Patents by Inventor Annette Grave
Annette Grave has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240156741Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.Type: ApplicationFiled: January 24, 2024Publication date: May 16, 2024Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, JIA-NING XIANG, WILLIAM W. XIANG, JAMES TIEN, STEFANIE THIEL, NORBERT POLLINGER, ANNETTE GRAVE
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Publication number: 20240148758Abstract: The invention relates to a product for the release of highly lipophilic physiologically active substances, comprising a core and a coating on top of the core, the coating comprising one or more highly lipophilic physiologically active substances, one or more water-soluble film-forming agents and, relative to the weight of all components, not more than 20 wt % of other auxiliary substances.Type: ApplicationFiled: October 16, 2020Publication date: May 9, 2024Applicant: ADD Advanced Drug Delivery Technologies Ltd.Inventors: Mirko Nowak, Jay Nowak, Annette Grave, Monika Wentzlaff, Sarah Barthold, Christian Geugelin
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Publication number: 20240139215Abstract: The invention relates to a solid dosage form that comprises a matrix with one or more highly lipophilic physiologically active substances, one or more water-soluble binders and, relative to the weight of all components, not more than 20 wt % of other auxiliary substances, wherein a physiologically active substance being highly lipophilic if it has a log P of 4 or more.Type: ApplicationFiled: October 16, 2020Publication date: May 2, 2024Applicant: ADD Advanced Drug Delivery Technologies Ltd.Inventors: Mirko Nowak, Jay Jesko Nowak, Annette Grave, Monika Wentzlaff, Sarah Barthold, Christian Geugelin
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Patent number: 11925710Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.Type: GrantFiled: June 17, 2022Date of Patent: March 12, 2024Assignee: XWPHARMA LTD.Inventors: Sami Karaborni, Daniel M. Canafax, Jia-Ning Xiang, William W. Xiang, James Tien, Stefanie Thiel, Norbert Pollinger, Annette Grave
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Publication number: 20220323361Abstract: A process for the continuous production of an active ingredient granulate is provided, which comprises the following steps: (a) preparing a spray composition by dissolving or dispersing an active ingredient and optionally one or more excipients in a liquid; (b) providing solid particles in a process space; (c) introducing droplets of the spray composition into an injection zone of the process space in which the liquid evaporates; (d) repeated guiding of the solid particles past the sprayed droplets in the process space with the aid of a process gas jet, so that at least a portion of the droplets, which may have already lost part of the liquid contained, comes into contact with solid particles and larger solid particles are formed through agglomeration; (e) removing the active ingredient granulate from the process space in the form of solid particles, wherein the active ingredient comprises metformin or an acid addition salt of metformin, in particular metformin hydrochloride.Type: ApplicationFiled: April 9, 2020Publication date: October 13, 2022Applicant: ADD Advanced Drug Delivery Technologies Ltd.Inventors: Reinhard NOWAK, Norbert PÖLLINGER, Annette GRAVE, Michael JACOB
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Publication number: 20220323365Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.Type: ApplicationFiled: June 17, 2022Publication date: October 13, 2022Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, JIA-NING XIANG, WILLIAM W. XIANG, JAMES TIEN, STEFANIE THIEL, NORBERT POLLINGER, ANNETTE GRAVE
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Publication number: 20220280432Abstract: A method for the continuous production of an active ingredient granulate is provided, which comprises the following steps: (a) preparing a spray composition by dissolving or dispersing an active ingredient and optionally one or more excipients in a liquid; (b) providing solid particles in a process space; (c) introducing droplets of the spray composition into an injection zone of the process space in which the liquid evaporates; (d) repeatedly guiding the solid particles back past the sprayed droplets in the process space with the aid of a process gas jet, so that at least a portion of the droplets, which may have already lost part of the liquid contained, comes into contact with solid particles and larger solid particles are formed through agglomeration; (e) removing the active ingredient granulate from the process space in the form of solid particles, wherein the active ingredient in the form used has a Hausner factor of 1.19 or greater.Type: ApplicationFiled: April 9, 2020Publication date: September 8, 2022Applicant: ADD Advanced Drug Delivery Technologies Ltd.Inventors: Reinhard NOWAK, Norbert PÖLLINGER, Annette GRAVE, Michael JACOB
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Patent number: 11395801Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.Type: GrantFiled: October 5, 2021Date of Patent: July 26, 2022Assignee: XWPHARMA LTD.Inventors: Sami Karaborni, Daniel M. Canafax, Jia-Ning Xiang, William W. Xiang, James Tien, Stefanie Thiel, Norbert Pollinger, Annette Grave
