Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: A generator injection tool is provided. The generator injection tool injects an adhesive into a generator that includes a rotor positioned within a stator having a stator vent, the stator and rotor having a gap therebetween. The generator injection tool includes a first carriage sized to fit within the gap, a tube, a first motor, a controller, and an adhesive source. An end of the tube is movable between a first position in which the end is outside of the stator vent and a second position within the stator vent. The first motor is operable to move the tube between the first position and the second position. The controller is operable to selectively activate the first motor to position the end of the tube within the stator vent. The adhesive source moves the adhesive through the tube end to inject a portion of the adhesive into the stator vent.

Abstract: Various embodiments of a system and method for capturing changes in trade information that impact trade authorization and for updating a chain state on a distributed chain database that is used to authorize trades are disclosed herein. In some embodiments, the system comprises: a trade controller configured to obtain a current state from a local database; a rules engine configured to be invoked by the trade controller to apply a ruleset to data extracted from the local database to generate an updated state; an operation auto detector configured to generate a plan to update a chain state on the distributed chain database based at least in part on the updated state; and an execution engine configured to execute the plan and to generate an updated chain state that is used to authorize trades.

Abstract: The digital amplification methods and kits provide the ability to estimate the fetal fraction of cell-free DNA (cfDNA) in a maternal sample, e.g., plasma or serum, by analysis of target sites that are differentially methylated in fetal and maternal cfDNA.

Abstract: Methods are provided for joining a composite component, such as a rotor blade of a wind turbine. Accordingly, a first blade segment is provided and a bladder assembly is positioned thereon. Additionally, an adhesive element is positioned in a first position on the first blade segment. A second blade segment is positioned with the first blade segment so as to define an inner cavity therebetween. The inner cavity contains the adhesive element and the bladder assembly, but the adhesive element does not contact the second blade segment while in the first position. The bladder assembly is inflated to transition the adhesive element to a second position in contact with both the first blade segment and the second blade segment. With the adhesive element in contact with both blade segments, the adhesive element is allowed to cure in order to secure the blade segments to one another.

Abstract: A method for joining rotor blade segments of a rotor blade includes providing a first blade segment defining a concave cross-sectional shape having at least one internal flange. The method also includes providing a second blade segment having at least one external flange. Further, the method includes positioning the internal flange(s) of the blade segment internal of the external flange(s) of the second blade segment at a joint. Moreover, the method includes placing at least one inflatable internal bladder within an inner cavity of the rotor blade at the joint. In addition, the method includes inflating the internal bladder(s) so as to provide internal pressure thereto so as to align the internal flange(s) with the external flange(s) and to maintain contact between the internal flange(s) and the external flange(s). Thus, the method also includes securing the first and second blade segments together while maintaining the internal pressure via the internal bladder(s).

Abstract: A method for forming an electronic chip assembly. A first metal plate is coupled to a first side of a substrate to form a backing plate. A first cavity is created extending through the substrate to extend at least to the first metal plate. An electronic component is bonded to the substrate such that the electronic component is located within the first cavity. A second metal plate, having a second cavity, is disposed to a second side of the substrate, and over the first cavity such that the electronic component is encased within the first and second cavities by the first and second metal plates.

Abstract: Devices, systems, and/or methods that can facilitate plating one or more metal layers onto a niobium-titanium substrate are provided. According to an embodiment, a device can comprise a niobium-titanium substrate. The device can further comprise a first metal layer plated on a portion of the niobium-titanium substrate. The device can further comprise a second metal layer plated on the first metal layer. The device can further comprise a third metal layer plated on the second metal layer.

Abstract: Devices, systems, and/or methods that can facilitate plating one or more metal layers onto a niobium-titanium substrate are provided. According to an embodiment, a device can comprise a niobium-titanium substrate. The device can further comprise a first metal layer plated on a portion of the niobium-titanium substrate. The device can further comprise a second metal layer plated on the first metal layer. The device can further comprise a third metal layer plated on the second metal layer.

