Abstract: In some embodiments of the invention, inventive compounds (e.g., Formula (I), (IA), (II), and (III), and urolithin derivatives) are disclosed. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein.

Abstract: An example method includes: executing, by application analysis software executing in the virtualized computing system, process discovery agents on the VMs; receiving, at the application analysis software from the process discovery agents, process metadata describing processes executing on the VMs; generating signatures for the processes based on the process metadata; determining components of an application based on the signatures; determining components of an application based on the signatures; identifying, for a first component of the components, a component-specific metadata collector; executing, by the application analysis software, the component-specific metadata collector on a first VM of the VMs; and receiving, at the application analysis software from the component-specific metadata collector, custom metadata further describing a first process of the processes associated with the first component.

Abstract: The present invention relates to a pharmaceutical combination comprising a eyelin dependent kinase (CDK) inhibitor represented by a compound of formula I (as described herein) or a pharmaceutically acceptable salt thereof; and at least one anticancer agent selected from a BRAF inhibitor or a MEK inhibitor, for use in the treatment of melanoma. The present invention also relates to a method for the treatment of melanoma comprising administering to a subject in need thereof, a therapeutically effective amount of a CDK inhibitor and a therapeutically effective amount of at least one anticancer agent selected from a BRAF inhibitor or a MEK inhibitor.

Abstract: Provided herein are sustained release biodegradable ocular hydrogel implants which are useful for lowering ocular pressure and for treating related conditions.

Abstract: In some implementations, a system may receive a submission associated with an innovation associated with an entity. The system may analyze, using a first machine learning model, the submission to identify a classification associated with the innovation. The system may analyze, using a second machine learning model in association with the classification, content of the submission to identify a characteristic of the innovation. The system may determine, using a third machine learning model and based on the characteristic, a ranking of the innovation relative to individual innovations in the subset of innovations. The system may determine, using a fourth machine learning model, an impact score associated with the innovation. The system may perform, based on the impact score satisfying a threshold, an action associated with a project involving the innovation.

Abstract: This disclosure relates to methods, non-transitory computer readable media, and systems that generate and render a varied-scale-topological construct for a multidimensional dataset to visually represent portions of the multidimensional dataset at different topological scales. In certain implementations, for example, the disclosed systems generate and combine (i) an initial topological construct for a multidimensional dataset at one scale and (ii) a local topological construct for a subset of the multidimensional dataset at another scale to form a varied-scale-topological construct. To identify a region from an initial topological construct to vary in scale, the disclosed systems can determine the relative densities of subsets of multidimensional data corresponding to regions of the initial topological construct and select one or more such regions to change in scale.

Abstract: One or more engine instances are executed on each host to form an engine cluster. A plurality of control instances are executed on a first set of hosts to form a control cluster and comprise a control instance leader and one or more control instance followers. In response to a first host indicating a failure of a neighbor host, a pair-wise focused investigation is initiated to check peer-to-peer connections between the first host and the neighbor host. In response to one or more additional hosts indicating failures of neighbor hosts while the pair-wise focused investigation is being performed, a wide investigation is performed to check connections between the control cluster and the plurality of hosts. One or more hosts are added to an eviction list and an eviction protocol is performed to evict the one or more hosts from the engine cluster using the eviction list.

Abstract: Execution status of managed time series processing tasks may be tracked. Status of a time series processing task that operations on different portions of a time series may be respectively captured. A request for the status of one of the portions of the time series with respect to the time series processing task may be received. The status may be identified and returned. For failed tasks, a failure reason may be generated by the time series processing system and included in a response with a failure status.

Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.

Abstract: Differential signaling transmitter circuitry includes upper and lower driver stacks, each with at least one upper blocking transistor and a bias transistor, further includes first and second control loops. A first control loop includes a replica stack including replicas of the bias transistor and blocking transistors of a first one of the driver stacks, and a second control loop includes replica stacks, one with replicas of the bias and blocking transistors of the upper driver stack and one with replicas of the bias and blocking transistors of the lower driver stack. One of the replica stacks in the second control loop receives an output from the first control loop. First and second switching circuitry couples outputs of the first and second control loops to gates of bias transistor in the upper and lower driver stacks, respectively, responsive to a data signal.

Abstract: The present invention relates to novel trispecific heterodimeric immunoglobulins. More specifically the present invention relates to trispecific heterodimeric immunoglobulins that target human CD3 antigen, human BCMA and human CD38 antigen. The present invention also relates to this novel class of trispecific heterodimeric immunoglobulins for use in the treatment of proliferative diseases and in particular cancers such as hematological cancer. The present invention relates to novel trispecific antibody for use in treating multiple myeloma.

