Abstract: The present invention relates to an arrangement for collection and separation of a body fluid, e.g. whole blood, for purposes of analysis of a component, e.g. plasma, of a sample of the body fluid. It comprises means for receiving a body fluid, a filter arrangement (50) comprising a separation filter arrangement for separation of the component(s) to be analysed and a detection filter in communication with the separation filter arrangement. The filter arrangement comprises a pre-filter (6) having a filter volume adapted to be capable to receive a volume of body fluid exceeding a volume of a sample to be analysed, which comprises a first portion defining a sample zone volume arranged to form a sample zone and at least one second portion defining an excess removal zone volume, forming an excess fluid removal zone the volume of which exceeds said sample zone volume.

Abstract: The present invention relates to an arrangement for collection and separation of a body fluid, e.g. whole blood, for purposes of analysis of a component, e.g. plasma, of a sample of the body fluid. It comprises means for receiving a body fluid, a filter arrangement (50) comprising a separation filter arrangement for separation of the component(s) to be analysed and a detection filter in communication with the separation filter arrangement. The filter arrangement comprises a pre-filter (6) having a filter volume adapted to be capable to receive a volume of body fluid exceeding a volume of a sample to be analysed, which comprises a first portion defining a sample zone volume arranged to form a sample zone and at least one second portion defining an excess removal zone volume, forming an excess fluid removal zone the volume of which exceeds said sample zone volume.