Abstract: A method for forming an electronic chip assembly. A first metal plate is coupled to a first side of a substrate to form a backing plate. A first cavity is created extending through the substrate to extend at least to the first metal plate. An electronic component is bonded to the substrate such that the electronic component is located within the first cavity. A second metal plate, having a second cavity, is disposed to a second side of the substrate, and over the first cavity such that the electronic component is encased within the first and second cavities by the first and second metal plates.

Abstract: A method for forming an electronic chip assembly. A first metal plate is coupled to a first side of a substrate to form a backing plate. A first cavity is created extending through the substrate to extend at least to the first metal plate. An electronic component is bonded to the substrate such that the electronic component is located within the first cavity. A second metal plate, having a second cavity, is disposed to a second side of the substrate, and over the first cavity such that the electronic component is encased within the first and second cavities by the first and second metal plates.

Abstract: Described is an energy curable ink for use in the production of layered composites the ink comprising 3 to 50% by weight of aminoacrylate as defined herein, 5 to 60% by weight of hydroxyl functional acrylate monomer and wherein the non-volatile content of the ink is not less than 45% by weight. Also described is a layered composite having a layer of the energy curable ink on a substrate and a process for producing a layered composite in which the energy curable ink according to the present invention is printed onto a substrate and then cured.

Abstract: The application relates to a method, an electronic device and a program for recommending a foundation product from.

Abstract: The present invention provides a method for printing energy-curable ink and coating compositions that have good adhesion to substrates, good print quality, solvent and scratch resistance, and low potential for migration of uncured monomers. The method comprises the steps of printing the ink or coating onto a substrate; partially curing the printed ink or coating by irradiating with UV energy; optionally printing and partially UV curing additional ink layers printed on the first layer; and completing curing via exposure to electron beam radiation, wherein the EB cure dose is greater than or equal to 20 kGy, and the accelerating voltage is greater than or equal to 70 keV.

Abstract: A method of operation of a computer system comprising: receiving a tire image for a target tire; determining an analyzability for the target tire based on a wear model including the tire image; analyzing a wear level for the target tire based on the analyzability meets or exceeds a usable threshold; generating an augmented reality image for the wear level for the target tire; and communicating the augmented reality image for displaying the wear level for the target tire.

Abstract: Techniques are described for managing cookies, including separately managing cookie data associated with different browser tabs. Cookie management includes the isolation of whitelisted cookies from server responses into background storage and then back onto server requests, removing those cookies from the response header and thus from the cookie store. This isolation is managed with the concept of tab ownership between parent and child tabs to maintain isolation separately for each owner (e.g., the parent) and its children. Exposure to client pages is handled by placing those cookies into a keyed location in session storage for every tab where that cookie is to be visible. An event is then triggered for that client page to let it know that session storage has been updated.

Abstract: Electron beam curable compositions including polyols, and any blend of ethylenically unsaturated monomers and oligomers. The polyols of the invention are preferably essentially free of any ethylenically unsaturated groups, have greater than one hydroxy group and preferably have boiling points in excess of 170° C.

Abstract: A method for forming an electronic chip assembly. A first metal plate is coupled to a first side of a substrate to form a backing plate. A first cavity is created extending through the substrate to extend at least to the first metal plate. An electronic component is bonded to the substrate such that the electronic component is located within the first cavity. A second metal plate, having a second cavity, is disposed to a second side of the substrate, and over the first cavity such that the electronic component is encased within the first and second cavities by the first and second metal plates.

Abstract: Energy curable compositions including polyols, and any blend of ethylenically unsaturated monomers and oligomers. The polyols of the invention are essentially free of any ethylenically unsaturated groups. It is preferred that the polyol substances according to the invention have greater than one hydroxy group and preferably have boiling points in excess of 170° C. The compositions of the invention are particularly useful for the printing or coating of food packaging and may be applied via any printing or coating method, although inkjet printing is a preferred method.

Abstract: Devices, systems, and/or methods that can facilitate plating one or more metal layers onto a niobium-titanium substrate are provided. According to an embodiment, a device can comprise a niobium-titanium substrate. The device can further comprise a first metal layer plated on a portion of the niobium-titanium substrate. The device can further comprise a second metal layer plated on the first metal layer. The device can further comprise a third metal layer plated on the second metal layer.