Patents by Inventor Annemieke Madder
Annemieke Madder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230382947Abstract: The present invention relates to a method for covalently binding a first agent and a second agent, the first agent comprising a first recognition element, wherein the first recognition element comprises an 1,4-dioxo moiety having a structure of Formula IA, IB or IC, wherein R12 is C1-30alkyl, C2-30alkenyl, C6-15aryl, or C5-15heteroaryl, wherein the C1-30alkyl, C2-30alkenyl, C6-15aryl, or C5-15heteroaryl group are optionally substituted with an C1-6alkyl, C3-6cycloalkyl, halogen, amine, hydroxyl, sulfhydryl, carboxyl, or C1-6alkoxy; and R13, if present, is hydrogen, C1-30alkyl or C2-30alkenyl; the second agent comprising a second recognition element, wherein the second recognition element comprises a nucleophilic moiety selected from a hydrazine moiety, an aminooxy moiety, an aminosulfanyl moiety or a hydroxylamine moiety; wherein: (A) the first recognition element and the second recognition element are capable of non-covalently binding to each other such that the 1,4-dioxo moiety and the nucleophilic moiety aType: ApplicationFiled: October 13, 2021Publication date: November 30, 2023Applicant: UNIVERSITEIT GENTInventors: Alex MANICARDI, Annemieke MADDER
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Patent number: 11608326Abstract: The present invention relates to synthetic receptors for ionophoric compounds, such as ionophoric toxins. Hence, the invention provides synthetic molecules capable of binding different ionophoric compounds, thereby being suitable for use in the detection, isolation and detoxification of such ionophoric compounds. The present invention further provides the use of such synthetic receptors in human and veterinary medicine, such as in the diagnosis, prevention and/or treatment of disorders caused by such ionophoric compounds. Finally, the invention provides methods of preparing such synthetic receptors for ionophoric compounds.Type: GrantFiled: February 27, 2019Date of Patent: March 21, 2023Assignee: Universiteit GentInventors: Vincent Ornelis, Annemieke Madder, Sarah de Saeger, Andreja Rajkovic, Benedikt Sas
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Patent number: 11397186Abstract: The present invention relates to a method for covalently binding a cell surface protein and a ligand, the ligand being capable of specifically binding to the cell surface protein, the method consisting essentially of contacting the living cells expressing the cell surface protein with the ligand comprising at least one furan moiety, thereby covalently binding the cell surface protein and the ligand.Type: GrantFiled: June 30, 2020Date of Patent: July 26, 2022Assignee: UNIVERSITEIT GENTInventors: Annemieke Madder, Christophe Ampe, Willem Vannecke, Marleen Van Troys
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Publication number: 20220169604Abstract: The present invention in general relates to the field of bioconjugation. More in particular, the invention relates to novel bioconjugation reactants based on an ?,? unsaturated ?-hydroxylactam structure, amongst others allowing a higher degree of functionalization compared to classical bioconjugation reactants such as maleimide. The present invention also provides methods of preparing the novel bioconjugation reactants, as well as uses thereof in human and/or veterinary medicine; and conjugation processes.Type: ApplicationFiled: February 28, 2020Publication date: June 2, 2022Applicant: Universiteit GentInventors: Annemieke Madder, Ewout De Geyter, Eirini Antonatou, Sabina Smolen, Dimitris Kalaitzakis, Georgios Vassilikogiannakis
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Patent number: 11053279Abstract: The present invention relates to a method for site-selective coupling of a first agent to a second agent, comprising the steps of: contacting a first agent comprising at least one furan moiety with an activation signal and with a second agent comprising at least one hydrazine moiety or at least one hydroxylamine moiety, thereby activating said furan moiety to an activated furan moiety; and reacting said activated furan moiety with the hydrazine moiety or the hydroxylamine moiety, thereby site-selectively coupling said first agent to said second agent.Type: GrantFiled: June 16, 2016Date of Patent: July 6, 2021Assignee: UNIVERSITEIT GENTInventors: Annemieke Madder, Eirini Antonatou, Kurt Hoogewijs
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Publication number: 20210018512Abstract: The present invention relates to a method for covalently binding a cell surface protein and a ligand, the ligand being capable of specifically binding to the cell surface protein, the method consisting essentially of contacting the living cells expressing the cell surface protein with the ligand comprising at least one furan moiety, thereby covalently binding the cell surface protein and the ligand.Type: ApplicationFiled: June 30, 2020Publication date: January 21, 2021Inventors: Annemieke MADDER, Christophe AMPE, Willem VANNECKE, Marleen VAN TROYS
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Publication number: 20210009569Abstract: The present invention relates to synthetic receptors for ionophoric compounds, such as ionophoric toxins. Hence, the invention provides synthetic molecules capable of binding different ionophoric compounds, thereby being suitable for use in the detection, isolation and detoxification of such ionophoric compounds. The present invention further provides the use of such synthetic receptors in human and veterinary medicine, such as in the diagnosis, prevention and/or treatment of disorders caused by such ionophoric compounds. Finally, the invention provides methods of preparing such synthetic receptors for ionophoric compounds.Type: ApplicationFiled: February 27, 2019Publication date: January 14, 2021Inventors: Vincent Ornelis, Annemieke Madder, Sarah de Saeger, Andreja Rajkovic, Benedikt Sas
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Patent number: 10753944Abstract: The present invention relates to a method for covalently binding a cell surface protein and a ligand, the ligand being capable of specifically binding to the cell surface protein, the method consisting essentially of contacting the living cells expressing the cell surface protein with the ligand comprising at least one furan moiety, thereby covalently binding the cell surface protein and the ligand.Type: GrantFiled: March 1, 2017Date of Patent: August 25, 2020Assignee: UNIVERSITEIT GENTInventors: Annemieke Madder, Christophe Ampe, Willem Vannecke, Marleen Van Troys
