Abstract: Systems and methods for monitoring flow of cerebrospinal fluid through shunts are disclosed. A wireless, flexible flow sensor may comprise a substrate, a thermal actuation mechanism configured to supply thermal energy to a portion of a skin surface of the body, the portion of the skin surface overlaying a subdermal conduit for a body fluid, a temperature sensor configured to detect a change in a temperature related to the portion of the skin surface, a motion sensor supported by the substrate and configured to detect an orientation related to a segment of the subdermal conduit, and a microprocessor in wireless communication with a controller. The microprocessor may comprise circuitry configured to receive, from the controller, a first signal to activate the thermal actuation mechanism; and receive, from the temperature sensor, a second signal associated with the change in temperature related to the portion of the skin surface.