Patents by Inventor Antonio Guarna

Antonio Guarna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6,8-dioxa-3-azabicyclo[3.2.l]Octane Carboxylic Acids And Their Derivatives For Use In The Treatment Of Inflammations
    Publication number: 20230165870
    Abstract: The present invention describes 3-aza-bicyclo[3.2.1]octane acids of general formula (I), their Salts and Esters, for use as activators of ADAR1 in the treatment of diseases related to acute or chronic inflammations, infective or not., characterized by cytokine storm and/or uncontrolled immune response.
    Type: Application
    Filed: April 14, 2021
    Publication date: June 1, 2023
    Applicants: MINERVA S.R.L., MIMETECH S.R.L.
    Inventors: Antonio GUARNA, Giuseppe CASTRONOVO, Michele TANTURLI
  • COMPOUNDS FOR THE TREATMENT OF ISCHEMIA-REPERFUSION-RELATED DISEASES
    Publication number: 20180155363
    Abstract: The present invention relates to compounds of formula (I) useful in the treatment of ischemia-reperfusion-related pathologies.
    Type: Application
    Filed: December 12, 2017
    Publication date: June 7, 2018
    Inventors: Antonio Guarna, Federico Cozzolino
  • Compounds for the treatment of ischemia-reperfusion-related diseases
    Patent number: 9932352
    Abstract: The present invention relates to compounds of formula (I) useful in the treatment of ischemia-reperfusion-related pathologies.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: April 3, 2018
    Assignee: MINERVA PATENTS S.A.
    Inventors: Antonio Guarna, Federico Cozzolino
  • COMPOUNDS FOR THE TREATMENT OF ISCHEMIA-REPERFUSION-RELATED DISEASES
    Publication number: 20150080388
    Abstract: The present invention relates to compounds of formula (I) useful in the treatment of ischemia-reperfusion-related pathologies.
    Type: Application
    Filed: March 20, 2013
    Publication date: March 19, 2015
    Inventors: Antonio Guarna, Federico Cozzolino
  • Preparation of conjugates comprising adenine derivatives and allergenic proteins and their use for specific immunotherapy of allengenic diseases
    Patent number: 8822407
    Abstract: The present invention refers to the preparation of adenine derivative active esters of formula (I) and use thereof for the preparation of stable conjugates between adenine derivative and allergenic proteins having general structure (II) for the modulation of TH2 response in allergic diseases. (I, II).
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: September 2, 2014
    Assignee: Universita' Degli Studi di Firenze
    Inventors: Sergio Romagnani, Enrico Maggi, Paola Parronchi, Antonio Guarna, Ernesto Giovanni Occhiato
  • 1,2,3-triazole-based peptidomimetic integrin inhibitors for the diagnosis and therapy of tumors
    Patent number: 8809338
    Abstract: The present invention refers to the field of chemical compounds bearing a 1,2,3-triazole ring of formula (I) and possessing guanidino and carboxylic groups or their isosteres, their preparation by Cu-catalyzed “click-chemistry”, and medical-diagnostic use in pathologies where angiogenesis is altered, for example pathologic conditions of tumor origin, tumor metastasis, osteoporosis, and rheumatoid arthritis.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: August 19, 2014
    Assignee: Universita' Degli Studi di Firenze
    Inventors: Antonio Guarna, Gloria Menchi, Nicoletta Cini, Andrea Trabocchi, Alberto Pupi, Anna Bottoncetti, Silvia Raspanti, Lido Calorini
  • PREPARATION OF CONJUGATES COMPRISING ADENINE DERIVATIVES AND ALLERGENIC PROTEINS AND THEIR USE FOR SPECIFIC IMMUNOTHERAPY OF ALLENGENIC DISEASES
    Publication number: 20130136764
    Abstract: The present invention refers to the preparation of adenine derivative active esters of formula (I) and use thereof for the preparation of stable conjugates between adenine derivative and allergenic proteins having general structure (II) for the modulation of TH2 response in allergic diseases.(I, II).
