Abstract: Systems and methods for providing multiple lumens within a single sample probe of an autosampler system are described. In an aspect, a sample probe for an autosampler system includes, but is not limited to, a tube enclosing at least a portion of a plurality of lumens; and a controller communicatively coupled with a fluid handling system to introduce or draw one or more fluids through each of the plurality of lumens, wherein during a droplet purge operation, the controller is configured to expel a gas from a tip of one of the lumens to purge a droplet of fluid from the tip.

Abstract: A method for determining how using a respiratory therapy system impacts sleep sessions of a user, includes receiving first activity information corresponding to actions of a user occurring prior to a use of the respiratory therapy system by the user. The first activity information includes activity information associated with use of a mobile device by the user prior to the use of the respiratory therapy system. The method also includes receiving second activity information corresponding to actions of the user occurring after the use of the respiratory therapy system. The second activity information includes activity information associated with use of the mobile device by the user after the use of the respiratory therapy system, as well as respiratory information generated by the respiratory therapy system during a sleep session of the user when using the respiratory therapy system.

Abstract: The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

Abstract: A gas turbine engine includes a rotatably driven engine component including a shaft coupling. The shaft coupling defines a first axial centerline and includes an inner surface. The inner surface includes a plurality of internal splines extending radially inwardly from the inner surface with respect to the first axial centerline. The engine further includes a driving member having a driving end portion and defining a second axial centerline. The driving end portion includes an outer surface and a plurality of external splines extending radially outwardly from the outer surface with respect to the second axial centerline. The plurality of external splines is drivingly engaged with the plurality of internal splines. The plurality of internal splines or the plurality of external splines comprises bowed splines.

Abstract: A humidification system for delivering humidified gases to a user can include a heater base, humidification chamber having an inlet, outlet, and associated fluid conduit, and breathing circuit including a supply conduit, inspiratory conduit, and optional expiratory conduit. The humidification system can include various features to help make set-up less difficult and time-consuming. For example, the supply conduit, inspiratory conduit, and optional expiratory conduit can be coupled into a one-piece circuit to aid set-up. Various components can be color-coded and can have corresponding structures to indicate which components should be connected to one another during set-up. Such features can also help make the set-up process more intuitive for an operator, which can reduce the need for specialized training and reduce the number of potential errors.

Abstract: A light detection and ranging (LIDAR) sensor system for a vehicle includes a transmitter, a receiver, and a scanner. The transmitter is configured to output a transmit beam. The transmitter includes a first grating coupler. The receiver includes a plurality of second grating couplers spaced apart from the first grating coupler.

Abstract: A medical imaging device for use in imaging a subject using both gamma rays and light rays emanating from the subject, the device comprising: separation means to separate gamma rays and light rays emanating from the subject into a gamma ray channel comprising gamma rays and a light ray channel comprising light rays; first sensor means arranged to receive and detect gamma rays from the gamma ray channel and to generate first signals for use in forming a first image of the subject; second sensor means arranged to receive and detect light rays from the light ray channel and to generate second signals for use in forming a second image of the subject; wherein the first sensor means and the second sensor means are arranged to receive gamma rays and light rays, respectively, which propagate from the subject upon substantially coincident paths.

Abstract: The present disclosure relates to compounds of Formula (Ia) and (Ib): or a pharmaceutically acceptable salt thereof, which are useful in the treatment of an HIV infection in heavily treatment-experienced patients with multidrug resistant HIV infection.

Abstract: A computer system is provided. The computer system includes a memory and at least one processor coupled to the memory and configured to deploy public key enumeration code and private key enumeration code to a plurality of endpoint devices for execution on the endpoint devices. The at least one processor is further configured to collect public keys and associated public key metadata from the endpoint devices, and to collect private key metadata from the endpoint devices. The public keys and associated public key metadata are generated by the public key enumeration code and the private key metadata is generated by the private key enumeration code. The at least one processor is further configured to generate a graph illustrating trust relationships between user accounts on the endpoint devices. The graph is based on the collected public keys, the collected public key metadata, and the collected private key metadata.

Abstract: A system and method for sensing an edge of a region includes at least one distance sensor configured to detect a plurality of distances of objects along a plurality of adjacent scan lines. A controller is in communication with the at least one distance sensor and is configured to determine a location of an edge of a region within the plurality of adjacent scan lines. The controller includes a comparator module configured to compare values corresponding to the detected plurality of distances, and an identification module configured to identify the location of the edge of the region according to the compared values. In one example, the values corresponding to the detected plurality of distances include couplets of standard deviations that are analyzed and selected to identify the location of the edge.

Abstract: A system, method, and computer-readable medium for evaluating structural integrity of a gradient coil disposed in a magnetic resonance imaging system is provided. A sensor obtains a parameter reading of the gradient coil, wherein the parameter reading includes a back electromotive force (back EMF) measurement. The structural integrity of the gradient coil is determined as function of the back EMF measurement.

