Abstract: Provided herein are KRAS protein degraders, for example, a compound of Formula (A), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a KRAS-mediated disorder, disease, or condition.

Abstract: Provided herein are KRAS protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a KRAS-mediated disorder, disease, or condition.

Abstract: Provided herein are SOS1 protein degraders, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of an SOS1-mediated disorder, disease, or condition.

Abstract: This disclosure describes a card-scan system that can update a card-scan machine learning model to improve card-character predictions for payment cards, driver licenses, or other character-bearing cards by using an active-learning technique that learns from card-scan representations indicating corrections by users to predicted card characters. In particular, the disclosed systems can use a client device to capture and analyze a set of card images of a character-bearing card to predict card characters using a card-scan machine learning model. The disclosed systems can further receive card-scan gradients representing one or more corrections to incorrectly predicted card characters. Based on the card-scan gradients, the disclosed systems can generate active-learning metrics and retrain or update the card-scan machine learning model based on such active-learning metrics.

Abstract: Electronic devices, interfaces for electronic devices, and techniques for interacting with such interfaces and electronic devices are described. For instance, this disclosure describes an example electronic device that includes sensors, such as multiple front-facing cameras to detect orientation and/or location of the electronic device relative to an object and one or more inertial sensors. Users of the device may perform gestures on the device by moving the device in-air and/or by moving their head, face, or eyes relative to the device. In response to these gestures, the device may perform operations.

Abstract: Electronic devices, interfaces for electronic devices, and techniques for interacting with such interfaces and electronic devices are described. For instance, this disclosure describes an example electronic device that includes sensors, such as multiple front-facing cameras to detect orientation and/or location of the electronic device relative to an object and one or more inertial sensors. Users of the device may perform gestures on the device by moving the device in-air and/or by moving their head, face, or eyes relative to the device. In response to these gestures, the device may perform operations.

Abstract: Systems, methods, and computer-readable media are disclosed for detecting handwritten text on a writing surface, determining one or more layout and/or content attributes of the handwritten text, determining application functionality that corresponds to the layout and/or content attribute(s), executing the application functionality to obtain an execution result, and presenting an indication of the execution result on the writing surface in association with at least a portion of the handwritten text.

Abstract: Systems, methods, and computer-readable media are disclosed for generating personalized and contextually relevant cards and delivering the cards to card clients for presentation to a user.

Abstract: Systems, methods, and computer-readable media are disclosed for generating cards that include personalized content that is relevant to tastes or preferences of a user and contextually relevant to a current, historical, or future use context of a user device. The card content is determined to be relevant to a current use context of a user device based on an evaluation of contextual data with respect to constraints associated with the card. The card content is transmitted to a card client for presentation via a user interface of the client when the card content is deemed relevant to the current use context of the device.

Abstract: Systems, methods, and computer-readable media are disclosed for generating personalized and contextually relevant cards and delivering the cards to card clients for presentation to a user.

Abstract: Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additional antiviral agents, in a therapeutically effective amount.