Patents by Inventor Anne-Marie Light Mettus
Anne-Marie Light Mettus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100256051Abstract: A novel gene encoding a Coleopteran inhibitory Bacillus thuringiensis insecticidal crystal protein is disclosed. The protein, tIC851, is insecticidally active and provides plant protection from at least cotton boll weevil, Anthomomus grandis, when applied to plants in an insecticidally effective composition.Type: ApplicationFiled: April 5, 2007Publication date: October 7, 2010Inventors: Barbara Isaac, Elysia K. Krieger (f/k/a Joyce), Anne-Marie Light Mettus, Farhad Moshiri, Sakuntala Sivasupramanian
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Publication number: 20090087863Abstract: Disclosed is a novel Lepidopteran- and Coleopteran-active ?-endotoxin polypeptide, and compositions comprising the polypeptide, peptide fragments thereof, and antibodies specific therefor. Also disclosed are vectors, transformed host cells, and transgenic plants that comprise nucleic acid segments encoding the polypeptide. Also disclosed are methods of identifying related polypeptides and polynucleotides, methods of making and using transgenic cells comprising the novel sequences of the invention, as well as methods for controlling an insect population, such as the Western Corn Rootworm and Colorado potato beetle, and for conferring to a plant population resistance to the target insect species.Type: ApplicationFiled: September 29, 2008Publication date: April 2, 2009Inventors: Anne-Marie Light Mettus, James A. Baum
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Patent number: 7429454Abstract: Disclosed are novel DNA probes useful in detecting a nucleic acid sequence encoding a novel Lepidopteran- and Coleopteran-active ?-endotoxin polypeptide. Also disclosed are nucleic acid detection methods and kits involving the novel DNA probes.Type: GrantFiled: January 13, 2006Date of Patent: September 30, 2008Assignee: Monsanto Technology LLCInventors: Anne-Marie Light Mettus, James A. Baum
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Patent number: 7256017Abstract: Disclosed are novel synthetically-modified B. thuringiensis nucleic acid segments encoding ?-endotoxins having insecticidal activity against lepidopteran insects. Also disclosed are synthetic crystal proteins encoded by these novel nucleic acid sequences. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention. Also disclosed are methods for modifying, altering, and mutagenizing specific loop regions between the ? helices in domain 1 of these crystal proteins, including Cry1C, to produce genetically-engineered recombinant cry* genes, and the proteins they encode which have improved insecticidal activity. In preferred embodiments, novel Cry1C* amino acid segments and the modified cry1C* nucleic acid sequences which encode them are disclosed.Type: GrantFiled: November 29, 2004Date of Patent: August 14, 2007Assignee: Monsanto Technology LLCInventors: James A. Baum, Amy Jelen Gilmer, Anne-Marie Light Mettus
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Patent number: 7208656Abstract: A novel gene encoding a Coleopteran inhibitory Bacillus thuringiensis insecticidal crystal protein is disclosed. The protein, tIC851, is insecticidally active and provides plant protection from at least cotton boll weevil, Anthomomus grandis, when applied to plants in an insecticidally effective composition.Type: GrantFiled: December 13, 2005Date of Patent: April 24, 2007Assignee: Monsanto Technology LLCInventors: Barbara Isaac, Elysia K. Krieger, Anne-Marie Light Mettus, Farhad Moshiri, Sakuntala Sivasupramanian
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Patent number: 7022897Abstract: Disclosed are novel polynucleotides encoding Lepidopteran- and Coleopteran-active ?-endotoxin polypeptides and compositions comprising the polypeptides. Also disclosed are vectors, transformed host cells, and transgenic plants that comprise the novel nucleic acid segments encoding the ?-endotoxin polypeptides. Also disclosed are methods of identifying related polynucleotides encoding ?-endotoxin polypeptides, methods of making and using transgenic cells comprising the novel sequences of the invention, as well as methods for controlling an insect population, such as the Western Corn Rootworm and Colorado potato beetle, and for conferring to a plant population resistance to the target insect species.Type: GrantFiled: April 10, 2002Date of Patent: April 4, 2006Assignee: Monsanto Technology LLCInventors: Anne-Marie Light Mettus, James A. Baum