Abstract: A clutched pulley assembly mountable to the shaft of a motor-generator unit (MGU) has a first sheave, with first spline teeth, rotatably mounted to the MGU shaft, and a second sheave, with second spline teeth, fixed to the MGU shaft. A slider gear with slider gear spline teeth is axially moveable between a torque transfer position, where the slider gear spline teeth simultaneously intermesh with the spline teeth of the first and second sheaves to operatively connect the sheaves to each other, and a torque cut-off position, where the slider gear spline teeth intermesh with the second sheave spline teeth but not the first sheave spline teeth so as to operatively disconnect the sheaves. An actuator drives the slider gear between the torque transfer and cut-off positions. The pulley assembly can be used in a stand-cooling mode wherein the engine is stopped but the MGU powers a load.

Abstract: A marine vessel has AC generators and AC loads connected by circuit breakers to first and second AC bus systems respectively. First and second galvanic isolators, which include bidirectional AC/DC inverters are connected to each other and respectively connected to the first and second bus systems. As a result, power may be transferred to and from multiple galvanically isolated AC bus systems and to and from DC energy storage systems while maintaining DP-2 requirements.

Abstract: A network node in a peer-to-peer network of nodes includes at least one processor, at least one memory, and at least one network interface. The at least one processor is configured to receive a request to transfer a security token and execute a plurality of compliance rules associated with the security token. At least one of the compliance rules is implemented using at least one smart contract. The at least one smart contract references a global registry. The at least one processor is also configured to transfer the security token based on the execution of the compliance rules. The global registry includes personally identifiable information (PII) hash(es) for each of at least one investor associated with the transfer of the security token. The hashes are committed to the distributed ledger and updated when PII of a respective one of the at least one investor changes.

Abstract: Apparatus for performing impedance measurements on a subject. The apparatus includes a first processing system for determining an impedance measurement procedure and determining instructions corresponding to the measurement procedure. A second processing system is provided for receiving the instructions, using the instructions to generate control signals, with the control signals being used to apply one or more signals to the subject. The second processing system then receives first data indicative of the one or more signals applied to the subject, second data indicative of one or more signals measured across the subject and performs at least preliminary processing of the first and second data to thereby allow impedance values to be determined.

Abstract: Antibody molecules that specifically bind to APRIL are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as IgA nephropathy.

Abstract: A workstation holding one or more electronic devices, e.g., a display, keyboard, or the like, can be mounted on a structure, e.g., a wall, using an articulating arm assembly including one or more arms. The one or more arms can be rotatingly coupled to the structure on one end and a work surface can be coupled to the other end. At least one of the one or more arms can be height adjustable. The workstation can rotate about a horizontal axis between a use configuration and a storage configuration. The one or more arms can be configured to translate the workstation between a contracted orientation and extended orientation. The height adjustable arm can include a counterbalance mechanism to counter a weight of the one or more components coupled to the workstation. A tension of the one or more springs contained in the counterbalance mechanism can be adjustable.

Abstract: A quantum key distributed (QKD) apparatus for use with at least two endpoint devices, the apparatus including QKD links each having a communication medium with a quantum channel and a classical channel, wherein each endpoint has a QKD link connected to the QKD apparatus; transmitters to transmit quantum transmissions over a quantum channel of one of the QKD links; a classical transceiver component to transmit/receive classical data over a classical channel of one of the QKD links; and a controller to route data for quantum transmission to an endpoint via a transmitter assigned to the endpoint over a quantum channel of the QKD link of the endpoint, route classical data to an endpoint via a classical transceiver assigned to the endpoint over a classical channel of the QKD link of the endpoint, and route classical data over the classical channel of the QKD link of an endpoint.

Abstract: An ignition system for a vehicle internal combustion engine (12) has a capsule defining a pre-chamber (136), an ignition fuel supply system (500) configured to inject an ignition fuel to the pre-chamber to create an ignition fuel-air mix in the pre-chamber, an ignition surface (137) within the pre-chamber, the ignition surface being defined by an interior surface of the capsule and configured to be contacted by the ignition fuel in the pre-chamber to thereby ignite the ignition fuel by hot surface ignition, and at least one jet nozzle (152). The ignition fuel is characterised by having a carbon content by mass less than 65%, a hot surface ignition temperature less than 500 deg C., and a volumetric energy density (LHV) greater than 18 MJ/L. The at least one jet nozzle is configured such that ignition of the ignition fuel by contact with the ignition surface causes at least one of hot gases, partially combusted fuel and flames to leave the pre-chamber through the at least one jet nozzle.

Abstract: The present document relates to methods and apparatus for rendering input audio for playback in a playback environment. The input audio includes at least one audio object and associated metadata, and the associated metadata indicates at least a location of the audio object. A method for rendering input audio including divergence metadata for playback in a playback environment comprises creating two additional audio objects associated with the audio object such that respective locations of the two additional audio objects are evenly spaced from the location of the audio object, on opposite sides of the location of the audio object when seen from an intended listener's position in the playback environment, determining respective weight factors for application to the audio object and the two additional audio objects, and rendering the audio object and the two additional audio objects to one or more speaker feeds in accordance with the determined weight factors.