Abstract: The present invention provides an in vitro method for detecting immunosuppressive fibroblasts, in particular Cancer Associated Fibroblast (CAFs) in a cancer sample from a subject suffering from cancer, wherein the method comprises detecting ANTXR1+ fibroblasts in the cancer sample from said patient. The invention also concerns an in vitro method for predicting a response of a subject suffering from cancer to an immunotherapy treatment, an immunotherapy treatment for use in the treatment of a cancer in a patient, the use of ANTXR1 as a biomarker for the identification of immunosuppressive fibroblasts, in particular immunosuppressive CAFs, an agent targeting ANTXR1+ fibroblasts for use in the treatment of a cancer in a patient, and a product or kit comprising a) an agent targeting ANTXR1+ fibroblasts and b) an immunotherapy treatment.

Abstract: The present invention provides an in vitro method for selecting a patient affected with a tumor for an immunotherapy treatment or for predicting the response of a subject affected with a tumor to an immunotherapy treatment, wherein the method comprises: (a) detecting DPP4+ CAFs (Cancer Associated Fibroblast), and/or CD73+ CAFs, and/or B7H3+ CAFs, and/or OX40L+ CAFs, and/or JAM2+ CAFs in a cancer sample from said patient; (b) determining the level(s) of DPP4+ CAFs, and/or CD73+ CAFs, and/or B7H3+ CAFs, and/or OX40L+ CAFs, and/or JAM2+ CAFs in said cancer sample, wherein the responsiveness of said patient to an immunotherapy treatment is inversely proportional to the level(s) of DPP4+ CAFs, and/or CD73+ CAFs, and/or B7H3+ CAFs, and/or OX40L+ CAFs, and/or JAM2+ CAFs in the cancer sample; (c) optionally, selecting patients with low level(s) of DPP4+ CAFs, and/or CD73+ CAFs, and/or B7H3+ CAFs, and/or OX40L+ CAFs, and/or JAM2+ CAFs as suitable for an immunotherapy treatment.

Abstract: The present invention relates to new methods of treatment of cancer, in particular of breast cancer, and methods of screening of compounds useful in the treatment of cancer. The present invention further provides new prognostic and/or diagnostic markers in human cancer.

Abstract: Firing device includes a firearm which includes a cartridge carrier in the loader in front of the entry of the barrel and supported against a supporting element of the casing which includes the firing mechanism and whereby the barrel slides in the casing into a position in which the barrel comes to a stop through the action of a return spring against the front part of the case of the cartridges and wherein each cartridge is provided with propulsion arrangement to project the case and the barrel forward.

Abstract: A flexible tubular hose, in particular for transporting fluids under pressure, comprising pressure-resistant armoring constituted by winding at least one pair of interlockable metal section wires, one of which has a T-section and the other of which has a U-section, the ribs of the T-section wire being directed toward the outside of the flexible tubular hose and the ribs of the U-section wire being directed toward the axis of the flexible tubular hose.