Abstract: A power generation system includes a shroud that defines a fluid flow path. A gas turbine engine is in the fluid flow path, and the gas turbine engine includes a compressor, a combustor downstream from the compressor, and a turbine downstream from the combustor. An electric generator is in the fluid flow path upstream from the turbine, and the electric generator includes a rotor coaxially aligned with the turbine. A plurality of non-lubricated bearings rotatably support the gas turbine engine.

Abstract: A method and apparatus are disclosed for simultaneously providing a plurality of probe response signals indicative of electrical activity at a respective plurality of locations in a patient. The apparatus comprises a rigid needle shaft element comprising a piercing tip and a substrate supporting a plurality of electrode tracks, secured to the needle shaft element and extending along the shaft element away from the piercing tip. Each electrode track extends from a sensing end region arranged for providing a respective probe response signal responsive to localised electrical activity, along the region of the substrate, to a respective bond pad connection region. Recording surface regions of the plurality of electrode tracks are spaced apart in a plurality of substantially linear spaced apart configurations along the substrate.

Abstract: A method of cutting (e.g. micro-milling) brittle materials where a protective ductile layer is present on the brittle material during the cutting step. The method offers an improved edge quality of the machined profile relative to previous cutting (e.g. micro-milling) techniques. A machined product obtained by or obtainable by this method is disclosed.

Abstract: A high dielectric constant metal-insulator structure, including an electrode comprising NiOx wherein 1<x?1.5, and a high k dielectric material in contact with the electrode. The structure may have a further electrode in contact with the high k dielectric material, to form a metal-insulator-metal (MIM) capacitor, e.g., including a bottom electrode comprising NiOx wherein 1<x?1.5, a high k dielectric material overlying the bottom electrode, and a top electrode comprising NiOx wherein 1<x?1.5. The NiOx electrodes in such applications are oxide-stable, high work function electrodes that avoid deterioration of work function and conductivity during electronic device fabrication involving elevated temperature annealing.

Abstract: A method and apparatus are disclosed for simultaneously providing a plurality of probe response signals indicative of electrical activity at a respective plurality of locations in a patient. The apparatus comprises a rigid needle shaft element comprising a piercing tip and a substrate supporting a plurality of electrode tracks, secured to the needle shaft element and extending along the shaft element away from the piercing tip. Each electrode track extends from a sensing end region arranged for providing a respective probe response signal responsive to localised electrical activity, along the region of the substrate, to a respective bond pad connection region. Recording surface regions of the plurality of electrode tracks are spaced apart in a plurality of substantially linear spaced apart configurations along the substrate.

Abstract: A high dielectric constant metal-insulator structure, including an electrode comprising NiOx wherein 1<x?1.5, and a high k dielectric material in contact with the electrode. The structure may have a further electrode in contact with the high k dielectric material, to form a metal-insulator-metal (MIM) capacitor, e.g., including a bottom electrode comprising NiOx wherein 1<x?1.5, a high k dielectric material overlying the bottom electrode, and a top electrode comprising NiOx wherein 1<x?1.5.

Abstract: The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a Toll-like Receptor 9 antagonist sufficient to prevent the activation of Toll-like Receptor 9 by fetal DNA. The invention further provides compositions comprising a Toll-like Receptor 9 antagonist for use in the methods of the invention. The compositions and methods of the present invention enhance gestation and therefore improve neonatal morbidity and mortality.

Abstract: A method, system, and computer program product are provided for remotely controlling a supply of power to a plurality of electrical appliances. In response to attaching a plug of a first electrical appliance of a plurality of electrical appliances to a first socket of the one or more sockets connected to a main power supply, a control system activates a transceiver at a first of the first socket and the plug; stimulates, via the transceiver, a tag at a second of the first socket and the plug to determine a unique identifier of the tag. The control system receives the unique identifier of the tag from the transceiver and uses the unique identifier to activate/deactivate the transceiver which connects/disconnects the main power supply from the first electrical appliance.

Abstract: Disclosed are assays for the determination and quantification of the phosphorylation of TRAM (Trif-related adaptor molecule). TRAM is rapidly phosphorylated upon LPS stimulation by protein kinase C epsilon (PKC?) and that this phosphorylation is vital for TRAM to function normally. Assays suitable for detecting the state of phosphorylation of TRAM have utility in identifying compounds which have activity in modulating TRAM. Further disclosed are compounds which have utility in modulating the phosphorylation of TRAM to modulate signalling mediating by the Toll Like Receptor 4 (TLR4) receptor.

Abstract: The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a Toll-like Receptor 9 antagonist sufficient to prevent the activation of Toll-like Receptor 9 by fetal DNA. The invention further provides compositions comprising a Toll-like Receptor 9 antagonist for use in the methods of the invention. Said compositions and methods enhance gestation and therefore improve neonatal morbidity and mortality.

