Patents by Inventor Angela R Reynolds

Angela R Reynolds has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified polynucleotides for reducing off-target effects in RNA interference
    Patent number: 7834171
    Abstract: Methods and compositions for performing RNA interference with decreased off-target effects are provided. The methods and compositions permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of modifications to the siRNA. Uniquely modified siRNAs have been developed that reduce off-target effects incurred in gene-silencing. The modifications comprise 2?-O-alkyl or mismatch modification(s) at specific positions on the sense and/or antisense strands.
    Type: Grant
    Filed: September 19, 2007
    Date of Patent: November 16, 2010
    Assignee: Dharmacon, Inc.
    Inventors: Devin Leake, Angela R Reynolds, Anastasia Khvorova, William Marshall