    Type: Application
    Filed: August 4, 2011
    Publication date: May 30, 2013
    Applicant: UNIVERSITA ' DEGLI STUDI DI FIRENZE
    Inventors: Sergio Romagnani, Enrico Maggi, Paola Parronchi, Antonio Guarna, Ernesto Giovanni Occhiato
  • Bicyclic peptidomimetic inhibitors of aspartyl-proteases for the treatment of infectious diseases
    Patent number: 8445484
    Abstract: The present invention refers to 3-aza-bicyclo [3.2.1] octane derivatives of general formula (I) their preparation, use and pharmaceutical compositions useful in the treatment of pathologies associated with microbial pathogens expressing aspartylprotease activity.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: May 21, 2013
    Assignees: Istituto Superiore di Sanita', Universita' Degli Studi di Firenze
    Inventors: Antonio Cassone, Flavia De Bernardis, Enrico Garaci, Andrea Trabocchi, Antonio Guarna
  • 1,2,3-TRIAZOLE-BASED PEPTIDOMIMETIC INTEGRIN INHIBITORS FOR THE DIAGNOSIS AND THERAPY OF TUMORS
    Publication number: 20130040964
    Abstract: The present invention refers to the field of chemical compounds bearing a 1,2,3-triazole ring of formula (I) and possessing guanidino and carboxylic groups or their isosteres, their preparation by Cu-catalyzed “click-chemistry”, and medical-diagnostic use in pathologies where angiogenesis is altered, for example pathologic conditions of tumor origin, tumor metastasis, osteoporosis, and rheumatoid arthritis.
    Type: Application
    Filed: February 14, 2011
    Publication date: February 14, 2013
    Applicant: UNIVERSITA' DEGLI STUDI DI FIRENZE
    Inventors: Antonio Guarna, Gloria Menchi, Nicoletta Cini, Andrea Trabocchi, Alberto Pupi, Anna Bottoncetti, Silvia Raspanti, Lido Calorini
  • Process for the preparation of 2,3,4,9-tetrahydro-1H-?-carbolin-3-carboxylic acid esters
    Patent number: 8357803
    Abstract: The present invention relates to the process of preparation of 2,3,4,9-tetrahydro-1/?/-?-carbolin-3-carboxylic acid esters substituted in position 1 of the general formula (I). in the preferred diastereoisomeric form through a single step starting from tryptophan in racemic form and/or its enantiomers and from 3,4-(methylenedioxy)benzaldehyde.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: January 22, 2013
    Assignee: Endura S.p.A.
    Inventors: Valerio Borzatta, Dina Scarpi, Antonio Guarna, Ernesto G. Occhiato
  • BICYCLIC PEPTIDOMIMETIC INHIBITORS OF ASPARTYL-PROTEASES FOR THE TREATMENT OF INFECTIOUS DISEASES
    Publication number: 20110237577
    Abstract: The present invention refers to 3-aza-bicyclo[3.2.1]octane derivatives of general formula (I) their preparation, use and pharmaceutical compositions useful in the treatment of pathologies associated with microbial pathogens expressing aspartyl-protease activity.
    Type: Application
    Filed: November 24, 2009
    Publication date: September 29, 2011
    Inventors: Antonio Cassone, Flavia De Bernardis, Enrico Garaci, Andrea Trabocchi, Antonio Guarna
  • PROCESS FOR THE PREPARATION OF 2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLIN-3-CARBOXYLIC ACID ESTERS
    Publication number: 20100324294
    Abstract: The present invention relates to the process of preparation of 2,3,4,9-tetrahydro-1/?/-?-carbolin-3-carboxylic acid esters substituted in position 1 of the general formula (I). in the preferred diastereoisomeric form through a single step starting from tryptophan in racemic form and/or its enantiomers and from 3,4-(methylenedioxy)benzaldehyde.
    Type: Application
    Filed: February 20, 2009
    Publication date: December 23, 2010
    Inventors: Valerio Borzatta, Dina Scarpi, Antonio Guarna, Ernesto G. Occhiato
  • HETEROCYLIC COMPOUNDS CONTAINING THE MORPHOLINE NUCLEUS THEIR PREPARATION AND USE
    Publication number: 20100087326
    Abstract: Herein are described heterocyclic compounds containing the morpholine nucleus prepared from amino acids, their preparation and use for therapeutic applications.
