Patents by Inventor Antonino Cattaneo

Antonino Cattaneo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTRABODIES TARGETING POST-TRANSLATIONAL MODIFICATIONS OF NATIVE PROTEINS AND METHOD FOR OBTAINING THEM
    Publication number: 20220065850
    Abstract: The present invention refers to a method for determining the ability of an immunoglobulin to bind to a post-translationally modified target in an intracellular environment, which folds and it is post-translationally modified as a native protein intracellularly. The present invention also refers to antibodies obtained by the above method and uses thereof.
    Type: Application
    Filed: September 13, 2021
    Publication date: March 3, 2022
    Applicant: SCUOLA NORMALE SUPERIORE
    Inventors: Antonino CATTANEO, Michele CHIRICHELLA
  • Intrabodies targeting post-translational modifications of native proteins and method for obtaining them
    Patent number: 11137393
    Abstract: The present invention refers to a method for determining the ability of an immunoglobulin to bind to a post-translationally modified target in an intracellular environment, which folds and it is post-translationally modified as a native protein intracellularly. The present invention also refers to antibodies obtained by the above method and uses thereof.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: October 5, 2021
    Assignee: SCUOLA NORMALE SUPERIORE
    Inventors: Antonino Cattaneo, Michele Chirichella
  • INHIBITOR OF ASTROCYTE TNF ALPHA FOR USE IN THE TREATMENT OF NEUROLOGICAL DISEASES
    Publication number: 20200339647
    Abstract: Disclosed is a human mutated form of NGF including two mutations, a first mutation being represented by the substitution of the proline amino acid in position 61 with a serine, a second mutation being represented by the substitution of an amino acid in any one of the positions 95-101, for simultaneous use as agent for the activation of the chemokine SDF-1alpha and as agent for the inhibition of the activity of the cytokine TNF alpha.
    Type: Application
    Filed: July 14, 2020
    Publication date: October 29, 2020
    Inventor: Antonino CATTANEO
  • INTRABODIES TARGETING POST-TRANSLATIONAL MODIFICATIONS OF NATIVE PROTEINS AND METHOD FOR OBTAINING THEM
    Publication number: 20190361013
    Abstract: The present invention refers to a method for determining the ability of an immunoglobulin to bind to a post-translationally modified target in an intracellular environment, which folds and it is post-translationally modified as a native protein intracellularly. The present invention also refers to antibodies obtained by the above method and uses thereof.
    Type: Application
    Filed: November 2, 2016
    Publication date: November 28, 2019
    Inventors: Antonino CATTANEO, Michele CHIRICHELLA
  • INHIBITOR OF ASTROCYTE TNF ALPHA FOR USE IN THE TREATMENT OF NEUROLOGICAL DISEASES
    Publication number: 20190092825
    Abstract: Disclosed is a human mutated form of NGF including two mutations, a first mutation being represented by the substitution of the proline amino acid in position 61 with a serine, a second mutation being represented by the substitution of an amino acid in any one of the positions 95-101, for simultaneous use as agent for the activation of the chemokine SDF-1alpha and as agent for the inhibition of the activity of the cytokine TNF alpha.
    Type: Application
    Filed: March 3, 2017
    Publication date: March 28, 2019
    Inventor: Antonino CATTANEO
  • proNGF mutants and uses thereof for the preparation of NGF mutants
    Publication number: 20180086805
    Abstract: Pro-NGF—Nerve Growth Factor—mutants and their uses for the production of NGF mutants are disclosed. Also disclosed are useful new process to optimize and improve the purification of NGF P61SR100E, a therapeutic protein. The invention further provides a mutant pro-NGF wherein the protease cleavage site RASKRB is substituted at least at position RA and K by a non-basic amino acid, and the mutant pro-NGF further includes at least one mutation selected from P165S or R204E.
    Type: Application
    Filed: May 12, 2017
    Publication date: March 29, 2018
    Inventors: Antonino CATTANEO, Francesca MALERBA
  • Molecules that are able to inhibit the binding between NGF and the TrkA receptor as analgesics with prolonged effect
    Patent number: 9688749
    Abstract: Use of an anti-NGF antibody capable of inhibiting the binding between NGF and TrkA, capable of blocking the biological activity of TrkA for the preparation of a medicament for treating and/or preventing chronic pain.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: June 27, 2017
    Assignee: AbbVie Inc.
    Inventors: Flaminia Pavone, Sara Martinelli, Antonino Cattaneo, Gabriele Ugolini
  • METHODS FOR THE HUMANIZATION OF ANTIBODIES AND HUMANIZED ANTIBODIES THEREBY OBTAINED
    Publication number: 20150218264
    Abstract: Method for the humanization of the VH and VL variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-NGF and anti-TrkA humanized animal antibodies.
    Type: Application
    Filed: November 4, 2014
    Publication date: August 6, 2015
    Inventors: Antonino Cattaneo, Doriano Lamba, Sonia Covaceuszach
  • Polynucleotides encoding humanized anti-NGF antibodies
    Patent number: 8877491
    Abstract: Method for the humanization of the VH and VL variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-NGF and anti-TrkA humanized animal antibodies.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: November 4, 2014
    Assignee: Abbvie Inc.
    Inventors: Antonino Cattaneo, Doriano Lamba, Sonia Covaceuszach
  • METHOD FOR THE HUMANIZATION OF ANTIBODIES AND HUMANIZED ANTIBODIES THEREBY OBTAINED
    Publication number: 20140316113
    Abstract: Method for the humanization of the VH and VL variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-NGF and anti-TrkA humanized animal antibodies.
