Patents by Inventor Anthony Ragheb
Anthony Ragheb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Endoluminal medical device for local delivery of cathepsin inhibitors, method of making and treating
Publication number: 20070293937Abstract: An endoluminal medical device comprises a drug release system that releases a cathepsin inhibitor at a predetermined location within a lumen of a patient. The endoluminal devices and methods of treatment of disease can treat illnesses such as aneurysms and aortic dissections.Type: ApplicationFiled: June 1, 2007Publication date: December 20, 2007Inventors: David Biggs, David Grewe, Neal Fearnot, Patrick Ruane, Anthony Ragheb -
Publication number: 20070282422Abstract: This invention relates to medical devices and an elastin-stabilizing compound, such as a phenolic tannin, the medical device being adapted to release the elastin-stabilizing compound within a body of a patient. This invention also relates to medical devices and methods of treatment of disease, such as aneurysms and aortic dissection. Medical devices may include coated stents, grafts, stent grafts, balloons and catheters.Type: ApplicationFiled: May 4, 2007Publication date: December 6, 2007Inventors: David Biggs, Anthony Ragheb, Patrick Ruane
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Publication number: 20070203520Abstract: Endovascular filter (10) including a plurality of struts (14) with distal ends (18) adapted to anchor the filter to the vessel wall after deployment, such as by having barbs (20), the filter being adapted to be retrieved if desired. Strut distal ends (18) are coated with an antiproliferative agent (40) that inhibits the ingrowth of tissue around the filter, thereby permitting the filter to be retrieved and removed atraumatically after a prolonged period of time, thus extending the useful life of the retrievable filter. Optionally, the proximal end (22) of the filter may also be so coated, or the entire filter.Type: ApplicationFiled: January 16, 2007Publication date: August 30, 2007Inventors: Dennis Griffin, Arne Molgaard-Nielsen, Anthony Ragheb, Raymond Leonard, Neal Fearnot, William Voorhees, Thomas Kozma, Brian Bates, Thomas Osborne
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Publication number: 20070168012Abstract: Methods of making coated implantable medical devices are provided. The methods include positioning a first layer comprising a bioactive on at least a portion of a structure, and positioning at least one porous layer over the first layer. The at least one porous layer has a thickness adequate to provide a controlled release of the bioactive.Type: ApplicationFiled: November 27, 2006Publication date: July 19, 2007Applicants: MED Institute, Inc., Cook IncorporatedInventors: Anthony Ragheb, Brian Bates, Neal Fearnot, Thomas Kozma, William Voorhees
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Publication number: 20070150047Abstract: Methods of making coated implantable medical devices are provided. The methods include positioning a first layer comprising a bioactive on at least a portion of a structure, and positioning at least one porous layer over the first layer. The at least one porous layer has a thickness adequate to provide a controlled release of the bioactive.Type: ApplicationFiled: November 15, 2006Publication date: June 28, 2007Applicants: MED Institute, Inc., Cook IncorporatedInventors: Patrick Ruane, Waleska Perez-Segarra, Anthony Ragheb, Neal Fearnot, William Voorhees, Brian Bates, Thomas Osborne
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Publication number: 20070050010Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.Type: ApplicationFiled: September 1, 2006Publication date: March 1, 2007Applicants: Cook Incorporated, MED Institute, Inc.Inventors: Brian Bates, Anthony Ragheb, Neal Fearnot, William Voorhees, Thomas Kozma, David Grewe, Darin Schaeffer
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Publication number: 20060206187Abstract: A stent delivery system includes at least one stent and a holder. The stent is expandable from a compressed state to an expanded state. The holder is configured to interfere or interlock with the stent. The holder may be blowmolded onto an inner surface of the compressed stent. An outer diameter of the holder is approximately the same as an inner diameter of the stent.Type: ApplicationFiled: March 9, 2005Publication date: September 14, 2006Inventors: Fred Parker, Anthony Ragheb
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Publication number: 20060195176Abstract: Bioactive-coated medical devices are provided, including coated vascular stents. The medical device coating can include a coating layer posited over at least a portion of the medical device surface, and can include a butyl methacrylate polymer or an ethylene-vinyl acetate copolymer in combination with a bioactive material that can function as both an immunosuppressive agent and an antiproliferative agent. Optionally, multilayer coatings can further include an adhesion promoting layer comprising parylene positioned between the coating layer and the medical device surface, a porous layer comprising butyl methacrylate positioned over at least a portion of the coating layer, or both. The coating layer preferably comprises between about 0.5 and 2.0 ?g/mm2 of the bioactive material on the outer surface of the medical device. The bioactive material can be absorbed into the coating layer, which can have a thickness of between about 0.5 ?m to about 5 ?m.Type: ApplicationFiled: April 25, 2006Publication date: August 31, 2006Applicants: Cook Incorporated, MED Institute, Inc.Inventors: Brian Bates, Anthony Ragheb, Neal Fearnot, Thomas Kozma, William Voorhees
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Publication number: 20060020331Abstract: A coated medical device adapted for introduction into a passage or vessel of a patient is provided. The medical device is preferably an implantable balloon with a bioactive deposited or within the balloon. The balloon can further include a hydrophilic material positioned between the balloon and a bioactive material posited on the balloon.Type: ApplicationFiled: September 23, 2005Publication date: January 26, 2006Applicant: Cook IncorporatedInventors: Brian Bates, Scott Boatman, David Burton, Michael Hoffa, Darin Schaeffer, Jason Sturgeon, Anthony Ragheb
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Publication number: 20050278021Abstract: A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.Type: ApplicationFiled: May 31, 2005Publication date: December 15, 2005Applicants: MED INSTITUTE, INC., COOK INCORPORATEDInventors: Brian Bates, Anthony Ragheb, Joseph Stewart, William Bourdeau, Brian Choules, James Purdy, Neal Fearnot
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Publication number: 20050222677Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.Type: ApplicationFiled: May 25, 2005Publication date: October 6, 2005Inventors: Brian Bates, Anthony Ragheb, Neil Fearnot, Thomas Kozma, William Voorhees