Patents by Inventor Ann M. Madar

Ann M. Madar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates for substituted azetidinones useful as anti-inflammatory and antidegenerative agents
    Patent number: 5149838
    Abstract: Disclosed is a process for the enantioselective synthesis of the compound of Formula I and related compounds. The process comprises the synthesis of the benzofuranyl carboxaldehyde; introduction of the benzylic amine functionality with control of the absolute stereochemistry; preparation of the azetidinone fragment and its coupling to the benzofuranyl amine fragments. The carboxylic acid in Formula I is liberated using heterogenous palladium catalyzed de-allylation of the allyl esters. Compounds I have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents.
    Type: Grant
    Filed: September 20, 1991
    Date of Patent: September 22, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Guy R. Humphrey, Ann M. Madar, Andrew S. Thompson