Patents by Inventor Anthony John Murray
Anthony John Murray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10989709Abstract: A method of recovering a target from a sample is provided. The method of recovering the target follows different steps. The steps include providing a binding element, wherein the binding elements are immobilized on a solid support, adding the sample comprising the target to the binding element to form a binding element-target complex; washing the binding element-target complex; and eluting the target from the binding element-target complex. The system for reversible detection of target in a range from 2 to 1,000,000 bind/release cycles is also provided.Type: GrantFiled: March 22, 2017Date of Patent: April 27, 2021Assignee: CYTIVA SWEDEN ABInventors: Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj, Anthony John Murray
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Patent number: 10359419Abstract: A method of recovering a target from a sample is provided. The method comprises the adding a substrate coupled binding element to the sample comprising the target to form a substrate coupled binding element-target complex; precipitating the complex by changing one or more environmental conditions of the substrate and recovering the target and the substrate coupled binding-element under mild conditions.Type: GrantFiled: October 2, 2013Date of Patent: July 23, 2019Assignee: General Electric CompanyInventors: Anthony John Murray, Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj
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Publication number: 20180370827Abstract: A method of operating a waste water treatment plant (WWTP) having at least one of an aerobic digester (AD) and a membrane bioreactor (MBR) is described. The method of operating AD is comprised of monitoring and controlling AD in real-time using an online extended Kalman filter (EKF) having a online dynamic model of AD. The EKF uses real-time AD measured data, and online dynamic model of AD to update adapted model parameters and estimate model based inferred variables for AD, which are used for AD control by AD control system having supervisory and low-level control layers. The method of operating MBR is similar to that of AD. The supervisory control ensures the WWTP satisfying the effluent quality requirement while minimize the operation cost. A WWTP having at least one of an AD or MBR is disclosed. The method of operating a WWTP can be implemented using a computer.Type: ApplicationFiled: August 14, 2018Publication date: December 27, 2018Applicant: General Electric CompanyInventors: Aditya Kumar, Anthony John Murray, Ruijie Shi, Zhaoyang Wan, Mustafa Tekin Dokucu, Vijaysai Prasad
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Patent number: 10046995Abstract: A method of operating a waste water treatment plant (WWTP) having at least one of an aerobic digester (AD) and a membrane bioreactor (MBR) is described. The method of operating AD is comprised of monitoring and controlling AD in real-time using an online extended Kalman filter (EKF) having a online dynamic model of AD. The EKF uses real-time AD measured data, and online dynamic model of AD to update adapted model parameters and estimate model based inferred variables for AD, which are used for AD control by AD control system having supervisory and low-level control layers. The method of operating MBR is similar to that of AD. The supervisory control ensures the WWTP satisfying the effluent quality requirement while minimize the operation cost. A WWTP having at least one of AD or MBR is disclosed. The method of operating a WWTP can be implemented using a computer.Type: GrantFiled: July 25, 2012Date of Patent: August 14, 2018Assignee: General Electric CompanyInventors: Aditya Kumar, Anthony John Murray, Ruijie Shi, Zhaoyang Wan, Mustafa Tekin Dokucu, Vijaysai Prasad
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Patent number: 9958441Abstract: A biosensing FET device, comprising a plurality of nanostructured SOI channels, that is adapted to operate in solutions having a high ionic strength and provides improves sensitivity and detection. Generally, the biosensing device comprises an underlying substrate layer, an insulator and a semiconductor layer and a plurality of channels in the semiconductor layer comprising a plurality of whole or partially formed nanopores in the channels.Type: GrantFiled: July 7, 2016Date of Patent: May 1, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: An-Ping Zhang, Anthony John Murray, Rui Chen
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Publication number: 20170267716Abstract: Provided herein are aptamer-polymer conjugates which are responsive to environmental stimuli and are useful in selective purification of untagged target polypeptides.Type: ApplicationFiled: March 16, 2016Publication date: September 21, 2017Inventors: Anthony John Murray, Andrew David Pris, Erik Leeming Kvam, Nandini Nagraj, Eugene Pauling Boden, Ernest William Kovacs, Louisa Ruth Carr, Rui Chen, Tiberiu Mircea Siclovan, Kelly Scott Chichak
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Patent number: 9765375Abstract: Methods for developing a binding-element are provided. A mixture comprising a target molecule, a plurality of oligonucleotides and a ligase is provided, followed by binding the oligonucleotides to the target molecule to form an oligonucleotides-target molecule complex. The oligonucleotides bound to the target molecule are ligated to form the binding-element. The binding-elements are separated from the mixture.Type: GrantFiled: June 28, 2013Date of Patent: September 19, 2017Assignee: General Electric CompanyInventors: Anthony John Murray, John Richard Nelson
