Abstract: Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4-position via N(H), C(O) or O moieties.

Abstract: A system, computer-readable storage medium, and a method capable of, directly or indirectly, estimating sleep states of a user based on sensor data from movement sensors and/or optical sensors.

Abstract: In various examples there is a computer-implemented method of database construction. The method comprises storing a knowledge graph comprising nodes connected by edges, each node representing a topic. Accessing a topic type hierarchy comprising a plurality of types of topics, the topic type hierarchy having been computed from a corpus of text documents. One or more text documents are accessed and the method involves labelling a plurality of the nodes with one or more labels, each label denoting a topic type from the topic type hierarchy, by, using a deep language model; or for an individual one of the nodes representing a given topic, searching the accessed text documents for matches to at least one template, the template being a sequence of words and containing the given topic and a placeholder for a topic type; and storing the knowledge graph comprising the plurality of labelled nodes.

Abstract: In various examples there is a computer-implemented method of database construction. The method comprises storing a knowledge graph comprising nodes connected by edges, each node representing a topic. Accessing a topic type hierarchy comprising a plurality of types of topics, the topic type hierarchy having been computed from a corpus of text documents. One or more text documents are accessed and the method involves labelling a plurality of the nodes with one or more labels, each label denoting a topic type from the topic type hierarchy, by, using a deep language model; or for an individual one of the nodes representing a given topic, searching the accessed text documents for matches to at least one template, the template being a sequence of words and containing the given topic and a placeholder for a topic type; and storing the knowledge graph comprising the plurality of labelled nodes.

Abstract: A system and method for aggregating and tracking content is described. In one aspect, a computer-implemented method includes forming a consolidated graphical user interface that tracks activities related to a project identifier. The project identifier identifies aggregated content. A project search query is received on the consolidated graphical user interface. The system identifies the project identifier based on the project search query, and presents at least one of a content item, a file, a folder, a user identifier, a user message, a meeting identifier, and a website identifier associated with the project identifier. The system registers selected items with the project identifier with a user of the consolidated graphical user interface, and forms the aggregated content assigned to the project identifier and to the user based on the registered selection.

Abstract: A system and method for aggregating and tracking content is described. In one aspect, a computer-implemented method includes forming a consolidated graphical user interface that tracks activities related to a project identifier. The project identifier identifies aggregated content. A project search query is received on the consolidated graphical user interface. The system identifies the project identifier based on the project search query, and presents at least one of a content item, a file, a folder, a user identifier, a user message, a meeting identifier, and a website identifier associated with the project identifier. The system registers selected items with the project identifier with a user of the consolidated graphical user interface, and forms the aggregated content assigned to the project identifier and to the user based on the registered selection.

Abstract: A method of providing a geographically distributed live mixed-reality meeting is described. The method comprises receiving, from a camera at a first endpoint, a live video stream; generating an mixed reality view incorporating the received video stream; rendering the mixed reality view at a display at the first endpoint and transmitting the mixed reality view to at least one other geographically distant endpoint; receiving data defining a bounding area; calculating a real world anchor for the bounding area using the data defining the bounding area; rendering the bounding area in the mixed reality view at a real world position determined using the real world anchor; and applying different rule sets to content objects placed into the mixed reality view by users dependent upon the position of the content objects relative to the bounding area in real world space.

Abstract: A system, computer-readable storage medium, and a method capable of, directly or indirectly, estimating sleep states of a user based on sensor data from movement sensors and/or optical sensors.

Abstract: A method of providing a geographically distributed live mixed-reality meeting is described. The method comprises receiving, from a camera at a first endpoint, a live video stream; generating an mixed reality view incorporating the received video stream; rendering the mixed reality view at a display at the first endpoint and transmitting the mixed reality view to at least one other geographically distant endpoint; receiving data defining a bounding area; calculating a real world anchor for the bounding area using the data defining the bounding area; rendering the bounding area in the mixed reality view at a real world position determined using the real world anchor; and applying different rule sets to content objects placed into the mixed reality view by users dependent upon the position of the content objects relative to the bounding area in real world space.

Abstract: A method of providing a geographically distributed live mixed-reality meeting is described. The method comprises receiving, from a camera at a first endpoint, a live video stream; generating an mixed reality view incorporating the received video stream; rendering the mixed reality view at a display at the first endpoint and transmitting the mixed reality view to at least one other geographically distant endpoint; receiving data defining a bounding area; calculating a real world anchor for the bounding area using the data defining the bounding area; rendering the bounding area in the mixed reality view at a real world position determined using the real world anchor; and applying different rule sets to content objects placed into the mixed reality view by users dependent upon the position of the content objects relative to the bounding area in real world space.

Abstract: Fluid valve actuator apparatus having internal tubing and anti-rotation features are disclosed. An example actuator apparatus includes a diaphragm plate defining a first pressure chamber and a second pressure chamber opposite the first pressure chamber, a first internal fluid passageway in fluid communication with atmosphere, and a second internal fluid passageway to receive a control fluid from a controller. The example apparatus also includes a tube fluidly coupling the first or second internal fluid passageway to the first pressure chamber via an opening in the diaphragm plate, where a first center axis of the tube is offset from a second center axis of the diaphragm plate, and where the tube passing through the diaphragm plate is to prevent the diaphragm plate from rotating.

