Abstract: A one-use, tamper-evident and tamper-proof package with an adhesive, seal-assist zip closure. The zip closure with an adhesive seal assist is suitable for transporting valuable and/or important items in a secure manner. The subject zip closure is a pressure joined, interlocking assembly. The interlocking assembly also comprises an adhesive, such as a microencapsulated adhesive or other specialty adhesive, that is activated when the interlocking zip assembly is secured. The adhesive provides a seal assist that prevents the interlocking assembly from being opened without tampering with or otherwise opening the packaging in a non-reusable manner.