Patents by Inventor Anthony P. Adamis

Anthony P. Adamis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF OCULAR DISORDERS
    Publication number: 20170354671
    Abstract: The invention includes a method of treating an intraocular disorder in a mammal, the method comprising administering to the mammal a Very Late Antigen-4 (VLA-4) antagonist for the treatment of selected ocular disorders.
    Type: Application
    Filed: January 25, 2017
    Publication date: December 14, 2017
    Inventors: Eirini Iliaki, Anthony P. Adamis, Joan W. Miller, Evangelos S. Gragoudas
  • Treatment of ocular disorders
    Patent number: 9572829
    Abstract: The invention includes a method of treating an intraocular disorder in a mammal, the method comprising administering to the mammal a Very Late Antigen-4 (VLA-4) antagonist for the treatment of selected ocular disorders.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: February 21, 2017
    Assignee: Massachusetts Eye & Ear Infirmary
    Inventors: Eirini Iliaki, Anthony P. Adamis, Joan W. Miller, Evangelos S. Gragoudas
  • Drug Delivery Systems and Use Thereof
    Publication number: 20160143844
    Abstract: The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to an eye for the treatment of an ocular disorder, for example, age-related macular degeneration.
    Type: Application
    Filed: August 20, 2015
    Publication date: May 26, 2016
    Inventors: Karen G. Carrasquillo, Anthony P. Adamis, Joan W. Miller, Evangelos S. Gragoudas
  • TREATMENT OF OCULAR DISORDERS
    Publication number: 20160000817
    Abstract: The invention includes a method of treating an intraocular disorder in a mammal, the method comprising administering to the mammal a Very Late Antigen-4 (VLA-4) antagonist for the treatment of selected ocular disorders.
    Type: Application
    Filed: March 20, 2015
    Publication date: January 7, 2016
    Inventors: Eirini Iliaki, Anthony P. Adamis, Joan W. Miller, Evangelos S. Gragoudas
  • COMBINATION THERAPY FOR THE TREATMENT OF OCULAR NEOVASCULAR DISORDERS
    Publication number: 20150202289
    Abstract: The invention features methods for treating a patient diagnosed with, or at risk of developing, a neovascular disorder by administering a PDGF antagonist and a VEGF antagonist to the patient. The invention also features a pharmaceutical composition containing a PDGF antagonist and a VEGF antagonist for the treatment or prevention of a neovascular disorder.
    Type: Application
    Filed: January 30, 2015
    Publication date: July 23, 2015
    Inventors: David Shima, Perry Calias, Anthony P. Adamis
  • Combination Therapy for the Treatment of Ocular Neovascular Disorders
    Publication number: 20150202288
    Abstract: The invention features methods for treating a patient diagnosed with, or at risk of developing, a neovascular disorder by administering a PDGF antagonist and a VEGF antagonist to the patient. The invention also features a pharmaceutical composition containing a PDGF antagonist and a VEGF antagonist for the treatment or prevention of a neovascular disorder.
    Type: Application
    Filed: January 16, 2015
    Publication date: July 23, 2015
    Inventors: DAVID SHIMA, PERRY CALIAS, ANTHONY P. ADAMIS
  • Treatment of ocular disorders
    Patent number: 8987219
    Abstract: The invention includes a method of treating an intraocular disorder in a mammal, the method comprising administering to the mammal a Very Late Antigen-4 (VLA-4) antagonist for the treatment of selected ocular disorders.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: March 24, 2015
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Eirini Iliaki, Anthony P. Adamis, Joan W. Miller, Evangelos S. Gragoudas
  • Drug Delivery Systems and Use Thereof
    Publication number: 20140328937
    Abstract: The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to an eye for the treatment of an ocular disorder, for example, age-related macular degeneration.
    Type: Application
    Filed: March 5, 2014
    Publication date: November 6, 2014
    Applicant: Massachusetts Eye and Ear Infirmary
    Inventors: Karen G. Carrasquillo, Anthony P. Adamis, Joan W. Miller, Evangelos S. Gragoudas
  • COMBINATION THERAPY FOR THE TREATMENT OF OCULAR NEOVASCULAR DISORDERS
    Publication number: 20140294816
    Abstract: The invention features methods for treating a patient diagnosed with, or at risk of developing, a neovascular disorder by administering a PDGF antagonist and a VEGF antagonist to the patient. The invention also features a pharmaceutical composition containing a PDGF antagonist and a VEGF antagonist for the treatment or prevention of a neovascular disorder.
    Type: Application
    Filed: June 13, 2014
    Publication date: October 2, 2014
    Inventors: David Shima, Perry Calias, Anthony P. Adamis
  • COMBINATION THERAPY FOR THE TREATMENT OF OCULAR NEOVASCULAR DISORDERS
    Publication number: 20140242082
    Abstract: The invention features methods for treating a patient diagnosed with, or at risk of developing, a neovascular disorder by administering a PDGF antagonist and a VEGF antagonist to the patient. The invention also features a pharmaceutical composition containing a PDGF antagonist and a VEGF antagonist for the treatment or prevention of a neovascular disorder.
