Patents by Inventor Ann Tsukamoto

Ann Tsukamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENOME EDITING OF HUMAN NEURAL STEM CELLS USING NUCLEASES
    Publication number: 20230250423
    Abstract: The invention provides methods for generating a genetically modified human neural stem cell, genetically modified human neural stem cells, and pharmaceutical compositions comprising the genetically modified human neural stem cells. Also provided are associated kits. The invention also provides methods for preventing or treating a neurodegenerative disease or a neurological injury in a human subject using genetically modified human neural stem cells.
    Type: Application
    Filed: January 3, 2023
    Publication date: August 10, 2023
    Inventors: Matthew H. PORTEUS, Eric J. KILDEBECK, Daniel P. DEVER, Joseph T. CLARK, Ann TSUKAMOTO, Nobuko UCHIDA
  • GENOME EDITING OF HUMAN NEURAL STEM CELLS USING NUCLEASES
    Publication number: 20170298348
    Abstract: The invention provides methods for generating a genetically modified human neural stem cell, genetically modified human neural stem cells, and pharmaceutical compositions comprising the genetically modified human neural stem cells. Also provided are associated kits. The invention also provides methods for preventing or treating a neurodegenerative disease or a neurological injury in a human subject using genetically modified human neural stem cells.
    Type: Application
    Filed: April 13, 2017
    Publication date: October 19, 2017
    Inventors: Matthew H. PORTEUS, Eric J. KILDEBECK, Daniel P. DEVER, Joseph T. CLARK, Ann TSUKAMOTO, Nobuko UCHIDA
  • Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
    Publication number: 20110070641
    Abstract: Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating, and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided.
    Type: Application
    Filed: September 7, 2010
    Publication date: March 24, 2011
    Inventors: Nobuko Uchida, Ann Tsukamoto, Stanley Tamaki, Alexandra Capela, Tim Austin
  • Enriched Pancreatic Stem Cell and Progenitor Cell, Populations, and Methods For Identifying, Isolating and Enriching For Such Populations
    Publication number: 20100003749
    Abstract: Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating, and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided.
    Type: Application
    Filed: July 30, 2009
    Publication date: January 7, 2010
    Inventors: Nobuko Uchida, Ann Tsukamoto, Stanley Tamaki, Alexandra Capela, Tim Austin
  • Enriched Pancreatic Stem Cell and Progenitor Cell Populations, and Methods for Identifying, Isolating and Enriching for Such Populations
    Publication number: 20070212732
    Abstract: Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided.
    Type: Application
    Filed: August 27, 2004
    Publication date: September 13, 2007
    Inventors: Nobuko Uchida, Ann Tsukamoto, Stanley Tamaki, Alexandra Capela, Tim Austin
  • Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
    Publication number: 20060205072
    Abstract: Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided.
    Type: Application
    Filed: August 27, 2004
    Publication date: September 14, 2006
    Inventors: Nobuko Uchida, Ann Tsukamoto, Stanley Tamaki, Alexandra Capela, Tim Austin
  • Methods for gene transfer
    Patent number: 5928638
    Abstract: The present invention provides a method for optimizing gene transfer into hematopoietic stem cells (HSCs) by contacting the cells with hydroxyurea prior to gene transfer to induce HSCs in G0 into active cell cycle. This method is useful for treating patients suffering from a disease that is suitably treated by gene therapy or involves hematopoietic cells. A method is also provided for enhancing the efficacy of bone marrow transplantation by administering hydroxyurea to increase HSC yields.
    Type: Grant
    Filed: June 17, 1996
    Date of Patent: July 27, 1999
    Assignee: SyStemix, Inc.
    Inventors: Nobuko Uchida, Ann Tsukamoto, Irving Weissman
  • Human hematopoietic stem cell
    Patent number: 5914108
    Abstract: Human hematopoietic stem cells are provided by separation of the stem cells from dedicated cells. The stem cells may than be maintained by regeneration in an appropriate growth medium. Means are provided for assaying for the stem cells as to their capability for producing members of each of the hematopoietic lineages. A method for treating a human by implanting a cellular composition comprising greater than 90% human hematopoietic stem cells is also disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 22, 1999
    Assignee: Systemix, Inc.
    Inventors: Ann Tsukamoto, Charles M. Baum, Yukoh Aihara, Irving Weissman
  • Human hematopoietic stem cell
    Patent number: 5763197
    Abstract: Human hematopoietic stem cells are provided by separation of the stem cells from dedicated cells. The stem cells may than be maintained by regeneration in an appropriate growth medium. Means are provided for assaying for the stem cells as to their capability for producing members of each of the hematopoietic lineages.
    Type: Grant
    Filed: June 25, 1991
    Date of Patent: June 9, 1998
    Assignee: Systemix, Inc.
    Inventors: Ann Tsukamoto, Charles M. Baum, Yukoh Aihara, Irving Weissman
  • Human hematopoietic stem cell
    Patent number: 5750397
    Abstract: Human hematopoietic stem cells are provided by separation of the stem cells from dedicated cells. The stem cells may than be maintained by regeneration in an appropriate growth medium. Means are provided for assaying for the stem cells as to their capability for producing members of each of the hematopoietic lineages.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 12, 1998
    Assignee: Systemix, Inc.
    Inventors: Ann Tsukamoto, Charles M. Baum, Yukoh Aihara, Irving Weissman
  • Human hematopoietic stem cell
    Patent number: 5716827
    Abstract: Human hematopoietic stem cells are provided by separation of the stem cells from dedicated cells. The stem cells may than be maintained by regeneration in an appropriate growth medium. Means are provided for assaying for the stem cells as to their capability for producing members of each of the hematopoietic lineages.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 10, 1998
    Assignee: SyStemix, Inc.
    Inventors: Ann Tsukamoto, Charles M. Baum, Yukoh Aihara, Irving Weissman
  • Identification and isolation of human hematopoietic stem cells
    Patent number: 5643741
    Abstract: Human hematopoietic stem cells are identified according to expression of specific cell surface markers. Substantially homogenous stem cell compositions are obtained by selective isolation of cells free of markers associated with differentiated cells, while displaying epitopic characteristics associated with the stem cells. The stem cells may then be maintained by regeneration in an appropriate growth medium. Means are provided for assaying for the stem cells as to their capability for producing members of each of the hematopoietic lineages.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 1, 1997
    Assignee: Systemix, Inc.
    Inventors: Ann Tsukamoto, Charles M. Baum, Yukoh Aihara, Irving Weissman
  • Human hematopoietic stem cell
    Patent number: 5061620
    Abstract: Human hematopoietic stem cells are provided by separation of the stem cells from dedicated cells. The stem cells may than be maintained by regeneration in an appropriate growth medium. Means are provided for assaying for the stem cells as to their capability for producing members of each of the hematopoietic lineages.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: October 29, 1991
    Assignee: SyStemix, Inc.
    Inventors: Ann Tsukamoto, Charles M. Baum, Yukoh Aihara, Irving Weissman