Abstract: The present disclosure provides for, among other things, methods and systems for detecting, diagnosing, predicting, monitoring, screening for, staging, and/or providing survival prognosis for advanced adenoma and/or colorectal cancer using DNA methylation markers. For example, described herein are DNA methylation markers that enable categorization and prognosis evaluation of advanced adenoma (AA) and/or colorectal cancer (CRC) patients with high accuracy from human biospecimens.

Abstract: Systems and methods of synthetic flight performance data generation include obtaining training data corresponding to multiple timeseries of multivariate aircraft performance data of actual aircraft flights. The systems and methods also include performing a training operation of a generative adversarial network that includes a synthetic aircraft performance data generator and a discriminator. After completion of the training operation, the systems and methods also include receiving one or more input parameters, and generating, at the synthetic aircraft performance data generator, one or more timeseries of synthetic aircraft performance data based on the one or more input parameters.

Abstract: This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the humoral or cellular immune response against accompanying antigens. Particularly, this invention provides immunogenic vaccine compositions that comprise peptides, polypeptides or proteins and the aforementioned nanoparticles, which are formed through the dispersion of hydrophobic proteins of the outer membrane complex (OMC) of Neisseria meningitidis in solutions containing fully synthetic variants of the GM3 ganglioside.

Abstract: A device includes a processor configured to obtain flight data of one or more aircraft of an aircraft type. The processor is configured to identify a first portion of the flight data as first phase flight data associated with a first phase of one or more flights of the one or more aircraft, and to apply a first aircraft performance model to the first phase flight data to determine first parameter values. The processor is configured to identify a second portion of the flight data as second phase flight data associated with a second phase of the one or more flights, and to apply the first aircraft performance model to the second phase flight data to determine second parameter values. The processor is configured to generate, based on the first parameter values and the second parameter values, a second aircraft performance model of a particular aircraft of the aircraft type.

Abstract: A method for analysis of an image comprises: receiving (402) the image to be analyzed; processing (404) the image with a machine-learned model, wherein the machine-learned model is configured to predict at least an intrinsic parameter of the image using at least a first variable of the machine-learned model, wherein the first variable defines a relation between a radial distortion of the image and a focal length of the image; and outputting (406) the intrinsic parameter of the image. Also, methods for forming a 3D reconstruction of a scenery, for training a machine-learned model for analysis of an image and for generating a dataset of images for training a machine-learned model are disclosed.

Abstract: A light-emitting array includes a semiconductor LED structure, multiple transparent dielectric bodies, a set of multiple, independent first electrical contacts, and a set of second electrical contacts. The LED structure extends contiguously over the array. The second electrical contacts are in electrical contact with the second semiconductor layer. Each dielectric body protrudes away from the first semiconductor layer and has on its surface an electrically conductive layer in electrical contact with the first semiconductor layer, forming a portion of a corresponding one of the first electrical contacts. Each dielectric body and corresponding first electrical contact define a corresponding discrete, circumscribed pixel region within the contiguous area of the array, each pixel region separate from the others.

Abstract: A nano-structure layer is disclosed. The nano-structure layer includes an array of nano-structure material configured to receive a first light beam at a first angle of incidence and to emit the first light beam at a second angle greater than the first angle, the nano-structure material each having a largest dimension of less than 1000 nm.

Abstract: A control system for an LED array relies on defining a first and a second group of separately addressed LED pixels, with the first group including pixels with an average current no less than the current at a Q point and a second group including pixels with an average current less than the current at a Q point. An amplitude signal provided to the first group of separately addressed LED pixels is selectively modulated, while providing a DC mode 100% duty cycle. An amplitude signal provided to the second group of separately addressed LED pixels is fixed, and a modulated duty cycle is provided.

Abstract: This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the humoral or cellular immune response against accompanying antigens. Particularly, this invention provides immunogenic vaccine compositions that comprise peptides, polypeptides or proteins and the aforementioned nanoparticles, which are formed through the dispersion of hydrophobic proteins of the outer membrane complex (OMC) of Neisseria meningitidis in solutions containing fully synthetic variants of the GM3 ganglioside.

Abstract: A micro light emitting diode (LED) die can include a matrix of micro LEDs with a variety of forward voltages. A method of reducing a number of undriven or under driven uLEDs can include providing, by a power supply, an alternating current voltage (VLED) with a minimum voltage (VMIN) and a maximum voltage (VMAX), VMIN being sufficient to drive a plurality of micro light emitting diodes (uLEDs) of a uLED die using a plurality of uLED drivers, identifying, by a controller coupled to the uLED drivers, a uLED of the plurality of uLEDs with a forward voltage (Vf) greater than VMIN, and altering, by the controller, a time of a rising edge of a pulse width modulation (PWM)-on time of the uLED such that Vf of the uLED is less than VLED for the PWM-on time.

Abstract: A carbonator reactor includes a cylindrical body, a nozzle for supplying a gas stream, inside the carbonator reactor and above the surface of a liquid phase and where the nozzle is located at the top of the reactor body, an inlet, an outlet, means for regulating the temperature and the pressure, a stirring system and at least one baffle regulating the stirring of the liquid phase and the mass transfer of the gas into the liquid surface, at least one impeller having inclined blades that make an angle from 5° to 60° with respect to the vertical axis. The reactor prepares sodium carbonate and has a configuration for the mass transfer of a gas phase in a liquid phase. A method for the preparation of sodium carbonate by means of the carbonator reactor by capturing CO2 in an NaOH aqueous solution, directly on the free surface of the liquid phase.

