Patents by Inventor Anna Mallone

Anna Mallone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bioengineered in vitro 3D model of human atherosclerotic plaque
    Patent number: 11946071
    Abstract: The invention provides a method for the generation of a layered cellular 3 D microtissue aggregate, comprising the steps of contacting myeloid cells with a protein kinase C agonist, yielding primed myeloid cells; incubating the primed myeloid cells in the presence of LDL in a confined volume, particularly in a hanging drop culture; yielding a 3 D culture of myeloid cells; and incubating the 3 D culture together with fibroblasts in a hanging drop in the presence of LDL, yielding the layered cellular aggregate.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: April 2, 2024
    Assignee: UNIVERSITÄT ZÜRICH
    Inventors: Simon Hoerstrup, Benedikt Weber, Anna Mallone
  • BIOENGINEERED IN VITRO 3D MODEL OF HUMAN ATHEROSCLEROTIC PLAQUE
    Publication number: 20200325445
    Abstract: The invention provides a method for the generation of a layered cellular 3 D microtissue aggregate, comprising the steps of contacting myeloid cells with a protein kinase C agonist, yielding primed myeloid cells; incubating the primed myeloid cells in the presence of LDL in a confined volume, particularly in a hanging drop culture; yielding a 3 D culture of myeloid cells; and incubating the 3 D culture together with fibroblasts in a hanging drop in the presence of LDL, yielding the layered cellular aggregate.
    Type: Application
    Filed: August 23, 2018
    Publication date: October 15, 2020
    Inventors: Simon Hoerstrup, Benedikt Weber, Anna Mallone