Abstract: The invention relates to a method for heat sealing a lidstock to a container for a blister package, the container having a top surface comprising a substantially flat sealing flange surrounding a blister and a lip having at least one raised surface, the method comprising the steps of a) locating the lidstock on the top surface; b) providing a first seal between the lidstock and the at least one raised surface of the lip with a first heat sealing tool; c) providing a second hermetic seal between the lidstock and the sealing flange surrounding the blister with a second heat sealing tool. The invention also relates to a package for storing a hydrophilic contact lens comprising a lip having at least one raised surface and a removable lidstock sealed to a sealing flange and to the at least one raised surface. Also disclosed is an apparatus for heat sealing the lidstock to the container.

Abstract: The present invention relates to compositions and methods for use in the treatment of conditions such as septicaemia and septic shock. The invention further provides compositions and methods for the suppression Toll-like Receptor 4 mediated activation of the immune system. The invention further provides screening assays to identify compounds which have utility in the foregoing compositions and methods.

Abstract: The invention relates to a method for heat sealing a lidstock (9) to a container (1) for a blister package, the container having a top surface comprising a substantially flat sealing flange (3) surrounding a blister (2) and a lip (4) having at least one raised surface (6), the method comprising the steps of a) locating the lidstock on the top surface; b) providing a first seal between the lidstock and the at least one raised surface of the lip with a first heat sealing tool (11); c) providing a second hermetic seal between the lidstock and the sealing flange surrounding the blister with a second heat sealing tool. The invention also relates to a package for storing a hydrophilic contact lens comprising a lip having at least one raised surface and a removable lidstock sealed to a sealing flange and to the at least one raised surface. Also disclosed is an apparatus for heat sealing the lidstock to the container.

Abstract: Disclosed are assays for the determination and quantification of the phosphorylation of TRAM (Trif-related adaptor molecule). TRAM is rapidly phosphorylated upon LPS stimulation by protein kinase C epsilon (PKC?) and that this phosphorylation is vital for TRAM to function normally. Assays suitable for detecting the state of phosphorylation of TRAM have utility in identifying compounds which have activity in modulating TRAM. Further disclosed are compounds which have utility in modulating the phosphorylation of TRAM to modulate signalling mediating by the Toll Like Receptor 4 (TLR4) receptor.

Abstract: The invention relates to a method for heat sealing a lidstock (9) to a container (1) for a blister package, the container having a top surface comprising a substantially flat sealing flange (3) surrounding a blister (2) and a lip (4) having at least one raised surface (6), the method comprising the steps of a) locating the lidstock on the top surface; b) providing a first seal between the lidstock and the at least one raised surface of the lip with a first heat sealing tool (11); c) providing a second hermetic seal between the lidstock and the sealing flange surrounding the blister with a second heat sealing tool. The invention also relates to a package for storing a hydrophilic contact lens comprising a lip having at least one raised surface and a removable lidstock sealed to a sealing flange and to the at least one raised surface. Also disclosed is an apparatus for heat sealing the lidstock to the container.

Abstract: A method for one-way coupling an input signal to an integrated circuit on a semiconductor chip with the integrated circuit electrically isolated from the input signal comprises forming a MOS isolation coupler on the semiconductor chip by a CMOS process. The MOS isolation coupler comprises an inductor coil for generating a magnetic field in response to an input signal applied to terminals thereof. A MAGFET having a split drain formed by respective drain portions is formed on the semiconductor chip below the inductor coil, so that a current difference is induced between the drain currents in the drain portions which is proportional to the strength of the magnetic field generated by the inductor coil resulting from the input signal. The MAGFET is formed prior to the inductor coil. An oxide isolating layer is provided over the MAGFET, and the inductor coil is formed on the oxide layer.

Abstract: A network node in a communications network collects communication information. The network node collects, when an attempt is made to establish a network connection between a source and a destination, information related to the network connection and either or both of the source and the destination. A report is generated based on the information and at least a portion of the report is forwarded to a user. The report includes information for established network connections and information for unsuccessful attempts to establish network connections.

Abstract: The present invention relates to a service for providing call reports to a subscriber related to non-answered calls for calls attempted between at least two parties. Using telecommunications switch triggers, call status related to answered, busy, and unanswered calls is collected in a record and used to populate a report. The report is then provided to a report formatter that formats the report so that it is suitable for presentation to a subscriber. The reported call information can be provided to the report formatter in near real time.

Abstract: A MOS isolation coupler is formed on a semiconductor chip by a CMOS process and comprises an inductor coil for generating a magnetic field in response to an input signal applied to terminals thereof. A MAGFET having a split drain formed by respective drain portions is formed on the semiconductor chip below the inductor coil, so that a current difference is induced between the drain currents in the drain portions which is proportional to the strength of the magnetic field generated by the inductor coil resulting from the input signal. The MAGFET is formed prior to the inductor coil. An oxide isolating layer is provided over the MAGFET, and the inductor coil is formed on the oxide layer.

Abstract: The present invention relates to a service for providing call reports to a subscriber related to non-answered calls for calls attempted between at least two parties. Using telecommunications switch triggers, call status related to answered, busy, and unanswered calls is collected in a record and used to populate a report. The report is then provided to a report formatter that formats the report so that it is suitable for presentation to a subscriber. The reported call information can be provided to the report formatter in near real time.