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Patent number: 6825006Abstract: Disclosed are novel synthetically-modified B. thuringiensis nucleic acid segments encoding &dgr;-endotoxins having insecticidal activity against lepidopteran insects. Also disclosed are synthetic crystal proteins encoded by these novel nucleic acid sequences. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention. Also disclosed are methods for modifying, altering, and mutagenizing specific loop regions between the &agr; helices in domain 1 of these crystal proteins, including Cry1C, to produce genetically-engineered recombinant cry* genes, and the proteins they encode which have improved insecticidal activity. In preferred embodiments, novel Cry1C* amino acid segments and the modified cry1C* nucleic acid sequences which encode them are disclosed.Type: GrantFiled: July 22, 2002Date of Patent: November 30, 2004Assignee: Monsanto Technology LLCInventors: James A. Baum, Amy Jelen Gilmer, Anne-Marie Light Mettus
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Publication number: 20040221334Abstract: Disclosed are novel synthetically-modified B. thuringiensis nucleic acid segments encoding &dgr;-endotoxins having insecticidal activity against lepidopteran insects. Also disclosed are synthetic crystal proteins encoded by these novel nucleic acid sequences. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention. Also disclosed are methods for modifying, altering, and mutagenizing specific loop regions between the &agr; helices in domain 1 of these crystal proteins, including Cry1C, to produce genetically-engineered recombinant cry* genes, and the proteins they encode which have improved insecticidal activity. In preferred embodiments, novel Cry1C* amino acid segments and the modified cry1C* nucleic acid sequences which encode them are disclosed.Type: ApplicationFiled: May 27, 2004Publication date: November 4, 2004Applicant: Monsanto Technology LLC.Inventors: James A. Baum, Amy Jelen Gilmer, Anne-Marie Light Mettus
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Patent number: 6809078Abstract: Disclosed are novel synthetically-modified B. thuringiensis nucleic acid segments encoding &dgr;-endotoxins having insecticidal activity against lepidopteran insects. Also disclosed are synthetic crystal proteins encoded by these novel nucleic acid sequences. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention. Also disclosed are methods for modifying, altering, and mutagenizing specific loop regions between the &agr; helices in domain 1 of these crystal proteins, including Cry1C, to produce genetically-engineered recombinant cry* genes, and the proteins they encode which have improved insecticidal activity. In preferred embodiments, novel Cry1C* amino acid segments and the modified cry1C* nucleic acid sequences which encode them are disclosed.Type: GrantFiled: October 5, 2001Date of Patent: October 26, 2004Assignee: Monsanto Technology LLCInventors: James A. Baum, Amy Jelen Gilmer, Anne-Marie Light Mettus
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Publication number: 20030229919Abstract: A novel gene encoding a Coleopteran inhibitory Bacillus thuringiensis insecticidal crystal protein is disclosed. The protein, tIC851, is insecticidally active and provides plant protection from at least cotton boll weevil, Anthomomus grandis, when applied to plants in an insecticidally effective composition.Type: ApplicationFiled: February 7, 2003Publication date: December 11, 2003Inventors: Barbara Isaac, Elysia K. Krieger (f/k/a Joyce), Anne-Marie Light Mettus, Farhad Moshiri, Sakuntala Sivasupramanian