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Publication number: 20200246472Abstract: The present invention provides peptide hydrogelators capable of forming hydrogels as carriers of active ingredients and acting as sustained or controlled release drug delivery systems.Type: ApplicationFiled: February 16, 2017Publication date: August 6, 2020Inventors: Charlotte Martin, Annemieke Madder, Steven Ballet, Richard Hoogenboom
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Patent number: 10526371Abstract: Provided are hydrogel-forming peptides that comprise at least one dyad of hydrophobic amino acid residues in which one is a ?3- or ?2-homo amino acid residue. The hydrogels derived from these peptides can be loaded with biological materials and can be used in physiological conditions.Type: GrantFiled: July 13, 2016Date of Patent: January 7, 2020Assignees: Universiteit Gent, Vrije Universiteit BrusselInventors: Richard Hoogenboom, Annemieke Madder, Steven Ballet
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Publication number: 20190064176Abstract: The present invention relates to a method for covalently binding a cell surface protein and a ligand, the ligand being capable of specifically binding to the cell surface protein, the method consisting essentially of contacting the living cells expressing the cell surface protein with the ligand comprising at least one furan moiety, thereby covalently binding the cell surface protein and the ligand.Type: ApplicationFiled: March 1, 2017Publication date: February 28, 2019Inventors: Annemieke MADDER, Christophe AMPE, Willem VANNECKE, Marleen VAN TROYS
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Publication number: 20190002494Abstract: The present invention relates to a method for site-selective coupling of a first agent to a second agent, comprising the steps of: contacting a first agent comprising at least one furan moiety with an activation signal and with a second agent comprising at least one hydrazine moiety or at least one hydroxylamine moiety, thereby activating said furan moiety to an activated furan moiety; and reacting said activated furan moiety with the hydrazine moiety or the hydroxylamine moiety, thereby site-selectively coupling said first agent to said second agent.Type: ApplicationFiled: June 16, 2016Publication date: January 3, 2019Applicant: UNIVERSITEIT GENTInventors: Annemieke Madder, Eirini Antoatou, Kurt Hoogewijs
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Publication number: 20180201648Abstract: Provided are hydrogel-forming peptides that comprise at least one dyad of hydrophobic amino acid residues in which one is a ?3- or ?2-homo amino acid residue. The hydrogels derived from these peptides can be loaded with biological materials and can be used in physiological conditions.Type: ApplicationFiled: July 13, 2016Publication date: July 19, 2018Inventors: Richard Hoogenboom, Annemieke Madder, Steven Ballet
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Patent number: 9708363Abstract: The present invention relates to a method for cross-linking peptides using an activated furan-moiety. In particular, the present invention provides a method for cross-linking peptides comprising the steps of: a) providing a composition comprising furan-peptides, said furan-peptides comprising at least one amino acid comprising a furan-moiety; b) contacting said composition comprising furan-peptides with second peptides, thereby obtaining a mixture comprising furan-peptides and second peptides; c) adding an activation signal to said mixture of step b), thereby activating said furan-peptides to activated furan-peptides, and d) reacting said activated furan-peptides with said second peptides, thereby cross-linking said activated furan-peptides with said second peptides.Type: GrantFiled: January 25, 2016Date of Patent: July 18, 2017Assignee: UNIVERSITEIT GENTInventors: Annemieke Madder, Kurt Hoogewijs, Annelies Deceuninck, Lieselot Carrette
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Publication number: 20160244481Abstract: The present invention relates to a method for cross-linking peptides using an activated furan-moiety. In particular, the present invention provides a method for cross-linking peptides comprising the steps of: a) providing a composition comprising furan-peptides, said furan-peptides comprising at least one amino acid comprising a furan-moiety; b) contacting said composition comprising furan-peptides with second peptides, thereby obtaining a mixture comprising furan-peptides and second peptides; c) adding an activation signal to said mixture of step b), thereby activating said furan-peptides to activated furan-peptides, and d) reacting said activated furan-peptides with said second peptides, thereby cross-linking said activated furan-peptides with said second peptides.Type: ApplicationFiled: January 25, 2016Publication date: August 25, 2016Inventors: Annemieke Madder, Kurt Hoogewijs, Annelies Deceuninck, Lieselot Carrette
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Patent number: 9290537Abstract: The present invention relates to a method for cross-linking peptides using an activated furan-moiety. In particular, the present invention provides a method for cross-linking peptides comprising the steps of: a) providing a composition comprising furan-peptides, said furan-peptides comprising at least one amino acid comprising a furan-moiety; b) contacting said composition comprising furan-peptides with second peptides, thereby obtaining a mixture comprising furan-peptides and second peptides; c) adding an activation signal to said mixture of step b), thereby activating said furan-peptides to activated furan-peptides, and d) reacting said activated furan-peptides with said second peptides, thereby cross-linking said activated furan-peptides with said second peptides.Type: GrantFiled: December 23, 2011Date of Patent: March 22, 2016Assignee: UNIVERSITEIT GENTInventors: Annemieke Madder, Kurt Hoogewijs, Annelies Deceuninck, Lieselot Carrette