Abstract: A cooling system is provided. The cooling system includes a condenser configured to condense a coolant from a vapor state to a liquid state and an evaporator configured to evaporate the coolant from the liquid state to the vapor state. The evaporator defines a reservoir configured to contain a volume of the coolant in the liquid state. The cooling system further includes a vapor channel fluidly coupled to the condenser and the evaporator and configured to convey the coolant in the vapor state from the evaporator to the condenser, a liquid channel coupled to the condenser and the evaporator and configured to convey the coolant in the liquid state from the condenser to the evaporator, and a heat generating component disposed in the reservoir and immersed in the volume of the coolant in the liquid state. The heat generating component is configured to dissipate heat into the coolant.

Abstract: A cooling system is provided. The cooling system includes a condenser configured to condense a coolant from a vapor state to a liquid state and an evaporator configured to evaporate the coolant from the liquid state to the vapor state. The evaporator defines a reservoir configured to contain a volume of the coolant in the liquid state. The cooling system further includes a vapor channel fluidly coupled to the condenser and the evaporator and configured to convey the coolant in the vapor state from the evaporator to the condenser, a liquid channel coupled to the condenser and the evaporator and configured to convey the coolant in the liquid state from the condenser to the evaporator, and a heat generating component disposed in the reservoir and immersed in the volume of the coolant in the liquid state. The heat generating component is configured to dissipate heat into the coolant.

Abstract: A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.

Abstract: A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.

Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.

Abstract: A centrifugal separator includes an outer tube, an inner tube, an outlet pipe, and a control mechanism. The outer tube defines at least one outer tube inlet and at least one outer tube outlet. The inner tube is disposed within the outer tube. The inner tube is configured to separate the flow of a first fluid into the flow of a second fluid and a flow of a third fluid by rotation thereof. The outlet pipe is partially disposed within the inner tube and the outer tube. The outlet pipe includes a cross-sectional area. The outlet pipe is configured to channel the flow of the third fluid out of the inner tube and the outer tube. The control mechanism is coupled to the outlet pipe. The control mechanism is configured to regulate the flow of the third fluid by changing the cross-sectional area of the outlet pipe.

Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.

Abstract: A system for isolating a target molecule from a bioprocess fluid includes a single-use disposable separation device having a plurality of perimeter-bonded layers defining one or more mesofluidic channels of the separation device, wherein each layer includes a biocompatible polymer material, wherein the separation device is configured to separate at least a portion of particles from the bioprocess fluid to generate a substantially clarified bioprocess fluid, and a chromatography system fluidically coupled at the outflow of the separation device in a configuration for further processing the clarified bioprocess fluid.

Abstract: A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.

Abstract: A control system for a CO2 fracking system includes a phase detector, a control valve, and a controller. The phase detector is disposed proximate to at least one of an inlet conduit and an outlet conduit of a fracking component. The control valve is fluidly coupled to the inlet conduit. The controller is communicatively coupled to the phase detector, the control valve, and the fracking component. The phase detector is configured to determine CO2 phase in at least one of a CO2 stream incoming into the fracking component and CO2 phase discharged from the fracking component, and to generate an input signal based on the phase. The controller is configured to control one or both of a flow of the incoming CO2 stream into the fracking component via the control valve and an operation condition of the fracking component, based on the input signal received from the phase detector.

Abstract: A centrifugal separator includes an outer tube, an inner tube, an outlet pipe, and a control mechanism. The outer tube defines at least one outer tube inlet and at least one outer tube outlet. The inner tube is disposed within the outer tube. The inner tube is configured to separate the flow of a first fluid into the flow of a second fluid and a flow of a third fluid by rotation thereof. The outlet pipe is partially disposed within the inner tube and the outer tube. The outlet pipe includes a cross-sectional area. The outlet pipe is configured to channel the flow of the third fluid out of the inner tube and the outer tube. The control mechanism is coupled to the outlet pipe. The control mechanism is configured to regulate the flow of the third fluid by changing the cross-sectional area of the outlet pipe.

Abstract: A centrifugal separator for separating a mixed stream including a first fluid and a second fluid. The separator includes a housing that extends from a first end to a second end. A first flow opening is at the first end, a second flow opening is at the second end, and a third flow opening is at the second end. A rotor assembly within the housing includes a rotor shaft and a cylindrical drum. The cylindrical drum includes an interior including an outer radial portion and an inner radial portion. The outer radial portion is in flow communication with the first flow opening and the second flow opening, and the inner radial portion is in flow communication with the third flow opening. The cylindrical drum is rotatable within the housing such that the first fluid flows along the outer radial portion, and such that the second fluid flows along the inner radial portion.

Abstract: A control system for a CO2 fracking system includes a phase detector, a control valve, and a controller. The phase detector is disposed proximate to at least one of an inlet conduit and an outlet conduit of a fracking component. The control valve is fluidly coupled to the inlet conduit. The controller is communicatively coupled to the phase detector, the control valve, and the fracking component. The phase detector is configured to determine CO2 phase in at least one of a CO2 stream incoming into the fracking component and CO2 phase discharged from the fracking component, and to generate an input signal based on the phase. The controller is configured to control one or both of a flow of the incoming CO2 stream into the fracking component via the control valve and an operation condition of the fracking component, based on the input signal received from the phase detector.