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Publication number: 20030195336Abstract: Disclosed are novel synthetically-modified B. thuringiensis nucleic acid segments encoding &dgr;-endotoxins having insecticidal activity against lepidopteran insects. Also disclosed are synthetic crystal proteins encoded by these novel nucleic acid sequences. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention. Also disclosed are methods for modifying, altering, and mutagenizing specific loop regions between the &agr; helices in domain 1 of these crystal proteins, including Cry1C, to produce genetically-engineered recombinant cry* genes, and the proteins they encode which have improved insecticidal activity. In preferred embodiments, novel Cry1C* amino acid segments and the modified cry1C* nucleic acid sequences which encode them are disclosed.Type: ApplicationFiled: July 22, 2002Publication date: October 16, 2003Applicant: Monsanto Technology LLC.Inventors: James A. Baum, Amy Jelen Gilmer, Anne-Marie Light Mettus
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Publication number: 20030101482Abstract: Disclosed are novel synthetically-modified B. thuringiensis nucleic acid segments encoding &dgr;-endotoxins having insecticidal activity against lepidopteran insects. Also disclosed are synthetic crystal proteins encoded by these novel nucleic acid sequences. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention. Also disclosed are methods for modifying, altering, and mutagenizing specific loop regions between the &agr; helices in domain 1 of these crystal proteins, including Cry1C, to produce genetically-engineered recombinant cry* genes, and the proteins they encode which have improved insecticidal activity. In preferred embodiments, novel Cry1C* amino acid segments and the modified cry1C* nucleic acid sequences which encode them are disclosed.Type: ApplicationFiled: October 5, 2001Publication date: May 29, 2003Applicant: Monsanto Technology LLCInventors: James A. Baum, Amy Jelen Gilmer, Anne-Marie Light Mettus
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Publication number: 20030068335Abstract: Disclosed is a novel Lepidopteran- and Coleopteran-active &dgr;-endotoxin polypeptide, and compositions comprising the polypeptide, peptide fragments thereof, and antibodies specific therefor. Also disclosed are vectors, transformed host cells, and transgenic plants that comprise nucleic acid segments encoding the polypeptide. Also disclosed are methods of identifying related polypeptides and polynucleotides, methods of making and using transgenic cells comprising the novel sequences of the invention, as well as methods for controlling an insect population, such as the Western Corn Rootworm and Colorado potato beetle, and for conferring to a plant population resistance to the target insect species.Type: ApplicationFiled: April 10, 2002Publication date: April 10, 2003Applicant: Monsanto Technology LLC.Inventors: Anne-Marie Light Mettus, James A. Baum
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Patent number: 6541448Abstract: A novel gene encoding a Coleopteran inhibitory Bacillus thuringiensis insecticidal crystal protein is disclosed. The protein, tIC851, is insecticidally active and provides plant protection from at least cotton boll weevil, Anthomomus grandis, when applied to plants in an insecticidally effective composition.Type: GrantFiled: May 11, 2001Date of Patent: April 1, 2003Assignee: Monsanto Technology LLCInventors: Barbara Isaac, Elysia K. Krieger, Anne-Marie Light Mettus, Farhad Moshiri, Sakuntala Sivasupramanian
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Patent number: 6468523Abstract: Disclosed is a novel Lepidopteran- and Coleopteran-active &dgr;-endotoxin polypeptide, and compositions comprising the polypeptide, peptide fragments thereof, and antibodies specific therefor. Also disclosed are vectors, transformed host cells, and transgenic plants that comprise nucleic acid segments encoding the polypeptide. Also disclosed are methods of identifying related polypeptides and polynucleotides, methods of making and using transgenic cells comprising the novel sequences of the invention, as well as methods for controlling an insect population, such as the Western Corn Rootworm and Colorado potato beetle, and for conferring to a plant population resistance to the target insect species.Type: GrantFiled: November 2, 1998Date of Patent: October 22, 2002Assignee: Monsanto Technology LLCInventors: Anne-Marie Light Mettus, James A. Baum