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Publication number: 20170191992Abstract: A method of recovering a target from a sample is provided. The method of recovering the target follows different steps. The steps include providing a binding element, wherein the binding elements are immobilized on a solid support, adding the sample comprising the target to the binding element to form a binding element-target complex; washing the binding element-target complex; and eluting the target from the binding element-target complex. The system for reversible detection of target in a range from 2 to 1,000,000 bind/release cycles is also provided.Type: ApplicationFiled: March 22, 2017Publication date: July 6, 2017Inventors: Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj, Anthony John Murray
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Publication number: 20160355426Abstract: Methods for treatment of sludge with microwave irradiation for improving its dewatering are provided. In one embodiment, the method includes exposing the sludge to microwave irradiation at an absorbed power density of between about 7 W/ml and about 13 W/ml. Turbidity, total solids content and overall dewaterability are improved when the microwave irradiation treatment is combined with another method for dewatering sludge, such as enzyme treatment, conditioning with a flocculating agent and mechanical dewatering.Type: ApplicationFiled: August 23, 2016Publication date: December 8, 2016Inventors: Vasile Bogdan Neculaes, Stephen Robert Vasconcellos, Brian Christopher Moore, Anthony John Murray, June Klimash, Kenneth Roger Conway, Tracy Lynn Paxon, Michael Brian Salerno, Casey L. Renko
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Publication number: 20160313318Abstract: A biosensing FET device, comprising a plurality of nanostructured SOI channels, that is adapted to operate in solutions having a high ionic strength and provides improves sensitivity and detection. Generally, the biosensing device comprises an underlying substrate layer, an insulator and a semiconductor layer and a plurality of channels in the semiconductor layer comprising a plurality of whole or partially formed nanopores in the channels.Type: ApplicationFiled: July 7, 2016Publication date: October 27, 2016Inventors: An-Ping Zhang, Anthony John Murray, Rui Chen
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Patent number: 9409769Abstract: A biosensing FET device, comprising a plurality of nanostructured SOI channels, that is adapted to operate in solutions having a high ionic strength and provides improves sensitivity and detection. Generally, the biosensing device comprises an underlying substrate layer, an insulator and a semiconductor layer and a plurality of channels in the semiconductor layer comprising a plurality of whole or partially formed nanopores in the channels.Type: GrantFiled: November 30, 2007Date of Patent: August 9, 2016Assignee: GENERAL ELECTRIC COMPANYInventors: An-Ping Zhang, Anthony John Murray, Rui Chen
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Publication number: 20160202254Abstract: A biosensing FET device, comprising a plurality of nanostructured SOI channels, that is adapted to operate in solutions having a high ionic strength and provides improves sensitivity and detection. Generally, the biosensing device comprises an underlying substrate layer, an insulator and a semiconductor layer and a plurality of channels in the semiconductor layer comprising a plurality of whole or partially formed nanopores in the channels.Type: ApplicationFiled: November 30, 2007Publication date: July 14, 2016Applicant: General Electric CompanyInventors: An-Ping Zhang, Anthony John Murray, Rui Chen
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Publication number: 20150093839Abstract: A method of recovering a target from a sample is provided. The method of recovering the target follows different steps. The steps include providing a binding element, wherein the binding elements are immobilized on a solid support, adding the sample comprising the target to the binding element to form a binding element-target complex; washing the binding element-target complex; and eluting the target from the binding element-target complex. The system for reversible detection of target in a range from 2 to 1,000,000 bind/release cycles is also provided.Type: ApplicationFiled: October 2, 2013Publication date: April 2, 2015Applicant: General Electric CompanyInventors: Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj, Anthony John Murray
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Publication number: 20150093820Abstract: A method of recovering a target from a sample is provided. The method comprises the adding a substrate coupled binding element to the sample comprising the target to form a substrate coupled binding element-target complex; precipitating the complex by changing one or more environmental conditions of the substrate and recovering the target and the substrate coupled binding-element under mild conditions.Type: ApplicationFiled: October 2, 2013Publication date: April 2, 2015Applicant: General Electric CompanyInventors: Anthony John Murray, Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj
