Abstract: The present disclosure relates to a water-based cosmetic composition thickened with xanthan gum and sodium carboxymethyl cellulose, having a strongly alkaline pH, to be used as an alkalizing component in a two- or three-part oxidative hair lightening agent.

Abstract: The present disclosure relates to a water-based cosmetic composition thickened with xanthan gum and sodium carboxymethyl cellulose and having a strongly alkaline pH, to be used as an alkalizing component in a two-part oxidative hair dye.

Abstract: The object of the present disclosure are agents for oxidative hair bleaching with a pH value in the range from about 10.0 to about 11.0, containing from about 70-95% by weight of water, an alkalizing agent, from about 0.1-2% by weight of anionic, zwitterionic or amphoteric surfactant, from about 0.1-1.5% by weight of sodium polyacrylate, wherein only small amounts, if any, of linear saturated alkanols having two or three hydroxy groups and from 2 to 8 carbon atoms in the alkyl group are included. Furthermore, no saturated and unsaturated non-alkoxylated alkanols having one hydroxy group and from 1 to 50 carbon atoms in the alk(en)yl group, no saturated and unsaturated alkanecarboxylic acids with 1 to 50 carbon atoms, no crosslinked copolymer built up from acrylic acid and non-ethoxylated esters of acrylic acid with linear C10-C30 monoalcohols as monomers and no oxidizing agents are contained.

Abstract: The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterizing the proliferation properties of the respective cell. The characterization of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.

Abstract: The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterizing the proliferation properties of the respective cell. The characterization of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.

Abstract: The object of the present disclosure are agents for oxidative hair bleaching with a pH value in the range from about 10.0 to about 11.0, containing from about 70-95% by weight of water, an alkalizing agent, from about 0.1-2% by weight of anionic, zwitterionic or amphoteric surfactant, from about 0.1-1.5% by weight of sodium polyacrylate, wherein only small amounts, if any, of linear saturated alkanols having two or three hydroxy groups and from 2 to 8 carbon atoms in the alkyl group are included. Furthermore, no saturated and unsaturated non-alkoxylated alkanols having one hydroxy group and from 1 to 50 carbon atoms in the alk(en)yl group, no saturated and unsaturated alkanecarboxylic acids with 1 to 50 carbon atoms, no crosslinked copolymer built up from acrylic acid and non-ethoxylated esters of acrylic acid with linear C10-C30 monoalcohols as monomers and no oxidizing agents are contained.

Abstract: This invention provides methods and kits for improved diagnosis of medically relevant conditions by solution based biochemical testing procedures performed in solutions of test samples. The invention provides a method to substitute the cell based morphological information contained within the cytological and/or histological data of the test sample by molecular information obtainable from the solution, wherein the original test sample is dissolved and thus enables for accurate and reproducible assessment of medically relevant diagnosis from dissolved test samples. The method according to the invention comprises the steps of determining the levels of one or more disease markers associated with the condition to be diagnosed, determining the level of one or more normalization markers suitable to substitute the information related to morphological aspects of the sample, comparing and/or combining the data of the disease and normalization markers, and assessing diagnosis of a medically relevant condition.

Abstract: The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterizing the proliferation properties of the respective cell. The characterization of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.

Abstract: The subject matter of the present disclosure is a method for the oxidative lightening and/or dyeing of keratinous fibers, more particularly of hair, wherein a) a dye and/or lightening agent is applied to the keratinous fiber, said dye or lightening agent being obtained by mixing a composition (A), which contains at least one alkalizing agent, with a composition (B), which contains, in a cosmetic carrier, at least one oxidant, b) thereafter, within a period of one second to 24 hours after step a), a pre-treatment agent containing at least one salt of an isoalkylphosphoric acid ester, is applied to the keratinous fibers, more particularly the hair.

Abstract: The subject matter of the present disclosure is a method for the oxidative lightening and/or dyeing of keratinous fibers, more particularly of hair, wherein a) a dye and/or lightening agent is applied to the keratinous fiber, said dye or lightening agent being obtained by mixing a composition (A), which contains at least one alkalizing agent, with a composition (B), which contains, in a cosmetic carrier, at least one oxidant, b) thereafter, within a period of one second to 24 hours after step a), a pre-treatment agent containing at least one salt of an isoalkylphosphoric acid ester, is applied to the keratinous fibers, more particularly the hair.

Abstract: The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterizing the proliferation properties of the respective cell. The characterization of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.

