Abstract: A topical composition useful in the treatment of inflammatory skin diseases, including glycomacropeptide (GMP), panthenol, and a cosmetologically acceptable vehicle.

Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.

Abstract: Encoding efficiency for attribute information in point cloud information is improved. A point cloud encoding device includes a subsampling unit configured to preserve chroma signals of some points in a point cloud to be encoded and discard chroma signals of remaining points other than those points, and an attribute information encoding unit configured to encode the chroma signals of those points in the point cloud to be encoded and luma signals of all points.

Abstract: A point cloud coding device includes an interpolation unit configured to perform an interpolation process on a reconstructed point cloud of a coded frame with respect to attribute information in point cloud information and generating a reference frame of fractional precision, a motion estimation unit configured to perform motion estimation between the reference frame of fractional precision and the frame of integer precision to generate motion information, a prediction unit configured to generate a predicted value on the basis of the motion information, and an entropy coding unit configured to entropy-code the difference between a point cloud of the frame and the predicted value.

Abstract: The present invention provides a method for encoding a video signal based on an Edge Adaptive Graph-Based Transform (EA-GBT) including detecting a step edge or a ramp edge from a residual signal; generating a graph signal based on at least one of the step edge or the ramp edge; obtaining an EA-GBT coefficient by performing the EA-GBT for the graph signal; quantizing the EA-GBT coefficient; and entropy-encoding the quantized EA-GBT coefficient.

Abstract: The present invention relates to compounds of Formula (Ia) or pharmaceutically acceptable salts, hydrates, solvates, clathrates, polymorphs, stereoisomers thereof. It further discloses a pharmaceutical composition comprising compounds of Formula (Ia) and the use of compounds of Formula (Ib), in particular for the use in the treatment of diseases or disorders wherein disrupting Rad51-BRCA2 interaction is beneficial.

Abstract: The present invention provides a method for encoding a video signal on the basis of a graph-based separable transform (GBST), the method comprising the steps of: generating an incidence matrix representing a line graph; training a sample covariance matrix for rows and columns from the rows and columns of a residual signal; calculating a graph Laplacian matrix for rows and columns on the basis of the incidence matrix and the sample covariance matrix for rows and columns; and obtaining a GBST by performing eigen decomposition of the graph Laplacian matrix for rows and columns.

Abstract: A diagnostic system is provided for classifying a soft tissue condition within a region of interest of a subject. The diagnostic system comprises a spectrometer system configured to irradiate a soft tissue within a region of interest of a subject, and configured to generate spectral data by acquiring at least a portion of the reflected or emitted light from the region of interest. The diagnostic system further comprises a thermal detection system including at least one thermal sensor that is configured to acquire thermal detection data from the region of interest. A computer system is then used to build a classification model based on input thermal detection and spectral data. The classification model is then applied to an unknown soft tissue condition to classify the condition (e.g., classifying cellulitis from pseudocellulitis).

Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.

Abstract: The present invention relates to a compound of Formula la, lb and Ic, (Formula Ia) a pharmaceutical composition comprising the same and their use in the treatment or prevention of pathological conditions associated to depolarizing GABAergic transmission including, for example, Down syndrome and autism.

Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.

Abstract: The present invention provides a method for encoding a video signal on the basis of a graph-based separable transform (GBST), the method comprising the steps of: generating an incidence matrix representing a line graph; training a sample covariance matrix for rows and columns from the rows and columns of a residual signal; calculating a graph Laplacian matrix for rows and columns on the basis of the incidence matrix and the sample covariance matrix for rows and columns; and obtaining a GBST by performing eigen decomposition of the graph Laplacian matrix for rows and columns.

Abstract: The present invention provides a method for encoding a video signal based on an Edge Adaptive Graph-Based Transform (EA-GBT) including detecting a step edge or a ramp edge from a residual signal; generating a graph signal based on at least one of the step edge or the ramp edge; obtaining an EA-GBT coefficient by performing the EA-GBT for the graph signal; quantizing the EA-GBT coefficient; and entropy-encoding the quantized EA-GBT coefficient.

Abstract: The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines of Formula (I) that function as type II topoisomerase inhibitors and their use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4-amino-2-pyrido bicyclic pyrimidines of Formula (I).

Abstract: A method for encoding a raw lenselet image includes a receiving phase, wherein at least a portion of a raw lenselet image is received, the image including a plurality of macro-pixels, each macro-pixel having pixels corresponding to a specific view angle for the same point of a scene, and an output phase, wherein a bitstream having at least a portion of an encoded lenselet image is outputted. The method has an image transform phase, wherein the pixels of said raw lenselet image are spatially displaced in a transformed multi-color image having a larger number of columns and rows with respect to the received raw lenselet image, wherein dummy pixels having undefined value are inserted into the raw lenselet image and wherein the displacement is performed so as to put the estimated center location of each macro-pixel onto integer pixel locations.

Abstract: A decision tree model is generated from sample data. A visualization system may automatically prune the decision tree model based on characteristics of nodes or branches in the decision tree or based on artifacts associated with model generation. For example, only nodes or questions in the decision tree receiving a largest amount of the sample data may be displayed in the decision tree. The nodes also may be displayed in a manner to more readily identify associated fields or metrics. For example, the nodes may be displayed in different colors and the colors may be associated with different node questions or answers.

Abstract: The present invention provides a method for encoding a video signal on the basis of a graph-based lifting transform (GBLT), comprising the steps of: detecting an edge from an intra residual signal; generating a graph on the basis of the detected edge, wherein the graph includes a node and a weight link; acquiring a GBLT coefficient by performing the GBLT for the graph; quantizing the GBLT coefficient; and entropy-encoding the quantized GBLT coefficient, wherein the GBLT includes a partitioning step, a prediction step, and an update step.

Abstract: The present invention provides a method for encoding a video signal by using a single optimized graph, comprising the steps of: obtaining a residual block; generating graphs from the residual block; generating an optimized graph and an optimized transform by combining the graphs, wherein the graphs are combined on the basis of an optimization step; and performing a transform for the residual block on the basis of the optimized graph and the optimized transform.

Abstract: A diagnostic system is provided for classifying a soft tissue condition within a region of interest of a subject. The diagnostic system comprises a spectrometer system configured to irradiate a soft tissue within a region of interest of a subject, and configured to generate spectral data by acquiring at least a portion of the reflected or emitted light from the region of interest. The diagnostic system further comprises a thermal detection system including at least one thermal sensor that is configured to acquire thermal detection data from the region of interest. A computer system is then used to build a classification model based on input thermal detection and spectral data. The classification model is then applied to an unknown soft tissue condition to classify the condition (e.g., classifying cellulitis from pseudocellulitis).

Abstract: A method for encoding a raw lenselet image includes a receiving phase, wherein at least a portion of a raw lenselet image is received, the image including a plurality of macro-pixels, each macro-pixel having pixels corresponding to a specific view angle for the same point of a scene, and an output phase, wherein a bitstream having at least a portion of an encoded lenselet image is outputted. The method has an image transform phase, wherein the pixels of said raw lenselet image are spatially displaced in a transformed multi-color image having a larger number of columns and rows with respect to the received raw lenselet image, wherein dummy pixels having undefined value are inserted into the raw lenselet image and wherein the displacement is performed so as to put the estimated center location of each macro-pixel onto integer pixel locations.