Patents by Inventor Anthony Treston

Anthony Treston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Iminosugars useful for the treatment of viral diseases
    Patent number: 10428022
    Abstract: Formula IA, and their use for treating viral infections.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: October 1, 2019
    Assignee: Emergent Virology LLC
    Inventors: Urban Ramstedt, Kelly Lyn Warfield, Anthony Treston
  • IMINOSUGARS USEFUL FOR THE TREATMENT OF VIRAL DISEASES
    Publication number: 20180273473
    Abstract: Formula IA, and their use for treating viral infections.
    Type: Application
    Filed: November 4, 2015
    Publication date: September 27, 2018
    Inventors: Urban RAMSTEDT, Kelly Lyn WARFIELD, Anthony TRESTON
  • Synthesis of 4-amino-thalidomide enantiomers
    Patent number: 8153806
    Abstract: The invention provides new and useful analogs of 4-amino-thalidomide. These analogs include S(?)-4-amino-thalidomide and R(+)-4-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: April 10, 2012
    Assignee: The Children's Medical Center Corporation
    Inventors: Anthony Treston, Jamshed H. Shah, Robert J. D'Amato, Kimberly A. Hunsucker, John Rougas, Barry P. Conner, Victor Pribdula, Glenn M. Swartz
  • SYNTHESIS OF 4-AMINO-THALIDOMIDE ENANTIOMERS
    Publication number: 20100280249
    Abstract: The invention provides new and useful analogs of 4-amino-thalidomide. These analogs include S(?)-4-amino-thalidomide and R(+)-4-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.
    Type: Application
    Filed: July 16, 2010
    Publication date: November 4, 2010
    Inventors: Anthony Treston, Jamshed H. Shah, Robert J. D'Amato, Kimberly A. Hunsucker, John Rougas, Barry P. Conner, Victor Pribdula, Glenn M. Swartz
  • Method of synthesis of 4-amino-thalidomide enantiomers
    Patent number: 7812169
    Abstract: The invention provides new and useful analogs of 4-amino-thalidomide. These analogs include S(?)-4-amino-thalidomide and R(+)-4-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: October 12, 2010
    Assignee: The Children's Medical Center Corporation
    Inventors: Anthony Treston, Jamshed H. Shah, Robert J. D'Amato, Kimberly A. Hunsucker, John Rougas, Barry P. Conner, Victor Pribdula, Glenn M. Swartz
  • Methods for treating macular degeneration using 4-(amino)-2-(2,6-dioxo(3-piperidyle))-isoindoline-1,3-dione
    Publication number: 20080306113
    Abstract: Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione, or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, alone or in combination with a second active agent and/or surgery.
    Type: Application
    Filed: April 22, 2008
    Publication date: December 11, 2008
    Inventors: Anthony Treston, Jamshed H. Shah, Robert J. D'Amato, Kimberly A. Hunsucker, John Rougas, Barry P. Conner, Victor Pribdula, Glenn M. Swartz
  • Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents
    Publication number: 20070185069
    Abstract: The present invention relates generally to methods and compositions of treating disease characterized by abnormal cell proliferation and/or abnormal or undesirable angiogenesis by administering antiangiogenic agents in combination with chemotherapeutic agents. More specifically, the present invention relates to a methods and compositions of treating diseases characterized by abnormal cell proliferation and/or abnormal or undesirable angiogenesis by administering 2-methoxyestradiol, in combination with chemotherapeutic agents.
    Type: Application
    Filed: November 14, 2006
    Publication date: August 9, 2007
    Inventors: Stacy Plum, Steven Strawn, Theresa LaVallee, Carolyn Sidor, William Fogler, Anthony Treston
  • Substituted pyrazole compounds
    Publication number: 20070142368
    Abstract: Disclosed are protein kinase inhibitors, compositions comprising such inhibitors, and methods of use thereof. More particularly, disclosed are inhibitors of Aurora A (Aurora-2) protein kinase. Also disclosed are methods of treating diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.
    Type: Application
    Filed: September 29, 2006
    Publication date: June 21, 2007
    Inventors: Xiao-Yi Xiao, Dinish Patel, John Ward, Mark Bray, Gregory Agoston, Anthony Treston
  • Estradiol derivatives
    Publication number: 20070135400
    Abstract: Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification.
    Type: Application
    Filed: February 2, 2007
    Publication date: June 14, 2007
    Inventors: Gregory Agoston, Theresa LaVallee, Victor Pribluda, Jamshed Shah, Anthony Treston
  • Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs
    Publication number: 20070105903
    Abstract: The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, nitrogen-substituted thalidomide analogs and di-substituted thalidomide analogs have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.
    Type: Application
    Filed: August 29, 2006
    Publication date: May 10, 2007
    Inventors: Anthony Treston, Jamshed Shah, Robert D'Amato, Barry Conner, Kimberly Hunsucker, John Rougas, Glenn Swartz, Victor Pribluda
  • Methods of treating disease states using antiangiogenic agents
    Publication number: 20070010505
    Abstract: Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification.
