Patents by Inventor Anna Gudny SIGURDARDOTTIR

Anna Gudny SIGURDARDOTTIR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIPARTITE SYSTEMS FOR PROTEIN DIMERIZATION AND METHODS OF USE
    Publication number: 20220380801
    Abstract: The disclosure provides compositions and methods that make use of a target protein that is capable of binding to a small molecule in order to form a complex, and a binding member that specifically binds to the complex, wherein the target protein is derived from a non-human protein and the small molecule is an inhibitor of the non-human protein. The non-human protein may be derived from a viral, bacterial, fungal or protozoal protein. These compositions and methods permit the controlled interaction of polypeptides that are individually fused to the target protein and binding member, respectively, and can be used to control the activity of dimerization-inducible proteins such as split transcription factors and split chimeric antigen receptors through the addition of the small molecule. The disclosure provides expression vectors, binding members, dimerization-inducible proteins, nucleic acids, cells, viral particles, kits, systems and methods that involve these components.
    Type: Application
    Filed: July 15, 2020
    Publication date: December 1, 2022
    Inventors: Lisa BAMBER, Roger Bradley DODD, Sandrine LEGG, Thomas Vincent MURRAY, David Gareth REES, Anna Gudny SIGURDARDOTTIR, Natalie Jo TIGUE, Lisa Marie Kitching VINALL, Christina SCHINDLER, Bruck TADDESE
  • METHODS FOR SELECTING PHOSPHATASE SELECTIVE AND NON-SELECTIVE PHOSPHATASE INHIBITORS
    Publication number: 20220313628
    Abstract: The present invention discloses a method to discover selective inhibitors of phosphatases.
    Type: Application
    Filed: May 24, 2022
    Publication date: October 6, 2022
    Applicant: United Kingdom Research and Innovation
    Inventors: Anne BERTOLOTTI, Indrajit DAS, Agnieszka KRZYZOSIAK, Adrien ROUSSEAU, Kim SCHNEIDER, Anna Gudny SIGURDARDOTTIR
  • Methods for selecting phosphatase selective and non-selective phosphatase inhibitors
    Patent number: 11364211
    Abstract: The present invention discloses a method to discover selective inhibitors of phosphatases.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: June 21, 2022
    Assignee: United Kingdom Research and Innovation
    Inventors: Anne Bertolotti, Indrajit Das, Agnieszka Krzyzosiak, Adrien Rousseau, Kim Schneider, Anna Gudny Sigurdardottir
  • Inhibitors and their uses
    Patent number: 11337941
    Abstract: The present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy, particularly in the treatment of a disease state alleviated by the inhibition of PPP1 R15A and PPP1 R15B, for example a disorder associated with accumulation of misfolded proteins or proteostatsis disorder. Compounds of the invention include compounds having the formula IA or a pharmaceutically acceptable salt thereof, wherein R1a, R3a, R5a, Xa and Ya are as defined herein.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: May 24, 2022
    Assignee: United Kingdom Research and Innovation
    Inventors: Anne Bertolotti, Indrajit Das, Agnieszka Krzyzosiak, Adrien Rousseau, Kim Schneider, Anna Gudny Sigurdardottir
  • Inhibitors and their uses
    Patent number: 11331286
    Abstract: The present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy, particularly in the treatment of a disease state alleviated by the inhibition of PPP1 R15A and PPP1 R15B, for example a disorder associated with accumulation of misfolded proteins or proteostatsis disorder. Compounds of the invention include compounds having the formula IA or a pharmaceutically acceptable salt thereof, wherein R1a, R3a, R5a, Xa and Ya are as defined herein.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: May 17, 2022
    Assignee: United Kingdom Research and Innovation
    Inventors: Anne Bertolotti, Indrajit Das, Agnieszka Krzyzosiak, Adrien Rousseau, Kim Schneider, Anna Gudny Sigurdardottir
  • Inhibitors and their uses
    Patent number: 11154519
    Abstract: The present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy, particularly in the treatment of a disease state alleviated by the inhibition of PPP1 R15A and PPP1 R15B, for example a disorder associated with accumulation of misfolded proteins or proteostatsis disorder. Compounds of the invention include compounds having the formula IA or a pharmaceutically acceptable salt thereof, wherein R1a, R3a, R5a, Xa and Ya are as defined herein.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: October 26, 2021
    Assignee: United Kingdom Research and Innovation
    Inventors: Anne Bertolotti, Indrajit Das, Agnieszka Krzyzosiak, Adrien Rousseau, Kim Schneider, Anna Gudny Sigurdardottir
  • INHIBITORS AND THEIR USES
    Publication number: 20200297668
    Abstract: The present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy, particularly in the treatment of a disease state alleviated by the inhibition of PPP1 R15A and PPP1 R15B, for example a disorder associated with accumulation of misfolded proteins or proteostatsis disorder. Compounds of the invention include compounds having the formula IA or a pharmaceutically acceptable salt thereof, wherein R1a, R3a, R5a, Xa and Ya are as defined herein.
    Type: Application
    Filed: February 28, 2020
    Publication date: September 24, 2020
    Applicant: Medical Research Council
    Inventors: Anne BERTOLOTTI, Indrajit DAS, Agnieszka KRZYZOSIAK, Adrien ROUSSEAU, Kim SCHNEIDER, Anna Gudny SIGURDARDOTTIR
  • INHIBITORS AND THEIR USES
    Publication number: 20200197337
    Abstract: The present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy, particularly in the treatment of a disease state alleviated by the inhibition of PPP1 R15A and PPP1 R15B, for example a disorder associated with accumulation of misfolded proteins or proteostatsis disorder. Compounds of the invention include compounds having the formula IA or a pharmaceutically acceptable salt thereof, wherein R1a, R3a, R5a, Xa and Ya are as defined herein.
    Type: Application
    Filed: February 28, 2020
    Publication date: June 25, 2020
    Applicant: Medical Research Council
    Inventors: Anne BERTOLOTTI, Indrajit DAS, Agnieszka KRZYZOSIAK, Adrien ROUSSEAU, Kim SCHNEIDER, Anna Gudny SIGURDARDOTTIR
  • METHODS FOR SELECTING PHOSPHATASE SELECTIVE AND NON-SELECTIVE PHOSPHATASE INHIBITORS
    Publication number: 20180125801
    Abstract: The present invention discloses a method to discover selective inhibitors of phosphatases.
    Type: Application
    Filed: April 8, 2016
    Publication date: May 10, 2018
    Applicant: MEDICAL RESEARCH COUNCIL
    Inventors: Anne BERTOLOTTI, Indrajit DAS, Agnieszka KRZYZOSIAK, Adrien ROUSSEAU, Kim SCHNEIDER, Anna Gudny SIGURDARDOTTIR