Abstract: The invention relates to therapeutic compositions comprising at least one isolated bacterium and a pharmaceutically acceptable excipient, as well as methods of preparing such therapeutic compositions. The therapeutic compositions find application in the treatment of dysbiosis, in particular dysbiosis of the gastrointestinal tract.

Abstract: The disclosure relates to therapeutic compositions comprising isolated bacteria useful in the treatment of ulcerative colitis or Crohn's disease. Related methods and uses are also disclosed.

Abstract: Methods and agents for modulating intracellular coenzyme A levels are described for therapeutic purposes. Increasing intracellular coenzyme A increases alternate macrophage activation resulting in suppression or resolution of an immune response for benefit in treating inflammatory diseases. Decreasing intracellular coenzyme A levels decreases alternate macrophage activation which is beneficial in treating NASH/NAFLD and various fibrotic diseases as well as reversing immune suppressing activity of tumor-associated immune cells such as macrophages for the treatment of cancer.

Abstract: The invention relates to therapeutic compositions comprising at least one isolated bacterium and a pharmaceutically acceptable excipient, as well as methods of preparing such therapeutic compositions. The therapeutic compositions find application in the treatment of dysbiosis, in particular dysbiosis of the gastrointestinal tract.

Abstract: Lubricant composition comprising: at least one base oil; and 0.1 to 30% by weight of an imidazoline compound of formula (A): defined such that: R1 represents a linear or branched alkyl or alkenyl group comprising 1 to 16 carbon atoms, optionally substituted at the end of the chain by a group selected from among NH2, OH or SH; and R2 represents a linear or branched alkyl or alkenyl group comprising 1 to 36 carbon atoms.

Abstract: A lubricant composition comprising: at least one base oil; and from 0.1% to 30% by weight of a phosphorus ester compound of formula (A): in which s is 0 or 1; and the radicals X represent, independently of each other, —OR? or R? moieties, where R? represents hydrogen or a linear or branched hydrocarbon moiety, preferably having from 1 to 36 carbon atoms, with the proviso that: when s is 0, the three X radicals represent —OR? moieties, and when s is 1, at least two of the three X radicals are —OR? moieties.

Abstract: The invention relates to bacterial compositions for the treatment or prevention thereof of a disease, in particular an infectious disease such as C. difficile infection.

Abstract: The invention relates to therapeutic compositions comprising at least one isolated bacterium and a pharmaceutically acceptable excipient, as well as methods of preparing such therapeutic compositions. The therapeutic compositions find application in the treatment of dysbiosis, in particular dysbiosis of the gastrointestinal tract.

Abstract: We describe a method and apparatus for analysing a sample. The method may comprise extracting a plurality of sequence reads from within the sample. Genomic analysis is then performed on the plurality of sequence reads by comparing the plurality of sequence reads to reference genomes stored in a reference database, wherein each stored reference genome comprises a set of reference sequences. Before performing the genomic analysis, the method further comprises comparing screening sequences with at least one of the set of reference sequences and the plurality of sequence reads from the sample. When it is determined that a screening sequence matches at least one sequence within either the set of reference sequences or the plurality of sequence reads, the at least one matching sequence is masked.

Abstract: Methods and agents for modulating intracellular coenzyme A levels are described for therapeutic purposes. Increasing intracellular coenzyme A increases alternate macrophage activation resulting in suppression or resolution of an immune response for benefit in treating inflammatory diseases. Decreasing intracellular coenzyme A levels decreases alternate macrophage activation which is beneficial in treating NASH/NAFLD and various fibrotic diseases as well as reversing immune suppressing activity of tumor-associated immune cells such as macrophages for the treatment of cancer.

Abstract: A method of inhibiting scale in a geological formation comprising depositing a binder on the formation surface, delivering a nano-material to the surface where it chemically interacts with the binder, emplacing a scale inhibitor on the formation that is absorbed by the nano-material, where a sustained release of the scale inhibitor into the geological formation results.

Abstract: The present invention relates to a method of inhibiting scale in a geological formation such as a hydrocarbon reservoir and a kit of parts for performing the method.

Abstract: The invention provides a retraction device (1) adapted for use in minimally invasive surgery, said device comprising: (a) access means (3); (b) rigid support means; (c) expandable retraction means (2) comprising a multiplicity of radially oriented members (10); (d) flexible attachment means (6); and (e) a multiplicity of magnetic means, wherein said expandable retraction means in its non-expanded form is attached to said rigid support means by said flexible attachment means and is insertable into a subject through said access means, and wherein said multiplicity of magnetic means are comprised in said expandable retraction means.

Abstract: An electrochemical sensor apparatus and method for measuring scale, such as mineral scale or other particulates, which deposit on the surface of pipelines or process equipment. The device has an electrochemical cell with a working electrode and fluid flow control means positioned so as to release a fluid jet onto the working electrode. The velocity of the fluid jet is controllable and is defined by the Reynolds number of the fluid when the fluid is in the fluid flow control means. Measurement of the electrical output from the electrochemical cell and the Reynolds number provide a measure of the build-up of scale on the working electrode.