    Type: Application
    Filed: September 12, 2006
    Publication date: January 11, 2007
    Inventors: Gregory Agoston, Theresa LaVallee, Victor Pribluda, Jamshed Shah, Anthony Treston
  • Antiangiogenic agents
    Publication number: 20070004689
    Abstract: Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ra is selected from —OCH3, —OCH2CH3 or —CCCH3; and Z is selected from >C(H)—OH, >C(H)—O-alkyl, >C(H)—O-sulfamate, or >C(H)-dioxolane, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.
    Type: Application
    Filed: July 19, 2006
    Publication date: January 4, 2007
    Inventors: Gregory Agoston, Jamshed Shah, Lita Suwandi, Theresa LaVallee, Anthony Treston
  • Use of nitrogen substituted thalidomide analogs for the treatment of macular degenerator
    Patent number: 7153867
    Abstract: The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, nitrogen-substituted thalidomide analogs and di-substituted thalidomide analogs have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: December 26, 2006
    Assignee: Celgene Corporation
    Inventors: Jamshed H. Shah, Barry P. Conner, Glenn M. Swartz, Kimberly A. Hunsucker, John Rougas, Robert J. D'Amato, Victor Pribluda, Anthony Treston
  • Antiangiogenic agents
    Publication number: 20060135796
    Abstract: Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula: wherein the variables are defined in the specification.
    Type: Application
    Filed: February 6, 2006
    Publication date: June 22, 2006
    Inventors: Gregory Agoston, Victor Pribluda, Anthony Treston, Shawn Green
  • Method of administering anti-angiogenic agents and a method of treating disease using same
    Publication number: 20060116360
    Abstract: A method of administering an anti-angiogenic agent to a human or an animal comprising administering the anti-angiogenic agent such that a plasma concentration of the anti-angiogenic agent in the human or animal is substantially continuously maintained above 1 ng/mL.
    Type: Application
    Filed: November 29, 2005
    Publication date: June 1, 2006
    Inventors: William Fogler, Carolyn Sidor, Anthony Treston, Kirk Volker
  • Compositions and methods comprising proteinase activated receptor antagonists
    Publication number: 20060063930
    Abstract: Compositions and methods comprising proteinase activated receptor antagonists are provided. More particularly, the present invention relates to the use of proteins, peptides and molecules that bind to proteinase activated receptor 2, and inhibit the processes associated with the activation of that receptor. More specifically, the present invention provides novel compositions and methods for the treatment of disorders and diseases such as those associated with abnormal cellular proliferation, angiogenesis, inflammation and cancer.
    Type: Application
    Filed: August 19, 2005
    Publication date: March 23, 2006
    Inventors: Gregory Agoston, Todd Hembrough, Theresa LaVallee, Jamshed Shah, Lita Suwandi, Anthony Treston
  • Methods of using 2-methoxyestradiol of high purity
    Publication number: 20060025619
    Abstract: 2-methoxyestradiol having greater than 98% purity is obtained by synthetic or purification methods. This highly pure 2-methoxy estradiol, lacking estrogenic components, is particularly suitable for clinical use in humans. The purification methods of the invention involve the use of liquid-solid chromatography (LSC) to separate 2-ME2 from other compounds. The chromatographic media is preferably silica. The solvent system comprises a non-polar solvent, such as chloroform, and a polar solvent, such as methanol.
    Type: Application
    Filed: September 26, 2005
    Publication date: February 2, 2006
    Inventors: Gregory Agoston, Jamshed Shah, Anthony Treston
  • Antiangiogenic agents
    Publication number: 20050203075
    Abstract: Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ra is selected from —OCH3, —OCH2CH3 or —CCCH3; and Z is selected from >C(H)—OH, >C(H)—O-alkyl, >C(H)—O-sulfamate, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.
    Type: Application
    Filed: March 11, 2005
    Publication date: September 15, 2005
    Inventors: Gregory Agoston, Jamshed Shah, Lita Suwandi, Theresa LaVallee, Anthony Treston
  • Antiangiogenic agents
    Publication number: 20050192258
    Abstract: Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula: wherein the variables are defined in the specification.
    Type: Application
    Filed: April 29, 2005
    Publication date: September 1, 2005
    Inventors: Gregory Agoston, Jamshed Shah, Kimberly Hunsucker, Victor Pribluda, Theresa LaVallee, Shawn Green, Christopher Herbstritt, Xiaoguo Zhan, Anthony Treston
  • Antiangiogenic agents
    Publication number: 20050014737
    Abstract: Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification.
    Type: Application
    Filed: May 28, 2004
    Publication date: January 20, 2005
    Inventors: Gregory Agoston, Theresa LaVallee, Victor Pribluda, Jamshed Shah, Anthony Treston