Patents by Inventor Annabelle BISCANS

Annabelle BISCANS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONJUGATED OLIGONUCLEOTIDES
    Publication number: 20240084297
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
    Type: Application
    Filed: February 16, 2023
    Publication date: March 14, 2024
    Inventors: Anastasia KHVOROVA, Mehran NIKAN, Matthew HASSLER, Maire OSBORN, Reka HARASZTI, Andrew COLES, Anton TURANOV, Neil ARONIN, Annabelle BISCANS
  • OPTIMIZED ANTI-FLT1 OLIGONUCLEOTIDE COMPOUNDS FOR TREATMENT OF PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS
    Publication number: 20240067967
    Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
    Type: Application
    Filed: May 23, 2023
    Publication date: February 29, 2024
    Inventors: Anastasia Khvorova, Vignesh Narayan Hariharan, Sarah Davis, Annabelle Biscans, Ananth Karumanchi
  • Conjugated oligonucleotides
    Patent number: 11753638
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: September 12, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin, Annabelle Biscans
  • Optimized anti-FLT1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
    Patent number: 11702659
    Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
    Type: Grant
    Filed: June 22, 2022
    Date of Patent: July 18, 2023
    Assignees: UNIVERSITY OF MASSACHUSETTS, BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventors: Anastasia Khvorova, Vignesh Narayan Hariharan, Sarah Davis, Annabelle Biscans, Ananth Karumanchi
  • OPTIMIZED ANTI-FLT1 OLIGONUCLEOTIDE COMPOUNDS FOR TREATMENT OF PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS
    Publication number: 20230078622
    Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
    Type: Application
    Filed: June 22, 2022
    Publication date: March 16, 2023
    Inventors: Anastasia Khvorova, Vignesh Narayan Hariharan, Sarah Davis, Annabelle Biscans, Ananth Karumanchi
  • OLIGONUCLEOTIDES FOR SARS-CoV-2 MODULATION
    Publication number: 20230021431
    Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.
    Type: Application
    Filed: May 28, 2021
    Publication date: January 26, 2023
    Inventors: Anastasia Khvorova, Jonathan Watts, Zachary Kennedy, Annabelle Biscans, Bruno Miguel da Cruz Godinho, Chantal Ferguson, Dimas Echeverria Moreno, Ken Yamada, Daniel O'Reilly, Kathryn Monopoli, Vignesh Narayan Hariharan, Qi Tang, Sarah Davis, Samuel Hildebrand, Socheata Ly, Minwook Shin, Pranathi Meda Krishnamurthy, Nicholas McHugh, Jacquelyn Sousa, Jillian Caiazzi, Yann Thillier, Gitali Devi
  • CONJUGATED OLIGONUCLEOTIDES FOR TISSUE SPECIFIC DELIVERY
    Publication number: 20220042015
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution with enhanced in vivo silencing efficacy.
    Type: Application
    Filed: July 16, 2021
    Publication date: February 10, 2022
    Inventors: Anastasia Khvorova, Annabelle Biscans
  • BRANCHED LIPID CONJUGATES OF siRNA FOR SPECIFIC TISSUE DELIVERY
    Publication number: 20210108200
    Abstract: This disclosure relates to an siRNA-lipid conjugate of formula Y-L-(H)n. Y is an siRNA molecule, L is a linker covalently bonded to Y and H, each H is independently a hydrophobic chain comprising 5 to 50 carbon atoms, n is 1, 2, or 3, and linker L is bonded to the 3? end of the sense strand of the siRNA.
    Type: Application
    Filed: September 16, 2020
    Publication date: April 15, 2021
    Inventors: Anastasia Khvorova, Annabelle Biscans
  • CONJUGATED OLIGONUCLEOTIDES
    Publication number: 20190185855
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution.
    Type: Application
    Filed: August 11, 2017
    Publication date: June 20, 2019
    Inventors: Anastasia KHVOROVA, Mehran NIKAN, Matthew HASSLER, Maire OSBORN, Reka HARASZTI, Andrew COLES, Anton TURANOV, Neil ARONIN, Annabelle BISCANS