    Type: Application
    Filed: February 21, 2014
    Publication date: August 28, 2014
    Applicant: Ophthotech Corporation
    Inventors: David Shima, Perry Calias, Anthony P. Adamis
  • Combination therapy for the treatment of ocular neovascular disorders
    Patent number: 8685397
    Abstract: The invention features methods for treating a patient diagnosed with, or at risk of developing, a neovascular disorder by administering a PDGF antagonist and a VEGF antagonist to the patient. The invention also features a pharmaceutical composition containing a PDGF antagonist and a VEGF antagonist for the treatment or prevention of a neovascular disorder.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: April 1, 2014
    Assignee: Ophthotech Corporation
    Inventors: David Shima, Perry Calias, Anthony P. Adamis
  • Drug Delivery Systems and Use Thereof
    Publication number: 20120201859
    Abstract: The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to an eye for the treatment of an ocular disorder, for example, age-related macular degeneration.
    Type: Application
    Filed: September 28, 2011
    Publication date: August 9, 2012
    Inventors: Karen G. Carrasquillo, Anthony P. Adamis, Joan W. Miller, Evangelos S. Gragoudas
  • Combination therapy for the treatment of ocular neovascular disorders
    Patent number: 8206707
    Abstract: The invention features methods for treating a patient diagnosed with, or at risk of developing, a neovascular disorder by administering a PDGF antagonist and a VEGF antagonist to the patient. The invention also features a pharmaceutical composition containing a PDGF antagonist and a VEGF antagonist for the treatment or prevention of a neovascular disorder.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: June 26, 2012
    Assignee: Ophthotech Corporation
    Inventors: David Shima, Perry Calias, Anthony P. Adamis
  • Combination therapy for the treatment of ocular neovascular disorders
    Patent number: 8187597
    Abstract: The invention features methods for treating a patient diagnosed with, or at risk of developing, a neovascular disorder by administering a PDGF antagonist and a VEGF antagonist to the patient. The invention also features a pharmaceutical composition containing a PDGF antagonist and a VEGF antagonist for the treatment or prevention of a neovascular disorder.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: May 29, 2012
    Assignee: Ophthotech Corporation
    Inventors: David Shima, Perry Calias, Anthony P. Adamis
  • Combination Therapy for the Treatment of Ocular Neovascular Disorders
    Publication number: 20110200593
    Abstract: The invention features methods for treating a patient diagnosed with, or at risk of developing, a neovascular disorder by administering a PDGF antagonist and a VEGF antagonist to the patient. The invention also features a pharmaceutical composition containing a PDGF antagonist and a VEGF antagonist for the treatment or prevention of a neovascular disorder.
    Type: Application
    Filed: January 10, 2011
    Publication date: August 18, 2011
    Inventors: David Shima, Perry Calias, Anthony P. Adamis
  • PREVENTION AND TREATMENT OF RETINAL ISCHEMIA AND EDEMA
    Publication number: 20100203061
    Abstract: The present invention relates to methods of treating retinopathy, retinal ischemia and/or retinal edema comprising administering an integrin or integrin subunit antagonist, leukocyte adhesion-inducing cytokine antagonist or growth factor antagonist, a selectin antagonist or adhesion molecule antagonist.
    Type: Application
    Filed: January 8, 2010
    Publication date: August 12, 2010
    Applicant: The Children's Medical Center Corporation
    Inventor: Anthony P. Adamis
  • Drug Delivery Systems and Use Thereof
    Publication number: 20100189801
    Abstract: The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to an eye for the treatment of an ocular disorder, for example, age-related macular degeneration.
    Type: Application
    Filed: April 2, 2010
    Publication date: July 29, 2010
    Inventors: Karen G. Carrasquillo, Anthony P. Adamis, Joan W. Miller, Evangelos S. Gragoudas
  • Combination therapy for the treatment of ocular neovascular disorders
    Patent number: 7759472
    Abstract: The invention features methods for treating a patient diagnosed with, or at risk of developing, a neovascular disorder by administering a PDGF antagonist and a VEGF antagonist to the patient. The invention also features a pharmaceutical composition containing a PDGF antagonist and a VEGF antagonist for the treatment or prevention of a neovascular disorder.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: July 20, 2010
    Assignee: Ophthotech Corporation
    Inventors: David Shima, Perry Calias, Anthony P. Adamis
  • COMBINATION THERAPY FOR THE TREATMENT OF OCULAR NEOVASCULAR DISORDERS
    Publication number: 20100129364
    Abstract: The invention features methods for treating a patient diagnosed with, or at risk of developing, a neovascular disorder by administering a PDGF antagonist and a VEGF antagonist to the patient. The invention also features a pharmaceutical composition containing a PDGF antagonist and a VEGF antagonist for the treatment or prevention of a neovascular disorder.
    Type: Application
    Filed: December 17, 2009
    Publication date: May 27, 2010
    Applicant: Ophthotech Corporation
    Inventors: David Shima, Perry Calias, Anthony P. Adamis
  • COMBINATION THERAPY FOR THE TREATMENT OF OCULAR NEOVASCULAR DISORDERS
    Publication number: 20100119522
    Abstract: The invention features methods for treating a patient diagnosed with, or at risk of developing, a neovascular disorder by administering a PDGF antagonist and a VEGF antagonist to the patient. The invention also features a pharmaceutical composition containing a PDGF antagonist and a VEGF antagonist for the treatment or prevention of a neovascular disorder.
    Type: Application
    Filed: September 22, 2009
    Publication date: May 13, 2010
    Applicant: Ophthotech Corporation
    Inventors: David Shima, Perry Calias, Anthony P. Adamis