    Type: Application
    Filed: March 17, 2014
    Publication date: October 23, 2014
    Applicants: Lay Line Genomics S.p.A., Scuola Internazionale Superiore di Studi Avanzati
    Inventors: Antonino Cattaneo, Doriano Lamba, Sonia Covaceuszach
  • Method for the humanization of antibodies and humanized antibodies thereby obtained
    Patent number: 8296079
    Abstract: Method for the humanization of the VH and VL variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-NGF and anti-TrkA humanized animal antibodies.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: October 23, 2012
    Assignees: Scoula Internazionale Superiore di Studi Avanzati, Pangenetics B.V.
    Inventors: Antonino Cattaneo, Sonia Covaceuszach, Doriano Lamba
  • Method for the treatment of pain with humanized anti-nerve growth factor antibodies
    Patent number: 8257710
    Abstract: Method for the humanization of the VH and VL variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-NGF and anti-TrkA humanized animal antibodies.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: September 4, 2012
    Assignee: Abbott Research, B.V.
    Inventors: Antonino Cattaneo, Doriano Lamba, Sonia Covaceuszach
  • Humanized anti-nerve growth factor antibodies
    Patent number: 8246956
    Abstract: Method for the humanization of the VH and VL variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-NGF and anti-TrkA humanized animal antibodies.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: August 21, 2012
    Assignee: Abbott Research B.V.
    Inventors: Antonino Cattaneo, Doriano Lamba, Sonia Covaceuszach
  • METHOD FOR THE HUMANIZATION OF ANTIBODIES AND HUMANIZED ANTIBODIES THEREBY OBTAINED
    Publication number: 20110191872
    Abstract: Method for the humanization of the VH and VL variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-NGF and anti-TrkA humanized animal antibodies.
    Type: Application
    Filed: July 16, 2010
    Publication date: August 4, 2011
    Inventors: Antonino CATTANEO, Doriano LAMBA, Sonia COVACEUSZACH
  • Method for the potentiation of opioid analgesics effects on pain
    Patent number: 7988966
    Abstract: According to the invention there is provided use of an anti-TrkA antibody capable of inhibiting the binding between NGF and TrkA combined with at least one opioid analgesic for the preparation of a medicament for treating and/or preventing pain.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: August 2, 2011
    Assignee: Lay Line Genomics S.p.A.
    Inventors: Flaminia Pavone, Sara Marinelli, Antonino Cattaneo, Gabriele Ugolini
  • METHOD FOR THE HUMANIZATION OF ANTIBODIES AND HUMANIZED ANTIBODIES THEREBY OBTAINED
    Publication number: 20110105728
    Abstract: Method for the humanization of the VH and VL variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-NGF and anti-TrkA humanized animal antibodies.
    Type: Application
    Filed: July 16, 2010
    Publication date: May 5, 2011
    Inventors: Antonino CATTANEO, Doriano LAMBA, Sonia COVACEUSZACH
  • METHOD FOR THE HUMANIZATION OF ANTIBODIES AND HUMANIZED ANTIBODIES THEREBY OBTAINED
    Publication number: 20110104164
    Abstract: Method for the humanization of the VH and VL variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-NGF and anti-TrkA humanized animal antibodies.
    Type: Application
    Filed: July 16, 2010
    Publication date: May 5, 2011
    Inventors: Antonino CATTANEO, Doriano LAMBA, Sonia COVACEUSZACH
  • Method for the humanization of antibodies and humanized antibodies thereby obtained
    Publication number: 20110105727
    Abstract: Method for the humanization of the VII and VL variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-NGF and anti-TrkA humanized animal antibodies.
    Type: Application
    Filed: July 9, 2010
    Publication date: May 5, 2011
    Applicants: LAY LINE GENOMICS S.p.A., Scuola Internazionale Superiore di Studi Avanzati
    Inventors: Antonino Cattaneo, Doriano Lamba, Sonia Covaceuszach
  • Selection of intracellular immunoglobulins
    Patent number: 7897347
    Abstract: A general immunoglobulin-target assay system is provided, in which a positive outcome (the generation of a signal) depends only on the intracellular interaction of immunoglobulin with target. This can be accomplished for many immunoglobulins expressed in yeast and/or in mammalian cells and allows the selection of immunoglobulins which are capable of functioning in an intracellular environment.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: March 1, 2011
    Assignees: Medical Research Council, Scuola Internazionale Superiore di Studi Avanzati
    Inventors: Wai-Choi Eric Tse, Terence Rabbits, Antonino Cattaneo, Michela Visintin
  • SELECTION OF INTRACELLULAR IMMUNOGLOBULINS
    Publication number: 20090317822
    Abstract: A general immunoglobulin-target assay system is provided, in which a positive outcome (the generation of a signal) depends only on the intracellular interaction of immunoglobulin with target. This can be accomplished for many immunoglobulins expressed in yeast and/or in mammalian cells and allows the selection of immunoglobulins which are capable of functioning in an intracellular environment.
    Type: Application
    Filed: July 31, 2009
    Publication date: December 24, 2009
    Applicants: MEDICAL RESEARCH COUNCIL, SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI
    Inventors: Wai-Choi Eric TSE, Terence RABBITS, Antonino CATTANEO, Michela VISINTIN