Patents by Inventor Andrey Simbirtsev

Andrey Simbirtsev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-marinobufagenin antibodies and methods for their use
    Patent number: 8038997
    Abstract: Described herein are deposited hybridoma cell lines and the monoclonal antibodies produced by these hybridomas, and antigen binding fragments thereof. These monoclonal antibodies and antigen binding fragments specifically bind marinobufagenin. The disclosure also encompasses the use of these monoclonal antibodies or antigen binding fragments in a method for detecting the presence of marinobufagenin in a biological sample. Also provided are methods for the use of these monoclonal antibodies or antigen binding fragments as prophylactic, therapeutic, and diagnostic agents for the detection, inhibition and treatment of a cardiovascular disease, for example, essential hypertension, hypertension associated with preeclampsia, eclampsia, or renal failure, or myocardial fibrosis in a subject.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: October 18, 2011
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Alexei Bagrov, Olga V. Fedorova, Edward G. Lakatta, Andrey Simbirtsev, Alexander Kotov, Nikolai Kolodkin
  • ANTI-MARINOBUFAGENIN ANTIBODIES AND METHODS FOR THEIR USE
    Publication number: 20100158900
    Abstract: Described herein are deposited hybridoma cell lines and the monoclonal antibodies produced by these hybridomas, and antigen binding fragments thereof. These monoclonal antibodies and antigen binding fragments specifically bind marinobufagenin. The disclosure also encompasses the use of these monoclonal antibodies or antigen binding fragments in a method for detecting the presence of marinobufagenin in a biological sample. Also provided are methods for the use of these monoclonal antibodies or antigen binding fragments as prophylactic, therapeutic, and diagnostic agents for the detection, inhibition and treatment of a cardiovascular disease, for example, essential hypertension, hypertension associated with preeclampsia, eclampsia, or renal failure, or myocardial fibrosis in a subject.
    Type: Application
    Filed: June 26, 2006
    Publication date: June 24, 2010
    Inventors: Alexei Bagrov, Olga V. Fedorova, Edward G. Lakatta, Andrey Simbirtsev, Alexander Kotov, Nikolai Kolodkin
  • TREATMENT OR PREVENTION OF RESPIRATORY VIRAL INFECTIONS WITH IMMUNOMODULATOR COMPOUNDS
    Publication number: 20070087974
    Abstract: An immunomodulatory compound is administered to a patient having, or at risk of a respiratory viral infection.
    Type: Application
    Filed: November 9, 2006
    Publication date: April 19, 2007
    Applicant: SCICLONE PHARMACEUTICALS, INC.
    Inventors: Cynthia TUTHILL, Alfred RUDOLPH, Alexander KOLOBOV, Andrey SIMBIRTSEV, Aleksandr PETROV