Patents by Inventor Anne J. Stone

Anne J. Stone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Kit for obtaining a digoxin concentrate from a serum sample
    Patent number: 4975248
    Abstract: Serum is passed through a column containing silica gel alkylated with lower alkyl groups. The column is then washed with dilute acid and water and the digoxin eluted with aqueous methanol at a volume less than about the volume of the serum to provide a digoxin concentrate that may be used in assay determinations. The invention also includes a kit comprising in a packaged combination for use in an assay for digoxin (a) a column containing silica gel alkylated with alkyl groups containing 1 to 2 carbon atoms and (b) an aqueous eluent solution which is 50%-70% by volume organic solvent. The organic solvent comprises from 1-4 carbon atoms and from 1-3 heteroatoms selected from the group consisting of oxygen and nitrogen.
    Type: Grant
    Filed: October 16, 1986
    Date of Patent: December 4, 1990
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Pyare Khanna, Roberta D. Ernst, Anne J. Stone
  • Serum pretreatment for digoxin assay
    Patent number: 4654311
    Abstract: Serum is passed through a column containing silica gel alkylated with lower alkyl groups. The column is then washed with diluted acid and water, and the digoxin eluted with aqueous methanol at a volume less than about the volume of the serum to provide a digoxin concentrate that may be used in assay determinations.
    Type: Grant
    Filed: June 15, 1984
    Date of Patent: March 31, 1987
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Pyare Khanna, Roberta D. Ernst, Anne J. Stone