Patents by Inventor Anna Nowicka

Anna Nowicka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted Pyrrolotriazines
    Publication number: 20240150362
    Abstract: The inventive compounds are small molecule therapeutics that are potent inhibitors of USP7 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease, disorder, or condition associated with USP7 activity.
    Type: Application
    Filed: August 25, 2023
    Publication date: May 9, 2024
    Inventors: Jacek Chrzanowski, Anna Gzik, Joanna Brzezinska, Robert Koralewski, Lukasz Joachimiak, Karolina Rozga, Szymon Kapuscinski, Bartlomiej Borek, Mateusz Urban, Sylwia Ciastek-Iskrzycka, Julita Nowicka, Kamil Lisiecki, Roman Blaszczyk, Adam Golebiowski, Jacek Olczak
  • 5?-phosphorothiolate mRNA 5?-end (cap) analogs, mRNA comprising the same, method of obtaining and uses thereof
    Patent number: 11066436
    Abstract: The present invention relates to nucleotides, analogs of mRNA 5?-end (cap) containing sulfur atom at the position 5? of 7-methylguanosine nucleoside. The disclosed compounds are recognized (bound and non-hydrolyzed) by DcpS enzyme (Decapping Scavenger), and thus may find therapeutic use as inhibitors thereof. DcpS is cap-specific enzyme with pyrophosphatase activity, which was identified as a therapeutic target in the treatment of spinal muscular atrophy (SMA). Some of the compounds disclosed have additional modifications in the phosphate chain, which modulate their affinity for DcpS enzyme.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: July 20, 2021
    Assignee: UNIWERSYTET WARSZAWSKI
    Inventors: Jacek Jemielity, Kaja Fac-Da̧browska, Blażej Wojtczak, Marek Baranowski, Anna Nowicka, Joanna Kowalska, Paweł Sikorski, Marcin Warmiński
  • 5'-Phosphorothiolate mRNA 5'-end (cap) Analogs, mRNA Comprising the Same, Method of Obtaining and Uses Thereof
    Publication number: 20190300563
    Abstract: The present invention relates to nucleotides, analogs of mRNA 5?-end (cap) containing sulfur atom at the position 5? of 7-methylguanosine nucleoside. The disclosed compounds are recognized (bound and non-hydrolyzed) by DcpS enzyme (Decapping Scavenger), and thus may find therapeutic use as inhibitors thereof. DcpS is cap-specific enzyme with pyrophosphatase activity, which was identified as a therapeutic target in the treatment of spinal muscular atrophy (SMA). Some of the compounds disclosed have additional modifications in the phosphate chain, which modulate their affinity for DcpS enzyme.
    Type: Application
    Filed: January 27, 2017
    Publication date: October 3, 2019
    Inventors: Jacek Jemielity, Kaja Fac-Dabrowska, Blazej Wojtczak, Marek Baranowski, Anna Nowicka, Joanna Kowalska, Pawel Sikorski, Marcin Warminski