Abstract: A computer-implemented method is for detecting Global Navigation Satellite System (GNSS) signal spoofing. The method includes storing sample sequences of the predictable part and of the unpredictable part of a GNSS signal at a GNSS receiver. The predictable part includes predictable bits and the unpredictable part includes unpredictable bits. The value of the unpredictable bits from which the unpredictable sample sequences are extracted is verified. A first and a second partial correlation between the unpredictable, respectively predictable, sample sequences and a locally stored GNSS signal replica are computed. A predefined metric from the complex valued partial correlations is calculated. The predefined metric is compared with a predefined threshold value. In a zero-delay replay attack, the spoofer estimates the unpredictable bits introduced by a GNSS authentication protocol and introduces distortion into the signal.

Abstract: A rotor blade for a wind turbine including first and second blade segments extending in opposite directions from a chord-wise joint. The first and second blade segments include one or more shell members and internal support structures coupled to an inner surface of the one or more shell members of the first and second blade segments. The internal support structure of the first blade segment includes a beam structure extending between a first end at the chord-wise joint and a second end such that the beam structure is received by a receiving section of the internal support structure of the second blade segment. The rotor blade includes one or more spacer materials arranged within the first blade segment between an exterior surface of the beam structure and the inner surface of the one or more shell members to reduce a bond gap therebetween.

Abstract: A light-emitting device includes a semiconductor diode structure with one or more light-emitting active layers, an anti-reflection coating on its front surface, and a redirection layer on its back surface. Active-layer output light propagates within the diode structure. The anti-reflection coating on the front surface increases transmission of active-layer output light incident below the critical angle ?c. Active-layer output light incident on the redirection layer at an incidence angle greater than ?c is redirected to propagate toward the front surface at an incidence angle that is less than ?c. Device output light is transmitted by the front surface to propagate in an ambient medium, and includes first and second portions of the active-layer output light incident on the front surface at an incidence angle less than ?c, the first portion without redirection by the redirection layer and the second portion with redirection by the redirection layer.

Abstract: A device comprising a light emitting diode (LED) substrate, and a meta-molecule wavelength converting layer positioned within an emitted light path from the LED substrate, the a meta-molecule wavelength converting layer including a plurality of nanoparticles, the plurality of nanoparticles configured to increase a light path length in the wavelength converting layer.

Abstract: An optical coupling structures are disposed on light output surfaces of semiconductor LEDs of a miniLED or microLED array to facilitate coupling of light emitted by the semiconductor LEDs through the light output surfaces. The optical coupling structures comprise light scattering particles and/or air voids embedded in or coated with a thin layer of a material that has an index of refraction close to or matching the index of refraction of the material forming the light output surface of the semiconductor LEDs.

Abstract: A micro light emitting diode (LED) die can include a matrix of micro LEDs with a variety of forward voltages. A method of reducing a number of undriven or under driven uLEDs can include providing, by a power supply, an alternating current voltage (VLED) with a minimum voltage (VMIN) and a maximum voltage (VMAX), VMIN being sufficient to drive a plurality of micro light emitting diodes (uLEDs) of a uLED die using a plurality of uLED drivers, identifying, by a controller coupled to the uLED drivers, a uLED of the plurality of uLEDs with a forward voltage (Vf) greater than VMIN, and altering, by the controller, a time of a rising edge of a pulse width modulation (PWM)-on time of the uLED such that Vf of the uLED is less than VLED for the PWM-on time.

Abstract: Disclosed is a device for magnetic action on living bodies to perform physiotherapy or stimulating effects on the tissues and internal organs of a human being or an animal to eliminate pain syndromes, stimulate the processes of vital activity and regeneration, and accelerate tissue recovery after invasive effects and injuries. The device comprises an oscillator connected to an inductor including a bifilar coil made as a flat disk. Two coil windings formed as concentrically arranged spirals of adjacent wires of different windings are placed on a dielectric substrate. When attached to the skin surface, the device allows to purposefully target pathogenic areas and organs located at 3-6 cm under the surface, while practically not affecting the tissues located near that surface. Suitable for clinical or home application, the device can be used for relieving pain of various etiologies, treating menstrual syndrome, hemorrhoids, joint diseases, healing injuries, and stimulating cell proliferation.

Abstract: A control system for an LED array relies on defining a first and a second group of separately addressed LED pixels, with the first group including pixels with an average current no less than the current at a Q point and a second group including pixels with an average current less than the current at a Q point. An amplitude signal provided to the first group of separately addressed LED pixels is selectively modulated, while providing a DC mode 100% duty cycle. An amplitude signal provided to the second group of separately addressed LED pixels is fixed, and a modulated duty cycle is provided.

Abstract: A filter insert, a sample vial incorporating a filter insert, a method of using a sample vial containing a filter insert for chemical analysis, and a sample vial kit including a filter insert. The filter insert includes a cylindrical body having a proximal end, a protrusion extending radially from the proximal end of the cylindrical body and configured to set on the open end of a sample vial, a distal end, a cavity extending longitudinally through the cylindrical body from the proximal end to the distal end, and a filter assembly coupled with the distal end of the cylindrical body.