Abstract: The present invention relates to a compound of general formula (I), wherein R1 is OCH2CH2OCH3 or OCH3, R?1 is H or OH, R2 is Cl, F, Br or I, with the proviso that when: R1 is OCH2CH2OCH3 then R?1 is H, R1 is OCH3 then R?1 is OH, its pharmaceutically acceptable salts and/or optical isomers, tautomers, solvates or isotopic variations thereof. The invention also relates to said compounds for use in the treatment of cancer, namely solid tumor cancer, and preferably those selected from melanoma, colon, lung, pancreas, kidney, Merkel carcinoma, squamous cell carcinoma, prostate, breast and bladder. The invention also relates to a pharmaceutical composition comprising said compounds.

Abstract: The present invention relates to a compound of general formula (I)for use in the treatment of a disease selected from lymphomas and leukemia.

Abstract: Systems and methods of screening memory cells by modulating bitline and/or wordline voltage. In a read operation, the wordline may be overdriven or underdriven as compared to a nominal operating voltage on the wordline. In a write operation, the one or both of the bitline and wordline may be overdriven or underdriven as compared to a nominal operating voltage of each. A built-in self test (BIST) system for screening a memory array has bitline and wordline margin controls to modulate bitline and wordline voltage, respectively, in the memory array.

Abstract: A method of forming a composite article includes impregnating an inorganic fiber preform with a slurry composition. The slurry composition includes a particulate, a solvent, and a pre-gellant material. Gelling of the pre-gellant material in the slurry composition is initiated to immobilize the particulate and yield a gelled article, and substantially all solvent is removed from the gelled article to form a green composite article. The green composite article is then infiltrated with a molten infiltrant to form the composite article.

Abstract: The present invention relates to a compound of general formula (I): said compound being as defined in claim (1). The invention also relates to a pharmaceutical composition comprising: —a compound of general formula (I) as defined in claim (12) and, —at least one antibody selected from an anti-PD1 antibody, an anti-CTLA4 antibody, an anti-PD-L1 antibody and a mixture of two or more thereof. The invention also relates to a compound of general formula (I) as defined in claim (17) for use in the treatment of cancer, said cancer being preferably selected from melanoma, bladder, kidney, prostate, colon, lung, breast and blood cancer.

Abstract: A device is provided for pooling a fluid from a container unit having at least one container, and includes an inlet port having at least one inlet channel configured for receiving the fluid or ambient air, and an outlet port having at least one outlet channel configured for delivering the fluid to an attachment. Both inlet and outlet ports are disposed on the device. A cavity is provided for accommodating insertion of the container unit for pooling the fluid from the at least one container. At least one spike is disposed in the cavity and configured for puncturing a stopper of the at least one container when the container unit transitions from an upper position to a lower position.

Abstract: Axial stress or similar properties in a stressed tendon or ligament are measured by mechanical excitation of a shear wave in the tendon or ligament measured using ultrasonic displacement techniques at least two different longitudinal positions to derive a shear wave propagation speed. This shear wave propagation speed may be equated to an axial stress on the tissue using a model. Rapidly repeated measurements allow dynamic axial stress measurements to be obtained for clinical study.

Abstract: Systems for videoconferencing are designed for where people are seated around a video conferencing system. The systems include a camera so the far site can see the local participants and the systems include displays that show the far site. The displays are properly aligned with the cameras so that when people at the far site view the displayed images of the near site, it looks like they have eye contact with the near site. Obtaining the alignments of the camera and the displays to provide this apparent eye contact result requires meeting a series of different constraints relating to the various sizes and angles of the components and the locations of the participants.

Abstract: The present application discloses a method for three-dimensional deposition printing to manufacture optical elements including ophthalmic devices by controlling the level of oxygen in the polymerization mixture and the printing environment to achieve precision in form and smoothness of surface for image quality optical performance.

Abstract: A method of creating and attaching membrane panels of thin film, fabric or laminate to a tubular framework, that keeps the membrane tight over a wide range of air temperature and effectively seals the edges and hubs to provide a weather tight enclosure. A second aspect of this invention is a complete system for building enclosed geodesic domes and space frames using this method and addresses anchoring, external shading, venting, creating entryways and interior partitioning of said geodesic domes.

Abstract: This invention relates to comfortable ophthalmic devices and methods of producing such devices.

Abstract: An adaptive voltage scaling technique includes using a temperature sensor arranged on a semiconductor die to determine a current die temperature of the semiconductor die, using a performance sensor arranged on a semiconductor die to determine a current performance metric of the semiconductor die, determining whether the current performance metric matches an expected performance metric based at least partially on the current die temperature and, if the current performance metric does not match the expected performance metric, indicate a performance sensor error, when a performance sensor error is indicated, determining an updated power supply voltage for correcting the performance sensor error, and causing a current power supply voltage supplied by a power supply voltage source of the semiconductor die to be changed to the updated power supply voltage.

Abstract: Axial stress or similar properties in a stressed connective tissue may be assessed during surgery by excitation of the ligament to create a shear wave allowing measurement of the shear wave velocity which has been identified as having a component related to axial stress.

Abstract: A device for random number generation based on an optical process of quantum nature, including a light source emitting photons randomly, a light detector adapted to absorb the randomly emitted photons and to measure a number n of photons produced by the light source in a time interval T, and a randomness extractor. The detector includes a photon sensor acting as a photon-to-electron converter, an amplifier for converting the electron signal received from the photon sensor into a voltage and amplifying the voltage signal, as well as an analog-to-digital converter for processing the amplified signal received from the amplifier by encoding the amplified signal into digital values and sending these digital values to the randomness extractor for further processing such as to produce quantum random numbers (QRNs) based on the number of photons produced by the light source in a time interval T.