Abstract: Methods, devices, and systems are provided for guiding tumor movement, particularly in vivo for treatment of patients. The method may include implanting into a tissue site where tumor cells are present a device having one or more surface structures or substrates, such as aligned nanofibers, which provide physical guidance cues for directing the migration of the tumor cells from the first tissue location to a selected second location, for tumor cell extraction or death. The devices and systems may include a cytotoxic agent for contacting tumor cells migrated via the substrate. All or a portion of the at least one substrate may include one or more biochemical cues, such as a coating of laminin or another protein, which may be provided in a concentration gradient to facilitate uni-directional tumor cell migration.

Abstract: An array of biosensors diagnosing biomarkers device and a drug delivery vehicle system including a plurality of biosensor arrays for diagnosing biomarkers concentrations, and a delivery vehicle dispensing drug, a electronic interface, a plurality of algorithms to relate biomarker concentrations and drug dispensed, wherein biosensors in said plurality of biosensor arrays are constructed from quantum dot field-effect transistors, and wherein one or more layers of cladded quantum dots are assembled in the channel, gate, and channel and gate regions of FETs, and wherein quantum dots are functionalized by DNA aptamers, antisense oligoneuclotides (ASOs), and DNAs, to sense biomarkers concentrations comprising at least one of proteins, miRNAs, and genes, and wherein the concentrations of biomarkers changes and their values change the magnitude of drain current as a function of time, and wherein the drain current signal is processed by an electronic interface.

Abstract: Methods, devices, and systems are provided for guiding tumor movement, particularly in vivo for treatment of patients. The method may include implanting into a tissue site where tumor cells are present a device having one or more surface structures or substrates, such as aligned nanofibers, which provide physical guidance cues for directing the migration of the tumor cells from the first tissue location to a selected second location, for tumor cell extraction or death. The devices and systems may include a cytotoxic agent for contacting tumor cells migrated via the substrate. All or a portion of the at least one substrate may include one or more biochemical cues, such as a coating of laminin or another protein, which may be provided in a concentration gradient to facilitate uni-directional tumor cell migration.