Abstract: An agent for coloring and/or lightening keratinic fibers, in particular human hair, includes: (a) ammonia in a quantity of 0.40 to 3.0 wt.-%, preferably of 0.50 to 2.4 wt.-%, more preferably of 0.60 to 2.0 wt.-% and especially preferred of 0.62 to 1.75 wt.-%, based on the weight of the agent, (b) one or more alkanolamines from the group of monoethanolamine, 2-amino-2-methylpropanol, and triethanolamine, (c) one or more ethoxylated fatty alcohols having a degree of ethoxylation from 80 to 120, (d) cetyl alcohol and stearyl alcohol in a total quantity of 4 to 8 wt-%, based on the weight of the agent, (e) one or more ethoxylated fatty alcohols having a degree of ethoxylation of 30.

Abstract: An agent for coloring and/or lightening keratinic fibers, in particular human hair, includes: (a) ammonia in a quantity of 0.40 to 3.0 wt.-%, preferably of 0.50 to 2.4 wt.-%, more preferably of 0.60 to 2.0 wt.-% and especially preferred of 0.62 to 1.75 wt.-%, based on the weight of the agent, (b) one or more alkanolamines from the group of monoethanolamine, 2-amino-2-methylpropanol, and triethanolamine, (c) one or more ethoxylated fatty alcohols having a degree of ethoxylation from 80 to 120, (d) cetyl alcohol and stearyl alcohol in a total quantity of 4 to 8 wt-%, based on the weight of the agent, (e) one or more ethoxylated fatty alcohols having a degree of ethoxylation of 30.

Abstract: The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterizing the proliferation properties of the respective cell. The characterization of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.

Abstract: This invention provides methods and kits for improved diagnosis of medically relevant conditions by solution based biochemical testing procedures performed in solutions of test samples. The invention provides a method to substitute the cell based morphological information contained within the cytological and/or histological data of the test sample by molecular information obtainable from the solution, wherein the original test sample is dissolved and thus enables for accurate and reproducible assessment of medically relevant diagnosis from dissolved test samples. The method according to the invention comprises the steps of determining the levels of one or more disease markers associated with the condition to be diagnosed, determining the level of one or more normalization markers suitable to substitute the information related to morphological aspects of the sample, comparing and/or combining the data of the disease and normalization markers, and assessing diagnosis of a medically relevant condition.

Abstract: The subject matter of the present Application is cosmetic agents for treating keratinic fibers, which encompass at least two phases present alongside one another but separated from one another by a phase boundary, where the first phase (I) represents an aqueous phase that contains at least one chemical oxidizing agent, and where the second phase (II) represents a hydrophobic oil phase that contains a mixture of isopropyl palmitate (II-1) and at least one further liquid, branched carboxylic acid ester (II-2). The compositions are particularly shelf-stable and cold-stable, and are notable for outstanding care-providing properties.

Abstract: The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterizing the proliferation properties of the respective cell. The characterization of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens.

Abstract: Agent for oxidative coloring of keratinic fibers comprising a specific combination of non-ionic emulsifiers with a differing degree of ethoxylation and a specific combination of interfacially active substances comprising at least one anionic, at least one zwitterionic and at least one amphoteric surfactant. The agents provide good coloring characteristics while simultaneously protecting against damage to human hair. In particular the agents allow for colors with high color intensity and an improved gray coverage. The agents also provide significant advantages with regard to viscosity stability during storage and use and an improvement in shear sensitivity.

Abstract: Agent for oxidative coloring of keratinic fibers comprising a specific combination of non-ionic emulsifiers with a differing degree of ethoxylation and a specific combination of interfacially active substances comprising at least one anionic, at least one zwitterionic and at least one amphoteric surfactant. The agents provide good coloring characteristics while simultaneously protecting against damage to human hair. In particular the agents allow for colors with high color intensity and an improved gray coverage. The agents also provide significant advantages with regard to viscosity stability during storage and use and an improvement in shear sensitivity.

Abstract: Agent for changing the color and/or permanently changing the shape of keratinic fibers, wherein the agent contains in a cosmetic carrier at least one color- and/or shape-changing component as well as an animal-based care agent, in particular royal jelly, in combination with a polyalkoxylated fatty substance. The agents are suitable for reducing hair damage which occurs in connection with oxidative hair treatment such as oxidative hair coloring, hair lightening and perming.