Abstract: Provided herein are methods and compositions for preventing small molecule permeability of the small intestine curing total ischemia by administering glucose to the lumen of the intestine, as well as administration of serine protease or metalloproteinase inhibitors. Also provided are compositions for performing the same.

Abstract: Devices, systems and methods are disclosed which relate to training a user in controlling and limiting total calorie consumption, and consequently body weight, by encouraging the user to perform specified consuming actions such as chewing slowly, adjusting a time interval between bites, detecting the early points of satiation, etc. The disclosure is therefore a “calorie pacer” that naturally reduces calorie consumption by re-teaching a user how to eat on a step-by-step basis. The slower eating pace results in a person feeling full before the intake of excessive food portions. The result is fewer calories consumed. Sensors and microcontrollers throughout a place setting are utilized to prompt the user, for example, when to take bites, how big of a bite to take, when to take a drink, etc and record the data in an efficient manner that allows for analysis, monitoring of progress, and personalized feedback.

Abstract: Devices, systems and methods are disclosed which relate to training a user in controlling and limiting total calorie consumption, and consequently body weight, by encouraging the user to perform specified consuming actions such as chewing slowly, adjusting a time interval between bites, detecting the early points of satiation, etc. The disclosure is therefore a “calorie pacer” that naturally reduces calorie consumption by re-teaching a user how to eat on a step-by-step basis. The slower eating pace results in a person feeling full before the intake of excessive food portions. The result is fewer calories consumed. Sensors and microcontrollers throughout a place setting are utilized to prompt the user, for example, when to take bites, how big of a bite to take, when to take a drink, etc and record the data in an efficient manner that allows for analysis, monitoring of progress, and personalized feedback.