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Publication number: 20020103362Abstract: A novel gene encoding a Coleopteran inhibitory Bacillus thuringiensis insecticidal crystal protein is disclosed. The protein, tIC851, is insecticidally active and provides plant protection from at least cotton boll weevil, Anthomomus grandis, when applied to plants in an insecticidally effective composition.Type: ApplicationFiled: May 11, 2001Publication date: August 1, 2002Inventors: Barbara Isaac, Elysia K. Krieger (f/k/a Joyce), Anne-Marie Light Mettus, Farhad Moshiri, Sakuntala Sivasupramanian
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Patent number: 6423828Abstract: Disclosed are novel synthetically-modified B. thuringiensis nucleic acid segments encoding &dgr;-endotoxins having insecticidal activity against lepidopteran insects. Also disclosed are synthetic crystal proteins encoded by these novel nucleic acid sequences. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention. Also disclosed are methods for modifying, altering, and mutagenizing specific loop regions between the &agr; helices in domain 1 of these crystal proteins, including Cry1C, to produce genetically-engineered recombinant cry* genes, and the proteins they encode which have improved insecticidal activity. In preferred embodiments, novel Cry1C* amino acid segments and the modified cry1C* nucleic acid sequences which encode them are disclosed.Type: GrantFiled: June 22, 1999Date of Patent: July 23, 2002Assignee: Monsanto Technology LLCInventors: James A. Baum, Amy Jelen Gilmer, Anne-Marie Light Mettus
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Patent number: 6313378Abstract: Disclosed are novel synthetically-modified B. thuringiensis nucleic acid segments encoding &dgr;-endotoxins having insecticidal activity against lepidopteran insects. Also disclosed are synthetic crystal proteins encoded by these novel nucleic acid sequences. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention. Also disclosed are methods for modifying, altering, and mutagenizing specific loop regions between the &agr; helices in domain 1 of these crystal proteins, including Cry1C, to produce genetically-engineered recombinant cry* genes, and the proteins they encode which have improved insecticidal activity. In preferred embodiments, novel Cry1C* amino acid segments and the modified cry1C* nucleic acid sequences which encode them are disclosed.Type: GrantFiled: June 21, 1999Date of Patent: November 6, 2001Assignee: Monsanto Technology LLCInventors: James A. Baum, Amy Jelen Gilmer, Anne-Marie Light Mettus
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Patent number: 6153814Abstract: Disclosed are novel synthetically-modified B. thuringiensis nucleic acid segments encoding .delta.-endotoxins having insecticidal activity against lepidopteran insects. Also disclosed are synthetic crystal proteins encoded by these novel nucleic acid sequences. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention. Also disclosed are methods for modifying, altering, and mutagenizing specific loop regions between the .alpha. helices in domain 1 of these crystal proteins, including Cry1C, to produce genetically-engineered recombinant cry* genes, and the proteins they encode which have improved insecticidal activity. In preferred embodiments, novel Cry1C* amino acid segments and the modified cry1C* nucleic acid sequences which encode them are disclosed.Type: GrantFiled: February 17, 1999Date of Patent: November 28, 2000Assignee: Monsanto CompanyInventors: James A. Baum, Amy Jelen Gilmer, Anne-Marie Light Mettus
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Patent number: 5942664Abstract: Disclosed are novel synthetically-modified B. thuringiensis nucleic acid segments encoding .delta.-endotoxins having insecticidal activity against lepidopteran insects. Also disclosed are synthetic crystal proteins encoded by these novel nucleic acid sequences. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention. Also disclosed are methods for modifying, altering, and mutagenizing specific loop regions between the .alpha. helices in domain 1 of these crystal proteins, including Cry1C, to produce genetically-engineered recombinant cry* genes, and the proteins they encode which have improved insecticidal activity. In preferred embodiments, novel Cry1C* amino acid segments and the modified cry1C* nucleic acid sequences which encode them are disclosed.Type: GrantFiled: November 27, 1996Date of Patent: August 24, 1999Assignee: Ecogen, Inc.Inventors: James A. Baum, Amy Jelen Gilmer, Anne-Marie Light Mettus