    Type: Application
    Filed: April 18, 2008
    Publication date: April 8, 2010
    Inventors: Antonio Guarna, Andrea Trabocchi, Gloria Menchi, Claudia Lalli, Filippo Sladojevich, Nicoletta Cini
  • Pharmaceutical compositions for the treatment of diseases related to neurotrophines
    Patent number: 7625892
    Abstract: The present invention refers to pharmaceutical preparations including as active compounds 3-aza-bicyclo[3.2.1]octane derivatives of general formula (I) and/or their dimers of general formula (II) and (III) acting as agonists of human neurotrophines. Therefore, such compounds of formula (I), (II) and (III) are useful for treatment of diseases in which the neurotrophine functions are involved in defect, particularly of Nerve Growth Factor (NGF), such as neurodegenerative diseases of central nervous system (CNS), acquired immunodeficiency due to a reduced NGF biodisponibility, or morbous conditions in which the stimulus of neoangiogenesis process is convenient.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: December 1, 2009
    Assignee: Mimetech S.r.l.
    Inventors: Antonio Guarna, Federico Cozzolino, Maria Torcia, Enrico Garaci
  • Pharmaceutical compositions for the treatment of diseases related to neurotrophines
    Publication number: 20060069092
    Abstract: The present invention refers to pharmaceutical preparations including as active compounds 3-aza-bicyclo[3.2.1]octane derivatives of general formula (I) and/or their dimers of general formula (II) and (III) acting as agonists of human neurotrophines. Therefore, such compounds of formula (I), (II) and (III) are useful for treatment of diseases in which the neurotrophine functions are involved in defect, particularly of Nerve Growth Factor (NGF), such as neurodegenerative diseases of central nervous system (CNS), acquired immunodeficiency due to a reduced NGF biodisponibility, or morbous conditions in which the stimulus of neoangiogenesis process is convenient.
    Type: Application
    Filed: June 18, 2003
    Publication date: March 30, 2006
    Inventors: Antonio Guarna, Federico Cozzolino, Marcia Torcia, Enrico Garaci
  • Benzo(C)quinolizine derivatives and their use as 5?-reductases inhibitors
    Patent number: 6962925
    Abstract: A fully and partially reduced benzo(c)quinolizine compound of formula (1):
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: November 8, 2005
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Antonio Guarna, Mario Serio
  • Process for the synthesis of (1-H)-benzo[c]quinolizin-3-ones derivatives
    Patent number: 6723850
    Abstract: The present invention refers to a process for the preparation of (1H)-benzo[c]quinolizin-3-ones derivatives of general formula (I) which involves only three steps and the use, as starting products, of commercially available, or easily preparable, compounds. The compounds of formula (I) are useful as inhibitors of 5&agr;-reductases.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: April 20, 2004
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Antonio Guarna, Mario Serio, Ernesto Occhiato
  • 3-aza-6,8-dioxabicyclo [3.2.1] octanes and analogues and combinatorial libraries
    Publication number: 20030176414
    Abstract: The present invention relates to new highly functionalized heterobicycle derivatives of general formula (I), prepared by a process which involves only two steps by using, as starting products, commercially available, or easily prepared, &agr;-amino ketones and &agr;,&bgr;-dihydroxy acids or &agr;-amino-&bgr;-hydroxy acids or &agr;-hydroxy-&bgr;-amino acids or &agr;,&bgr;-dithiol acids derivatives and to libraries containing compounds of formula (I) and to the generation of such combinatorial libraries composed of compounds of formula (I), in individual synthesis, mixture synthesis, split and recombine synthesis and parallel synthesis either in manual or automated fashion.
    Type: Application
    Filed: November 1, 2002
    Publication date: September 18, 2003
    Inventors: Antonio Guarna, Gloria Menchi, Ernesto Giovanni Occhiato, Fabrizio Machetti, Dina Scarpi
  • Benzo[C] quinolizine derivatives, their preparation and use as 5&agr;-reductases inhibitors
    Patent number: 6555549
    Abstract: The present invention refers to benzo[c]quinolizine derivatives of general formula (I) their pharmaceutically acceptable salts or esters, processes for their preparation and pharmaceutical compositions containing them.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: April 29, 2003
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Antonio Guarna, Mario Serio
  • Benzo[c]quinolizine derivatives, their preparation and use as 5&agr;-reductases inhibitors
    Patent number: 6552034
    Abstract: The present invention refers to benzo[c]quinolizine derivatives of general formula (I) their pharmaceutically acceptable salts or esters, processes for their preparation and pharmaceutical compositions containing them.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: April 22, 2003
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Antonio Guarna, Mario Serio