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Publication number: 20220105044Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.Type: ApplicationFiled: October 5, 2021Publication date: April 7, 2022Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, JIA-NING XIANG, WILLIAM W. XIANG, JAMES TIEN, STEFANIE THIEL, NORBERT POLLINGER, ANNETTE GRAVE
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Publication number: 20180369151Abstract: The invention relates to an oral pharmaceutical dosage form comprising a plurality of coated particles, wherein said coated particles comprise a core which comprises a Tapentadol component and which is coated with a controlled release coating material, wherein the controlled release coating material comprises a lubricant component and a polymer component, wherein the polymer component comprises one or more cellulose ethers and/or one or more acrylates, and wherein the pharmaceutical dosage form provides controlled release of the Tapentadol component.Type: ApplicationFiled: May 29, 2018Publication date: December 27, 2018Applicant: GRÜNENTHAL GMBHInventors: Marc SCHILLER, Ulrich REINHOLD, Ulrike BERTRAM, Wolfgang PRANGE, Anika-Anina PHILIPP, Stefanie STRAUB, Annette GRAVE, Norbert POELLINGER
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Patent number: 9649280Abstract: The disclosure relates to pharmaceutical compositions useful in the treatment of adrenal insufficiency in paediatric or elderly subjects.Type: GrantFiled: May 12, 2014Date of Patent: May 16, 2017Assignee: Diurnal LimitedInventors: Hiep Huatan, Richard Ross, Martin Whitaker, Norbert Poellinger, Annette Grave
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Publication number: 20160081942Abstract: The disclosure relates to pharmaceutical compositions useful in the treatment of adrenal insufficiency in paediatric or elderly subjects.Type: ApplicationFiled: May 12, 2014Publication date: March 24, 2016Applicant: Diurnal LimitedInventors: Hiep Huatan, Richard Ross, Martin Whitaker, Norbert Poellinger, Annette Grave
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Patent number: 9289390Abstract: Taste masked multi-layered particles include an inert core, one or more coating layer(s) comprising a pharmaceutically active ingredient and a binder, an intermediate coating layer (seal coating) free from a low molecular weight water-soluble ionic compound and including a water-soluble pharmaceutical film-forming compound selected from (i) HPMC and PEG or (ii) PVP, and an outer coating layer (final or taste masking coating) free from a low molecular weight water-soluble ionic compound and comprising (i) a poly(meth)acrylate or (ii) a mixture including 60-90% (w/w) EC and 10-40% (w/w) HPMC, where the pharmaceutically active ingredient is water-soluble and includes either at least one basic group and/or a bitter taste. Further disclosed are methods for the production of such particles and pharmaceutical compositions including such particles.Type: GrantFiled: April 16, 2014Date of Patent: March 22, 2016Assignee: Boehringer Ingelheim Vetmedica GmbHInventors: Martin Folger, Stefan Lehner, Annette Grave, Norbet Poellinger, Randolph Seidler
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Patent number: 9119788Abstract: The invention relates to a method for producing particles with a length-width ratio of less than about 1.4 from a pharmaceutical substance, which method includes the following stages, that is: (a) provision of a melt of the pharmaceutical substance; (b) production of droplets of the melt by spraying into a processing chamber; (c) repeated guiding of solid particles past sprayed droplets in the processing chamber with the aid of a process gas jet which is guided in a defined way and whose temperature is fixed, depending on the solidification point of the melt, so that at least some of the droplets come into contact with particles and solidify thereon; (d) removal of particles from the processing chamber as a function of the particle size. The invention further relates to particles of pharmaceutical substances and the use thereof.Type: GrantFiled: October 31, 2013Date of Patent: September 1, 2015Assignee: GLATT GMBHInventors: Michael Jacob, Annette Grave, Reinhard Nowak
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Patent number: 9050254Abstract: The invention relates to a method for producing particles with a length-width ratio of less than about 1.4 from a pharmaceutical substance, which method includes the following stages, that is: (a) provision of a melt of the pharmaceutical substance; (b) production of droplets of the melt by spraying into a processing chamber; (c) repeated guiding of solid particles past sprayed droplets in the processing chamber with the aid of a process gas jet which is guided in a defined way and whose temperature is fixed, depending on the solidification point of the melt, so that at least some of the droplets come into contact with particles and solidify thereon; (d) removal of particles from the processing chamber as a function of the particle size. The invention further relates to particles of pharmaceutical substances and the use thereof.Type: GrantFiled: October 31, 2013Date of Patent: June 9, 2015Assignee: GLATT GMBHInventors: Michael Jacob, Annette Grave, Reinhard Nowak