Abstract: Diaphragm actuators having adjustable actuation force are disclosed herein. An example apparatus includes a spring seat coupled to a diaphragm of an actuator. The spring seat is to contact a spring and is to be coupled to a stem. The diaphragm is to displace the stem based on a force provided to the diaphragm, and the stem is to control a fluid valve. The example apparatus also includes an adjuster to adjust an amount of force provided to the spring seat by the spring.

Abstract: Fluid valve actuator apparatus having internal tubing and anti-rotation features are disclosed. An example actuator apparatus includes a diaphragm plate defining a first pressure chamber and a second pressure chamber opposite the first pressure chamber, a first internal fluid passageway in fluid communication with atmosphere, and a second internal fluid passageway to receive a control fluid from a controller. The example apparatus also includes a tube fluidly coupling the first or second internal fluid passageway to the first pressure chamber via an opening in the diaphragm plate, where a first center axis of the tube is offset from a second center axis of the diaphragm plate, and where the tube passing through the diaphragm plate is to prevent the diaphragm plate from rotating.

Abstract: An external programmer, such as an external clock synchronization tool, can be used to update or modify the stimulation protocol and/or parameters on an implanted electrical stimulator. In particular, described herein are external clock synchronization tools that can be used to calibrate a low-power clock of the implanted electrical stimulator. These tools may also be used to provide command overrides, including suspending or delaying neurostimulation, stopping neurostimulation, and/or on-demand neurostimulation.

Abstract: Fluid valve actuator apparatus having internal tubing and anti-rotation features are disclosed. An example actuator apparatus includes an actuator casing and a diaphragm plate disposed within the actuator casing. The diaphragm plate defines a first pressure chamber and a second pressure chamber opposite the first pressure chamber. A yoke couples the actuator casing to a fluid valve. The yoke includes a first internal fluid passageway in fluid communication with atmosphere and a second internal fluid passageway to receive a control fluid from a controller. A tube fluidly couples the first or second internal fluid passageway to the first pressure chamber via an opening in the diaphragm plate. The tube also prevents the diaphragm plate from rotating relative to the actuator casing.

Abstract: Diaphragm actuators having adjustable actuation force are disclosed herein. An example apparatus includes a spring seat coupled to a diaphragm of an actuator. The spring seat is to contact a spring and is to be coupled to a stem. The diaphragm is to displace the stem based on a force provided to the diaphragm, and the stem is to control a fluid valve. The example apparatus also includes an adjuster to adjust an amount of force provided to the spring seat by the spring.

Abstract: Fluid valve actuator apparatus having internal tubing and anti-rotation features are disclosed. An example actuator apparatus includes an actuator casing and a diaphragm plate disposed within the actuator casing. The diaphragm plate defines a first pressure chamber and a second pressure chamber opposite the first pressure chamber. A yoke couples the actuator casing to a fluid valve. The yoke includes a first internal fluid passageway in fluid communication with atmosphere and a second internal fluid passageway to receive a control fluid from a controller. A tube fluidly couples the first or second internal fluid passageway to the first pressure chamber via an opening in the diaphragm plate. The tube also prevents the diaphragm plate from rotating relative to the actuator casing.

Abstract: A valve shaft apparatus with a rotary valve includes a shaft having a first portion in an opening of a valve body and a second portion in a cavity of a closure member. A first seal is coupled to the first portion to prevent fluid leakage into the opening of the valve body, where the first seal defines a first leakage detection area. A second seal is coupled to the second portion to prevent fluid leakage into the cavity, the second seal is to define a second leakage detection area. A passageway in the shaft is fluidly coupled to the first and second leakage detection areas to provide an indication of fluid leakage past the first seal in the opening or to detect fluid leakage past the second seal in the cavity. The passageway is in fluid communication with a shaft outlet formed in an end of the shaft.

Abstract: Actuators having override apparatus are described herein. An example actuator having an override apparatus includes a first actuator stem coupled to a control actuation member. The override apparatus is operatively coupled to the actuator. A spring is coupled to an override member to move the first actuator stem to a predetermined position in response to an override condition.

Abstract: An example valve shaft apparatus for use with a rotary valve disclosed herein includes a shaft having a first portion to be positioned in an opening of a valve body and a second portion to be positioned in a cavity of a closure member. A first seal is coupled to the first portion of the shaft to prevent fluid leakage into the opening of the valve body, where the first seal defines a first leakage detection area adjacent the first seal. A second seal is coupled to the second portion to prevent fluid leakage into the cavity of the closure member, where the first seal is spaced from the second seal and the second seal is to define a second leakage detection area adjacent the second seal. A passageway is formed in the shaft and fluidly coupled to the first and second leakage detection areas to provide an indication of fluid leakage past the first seal in the opening or to detect fluid leakage past the second seal in the cavity.