Abstract: Method and systems for securely and accurately authenticating a payment card by using biometric information associated with an authorized user is provided. The method may be implemented by providing a payment card that includes a processor; a display area coupled to the processor and configured to hide account information when the payment card has not been authenticated and to display the account information for a predetermined time interval when the payment card is authenticated; a sensor coupled to the processor and configured to capture biometric information of a user; and a communication interface coupled to the processor and configured to facilitate wireless communication with a mobile smart phone.

Abstract: A heart valve sizer and sizer cover are provided for determining the size of a heart valve annulus. The valve sizer can include a handle, a shaft extending distally from the handle, a sizing element coupled to the distal end of the shaft, the sizing element being movable between a first retracted position and a second expanded position, and a sizer cover. The sizer cover can be formed from a continuous sheet of material configured to surround at least a portion of the sizing element of the heart valve sizer so as to guard against entanglement of the sizing element with structures of a human heart.

Abstract: A method is described. The method includes receiving system level power information. The method includes causing a power supply unit's voltage conversion switching frequency to change based on the system level power information. The power supply unit supplies power to a system that includes at least a processor and memory. The system level power information describes power consumed by at least the processor and memory.

Abstract: A wick for a liquid electric vaporiser is disclosed. The wick comprises charcoal, inorganic minerals and water. Furthermore, the wick has a lower end and an upper end and is characterized in that the wick has a porosity between 24% and 44%, more preferably between 28% and 42%, and most preferably between 31% and 40% by volume. The wick exhibits a permeability between 3.2 and 9 mm per hour, more preferably between 3.8 and 8 mm per hour, and most preferably between 4 and 6 mm per hour, wherein the permeability is a measure of a vertical travel speed of a solvent liquid to travel from the lower end to the upper end of the wick by capillary action when the lower end of the wick is placed in a pool of the solvent liquid having a viscosity of between 1 and 10 cP, in particular between 1 and 4 cP, and a pool depth of about 2-4 mm. A liquid electric vaporiser including said wick is also disclosed.

Abstract: Certain aspects of the present disclosure provide techniques and apparatus for quantized machine learning. A quantized input matrix is accessed at a layer of a neural network, and a first interim value is generated in an accumulator by performing matrix multiplication, using the accumulator, of the quantized input matrix and a quantized weight matrix associated with the layer of the neural network. The first interim value is normalized based at least in part on one or more leading sign bits of the first interim value, and the normalized first interim value is dequantized. A second interim value is generated by applying a rounded right-shift operation to the dequantized normalized first interim value, and activation data is generated by applying an activation function to the second interim value.

Abstract: A service to provide anomaly detection receives a request to back-test the service. The request includes information for accessing a dataset of historical data. The service executes workflows to ingest the data, train a plurality of machine learning models to perform anomaly detection, and detect anomalies in the dataset. A representation of the detect anomalies is generated and presented to a user. The service receives an indication to activate the service to provide ongoing anomaly detection services.

Abstract: A method of testing an integrated circuit on a test circuit board includes performing, by a processor, a simulation of a first heat distribution throughout an integrated circuit design, and simultaneously performing a burn-in test of the integrated circuit and an automated test of the integrated circuit. The burn-in test has a minimum burn-in temperature of the integrated circuit or a burn-in heat distribution across the integrated circuit that includes a set of circuit blocks or a first set of heaters. The integrated circuit design corresponding to the integrated circuit. The performing the simulation includes determining a heat signature of the integrated circuit design from configured power information or location information for each circuit block of the set of circuit blocks or each heater of the set of heaters included in the integrated circuit design. The heat signature includes heat values distributed throughout the integrated circuit design.

Abstract: A first venous rhythm of a patient is detected above a venous insertion site when a venous catheter connected to an infusion set is inserted into the venous insertion site and, concurrently with the first venous rhythm, a second venous rhythm is detected at a location remote from the venous insertion site. An irregularity between the first and second venous rhythms is identified, and a failure of the venous catheter is determined based on the identified irregularity satisfying a irregularity threshold. An alarm may be provided on detecting the irregularity or the failure of the venous catheter.

Abstract: A method for adjusting the clarity of an audio output in a changing environment, including: receiving a content signal; applying a customized gain to the content signal; and outputting the content signal with the customized gain to at least one speaker for transduction to an acoustic signal, wherein the customized gain is applied on a per frequency bin basis such that frequencies of a lesser magnitude are enhanced with respect to frequencies of a greater magnitude and an intelligibility of the acoustic signal is set approximately at a desired level, wherein the customized gain is determined according to at least one of a gain applied to the content signal, a bandwidth of the content signal, and a content type encoded by the content signal.