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Publication number: 20140227351Abstract: Taste masked multi-layered particles include an inert core, one or more coating layer(s) comprising a pharmaceutically active ingredient and a binder, an intermediate coating layer (seal coating) free from a low molecular weight water-soluble ionic compound and including a water-soluble pharmaceutical film-forming compound selected from (i) HPMC and PEG or (ii) PVP, and an outer coating layer (final or taste masking coating) free from a low molecular weight water-soluble ionic compound and comprising (i) a poly(meth)acrylate or (ii) a mixture including 60-90% (w/w) EC and 10-40% (w/w) HPMC, where the pharmaceutically active ingredient is water-soluble and includes either at least one basic group and/or a bitter taste. Further disclosed are methods for the production of such particles and pharmaceutical compositions including such particles.Type: ApplicationFiled: April 16, 2014Publication date: August 14, 2014Applicant: BOEHRINGER INGELHEIM VETMEDICA GMBHInventors: Martin FOLGER, Stefan LEHNER, Annette GRAVE, Norbet POELLINGER, Randolph SEIDLER
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Patent number: 8741350Abstract: This application relates to taste masked multi-layered particles an inert core, one or more coating layer(s) comprising a pharmaceutically active ingredient and a binder, an intermediate coating layer (seal coating) free from a low molecular weight water-soluble ionic compound and comprising a water-soluble pharmaceutical film-forming compound selected from (i) HPMC and PEG or (ii) PVP, and an outer coating layer (final or taste masking coating) free from a low molecular weight water-soluble ionic compound and comprising (i) a poly(meth)acrylate or (ii) a mixture comprising 60-90% (w/w) EC and 10-40% (w/w) HPMC, wherein the pharmaceutically active ingredient is water-soluble and comprises either at least one basic group and/or a bitter taste. Further disclosed are methods for the production of such particles and pharmaceutical compositions comprising them.Type: GrantFiled: August 13, 2012Date of Patent: June 3, 2014Assignee: Boehringer Ingelheim Vetmedica GmbHInventors: Martin Folger, Stefan Lehner, Annette Grave, Norbert Poellinger, Randolph Seidler
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Publication number: 20140054808Abstract: The invention relates to a method for producing particles with a length-width ratio of less than about 1.4 from a pharmaceutical substance, which method includes the following stages, that is: (a) provision of a melt of the pharmaceutical substance; (b) production of droplets of the melt by spraying into a processing chamber; (c) repeated guiding of solid particles past sprayed droplets in the processing chamber with the aid of a process gas jet which is guided in a defined way and whose temperature is fixed, depending on the solidification point of the melt, so that at least some of the droplets come into contact with particles and solidify thereon; (d) removal of particles from the processing chamber as a function of the particle size. The invention further relates to particles of pharmaceutical substances and the use thereof.Type: ApplicationFiled: October 31, 2013Publication date: February 27, 2014Applicant: GLATT GMBHInventors: Michael Jacob, Annette Grave, Reinhard Nowak
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Publication number: 20140056985Abstract: The invention relates to a method for producing particles with a length-width ratio of less than about 1.4 from a pharmaceutical substance, which method includes the following stages, that is: (a) provision of a melt of the pharmaceutical substance; (b) production of droplets of the melt by spraying into a processing chamber; (c) repeated guiding of solid particles past sprayed droplets in the processing chamber with the aid of a process gas jet which is guided in a defined way and whose temperature is fixed, depending on the solidification point of the melt, so that at least some of the droplets come into contact with particles and solidify thereon; (d) removal of particles from the processing chamber as a function of the particle size. The invention further relates to particles of pharmaceutical substances and the use thereof.Type: ApplicationFiled: October 31, 2013Publication date: February 27, 2014Applicant: GLATT GMBHInventors: Michael Jacob, Annette Grave, Reinhard Nowak
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Patent number: 8597685Abstract: The invention relates to a method for producing particles with a length-width ratio of less than about 1.4 from a pharmaceutical substance, which method includes the following stages, that is: (a) provision of a melt of the pharmaceutical substance; (b) production of droplets of the melt by spraying into a processing chamber; (c) repeated guiding of solid particles past sprayed droplets in the processing chamber with the aid of a process gas jet which is guided in a defined way and whose temperature is fixed, depending on the solidification point of the melt, so that at least some of the droplets come into contact with particles and solidify thereon; (d) removal of particles from the processing chamber as a function of the particle size. The invention further relates to particles of pharmaceutical substances and the use thereof.Type: GrantFiled: August 8, 2006Date of Patent: December 3, 2013Assignee: Glatt GmbHInventors: Michael Jacob, Annette Grave, Reinhard Nowak