiments of the present invention involve a refill apparatus comprising at least one pump, a plurality of reservoirs, a plurality of reservoir fluid channels each associated with one of the reservoirs, a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel, an outlet fluid channel fluidically connected to the reservoir fluid channels, and a needle having a lumen in fluid communication with the outlet fluid channel. A parameter such as a pressure level is monitored, and one or more pumps and various ones of the valves are actuated in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.

Abstract: Fluid-filled accommodating intraocular lenses include components enabling the lens to effectively respond to the eye's natural accommodation process, thereby allowing the patient to visualize over a range of focal distances with minimal complications. Internal components may include, for example, a rigid member that alters optical power of the lens and/or a spanning member extending across the lens that affects the response to accommodative action and/or to filling, or overfilling, of the lens with an optical fluid. Various combinations of internal and external components may be implanted in distinct successive steps or during separate operations to minimize complications and incision size.

Abstract: Excess gas generated by and within electrolytic drug-pump devices is managed by strategically facilitating catalytic recombination or sequestration of excess electrolysis gases in void regions where such gases are most likely to accumulate.

Abstract: Embodiments of the present invention involve a refill apparatus comprising at least one pump, a plurality of reservoirs, a plurality of reservoir fluid channels each associated with one of the reservoirs, a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel, an outlet fluid channel fluidically connected to the reservoir fluid channels, and a needle having a lumen in fluid communication with the outlet fluid channel. A parameter such as a pressure level is monitored, and one or more pumps and various ones of the valves are actuated in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.

Abstract: A removable material is deposited or otherwise applied to a flat substrate surface in a pattern corresponding to desired corrugations in a membrane, e.g., a deflection diaphragm. The applied material serves as a scaffold for a polymeric material, which is applied thereover, and following cure or hardening, the polymeric material is removed to form a finished corrugated membrane.