Abstract: A method of modifying or treating biological tissue by microperforating hard tissue is disclosed. The method comprises identifying a target area associated with the hard tissue, using a laser beam to perforate at least one incision in the hard tissue, wherein at least one incision has a diameter from a range of 0.001 mm to 0.5 mm and an aspect ratio from a range of 1 to 100 times, introducing a treatment substance into the incision, and causing the treatment substance to interact with the target area. Also a device for microperforating hard biological tissue is disclosed, comprising a laser pump system and a laser head coupled to the laser pump system for generating a pulsed laser having ranges of wavelengths, a pulse duration, pulse energy from a selected range, a beam divergence factor less than 5, a repetition rate higher than 50 Hz; and a beam delivery system comprised of a focusing system for creating a beam having a diameter from a range of 0.001 mm to 0.5 mm.