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Publication number: 20150034553Abstract: A method of operating a waste water treatment plant (WWTP) having at least one of an aerobic digester (AD) and a membrane bioreactor (MBR) is described. The method of operating AD is comprised of monitoring and controlling AD in real-time using an online extended Kalman filter (EKF) having a online dynamic model of AD. The EKF uses real-time AD measured data, and online dynamic model of AD to update adapted model parameters and estimate model based inferred variables for AD, which are used for AD control by AD control system having supervisory and low-level control layers. The method of operating MBR is similar to that of AD. The supervisory control ensures the WWTP satisfying the effluent quality requirement while minimize the operation cost. A WWTP having at least one of AD or MBR is disclosed. The method of operating a WWTP can be implemented using a computer.Type: ApplicationFiled: July 25, 2012Publication date: February 5, 2015Applicant: General Electric CompanyInventors: Aditya Kumar, Anthony John Murray, Ruijie Shi, Zhaoyang Wan, Mustafa Tekin Dokucu, Vijaysai Prasad
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Patent number: 8940521Abstract: A composite detection device having in-line desalting is provided. The composite detection device comprises a membrane configured for desalting at least a portion of an analyte stream, and a nanostructure for detecting a bio-molecule or a bio-molecule interaction, wherein the nanostructure and the membrane are arranged such that an analyte stream desalted at least in part by the membrane is detected by the nanostructure. A bio-sending detection system having the composite detection device and method of fabrication of the composite detection device are also provided.Type: GrantFiled: November 29, 2007Date of Patent: January 27, 2015Assignee: General Electric CompanyInventors: Anthony John Murray, Anping Zhang, Rui Chen
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Publication number: 20150004611Abstract: Methods for developing a binding-element are provided. A mixture comprising a target molecule, a plurality of oligonucleotides and a ligase is provided, followed by binding the oligonucleotides to the target molecule to form an oligonucleotides-target molecule complex. The oligonucleotides bound to the target molecule are ligated to form the binding-element. The binding-elements are separated from the mixture.Type: ApplicationFiled: June 28, 2013Publication date: January 1, 2015Inventors: Anthony John Murray, John Richard Nelson
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Patent number: 8622223Abstract: A method of making a membrane assembly is provided. The method comprises forming an inorganic membrane layer disposed on a substrate, and forming a plurality of macropores in the substrate at least in part using anodization. Further, a membrane assembly is provided. The membrane assembly comprises a filtering membrane that is coupled to an anodized substrate comprising a plurality of macropores.Type: GrantFiled: December 17, 2008Date of Patent: January 7, 2014Assignee: General Electric CompanyInventors: Anping Zhang, Azar Alizadeh, Joleyn Eileen Balch, Rui Chen, Anthony John Murray, Vicki Herzl Watkins, Oliver Charles Boomhower, Reed Roeder Corderman, Peter Paul Gipp
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Publication number: 20130161255Abstract: Methods for treatment of sludge with microwave irradiation for improving its dewatering are provided. In one embodiment, the method includes exposing the sludge to microwave irradiation at a power density of between about 3 W/ml and about 17 W/ml. Turbidity, total solids content and overall dewaterability are improved when the microwave irradiation treatment is combined with another method for dewatering sludge, such as enzyme treatment, conditioning with a flocculating agent and mechanical dewatering.Type: ApplicationFiled: December 21, 2011Publication date: June 27, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Vasile Bogdan NECULAES, Stephen VASCONCELLOS, Brian MOORE, Anthony John MURRAY, June KLIMASH, Kenneth CONWAY, Tracy PAXON, Michael SALERNO, Casey RENKO
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Patent number: 8377277Abstract: Electrophoresis systems and methods comprise an electrophoresis device, wherein the electrophoresis comprises a loading channel, a separation channel, and an injection channel. The loading channel is in fluid communication with a first and second sample port. The separation channel is connected to the loading channel to form a first intersection, and an injection channel connected to the separation channel to form a second intersection and in fluid communication with a first reservoir, and wherein the separation channel is in fluid communication with a second reservoir. The electrophoresis system further comprises two electrodes coupled to the first sample port and the first reservoir, and the first sample port and the second reservoir, respectively, that are adapted to move the sample into the loading channel towards the first reservoir and form a sample plug in the separation channel, and to further move the sample plug into the separation channel towards the second reservoir.Type: GrantFiled: October 22, 2008Date of Patent: February 19, 2013Assignee: General Electric CompanyInventors: Jun Xie, Wei-Cheng Tian, Shashi Thutupalli, Li Zhu, Anthony John Murray, Erin Jean Finehout