Abstract: Methods of administering isolated anti-CD38 antibodies in combination with lenalidomide or pomobdomide, and dexamethasone and, optionally, bortezomib, for the treatment of multiple myeloma.

Abstract: The present invention relates to novel small molecules of Formulas I, II, III, Ilia, Illb, and IV and pharmaceutically acceptable salts thereof, as well as the preparation and the use thereof.

Abstract: The present description relates to a plant cutting device for cutting or cloning a plant, and housing the plant for growth. The plant cutting device generally comprises two compartments that are operatively connected together and displaceable from an open position to a closed position defining an enclosure, a cutter mounted within at least one of the compartments and configured to cut a plant part when the first and second compartments are displaced to the closed position, a cut end of the plant part being accommodated within the enclosure; and a growth medium disposed in the first compartment and/or the second compartment for contacting the cut end of the plant part allowing for the growth of the plant.

Abstract: Methods of administering isolated anti-CD38 antibodies subcutaneously are disclosed. The methods provide an effective treatment for autoimmune diseases and cancers, including hematologic diseases. Also disclosed are unit dosage forms for the anti-CD38 antibodies.

Abstract: A method of measuring Gadd45? expression comprising the step of measuring Gadd45? expression levels in a sample of cells, for example CD 138 expressing cells, obtained from a subject known to have or suspected of having a haematological malignancy. Expression levels may be used in diagnosis, for example of multiple myeloma, in providing a prognosis, for example in a patient having multiple myeloma or in guiding selection of an appropriate treatment agent, especially a treatment agent comprising Gadd45? and or MKK7 inhibitors. Also datasets comprising measured expression levels from multiple subjects.

Abstract: The present invention relates to new oxazolidinone compounds of general formula (I) having antibiotic activity even against multiresistant bacterial strains (I).

Abstract: The present invention relates to novel oxazolidinone compounds of general formula (I) having antibiotic activity also against multiresistant bacterial strains.

Abstract: The present invention provides for a demulsifying composition comprising a blend of a) an emulsion; and b) a demulsifying-effective amount of a silicon containing co-polymer. The present invention also provides for a method for separating emulsions using the demulsifying composition discussed.

Abstract: The present invention relates to new oxazolidinone compounds of general formula (I) having antibiotic activity even against multiresistant bacterial strains (I).

Abstract: A composition includes a non-crosslinked reaction product of an oxirane or oxetane compound (I) comprising at least two oxirane or oxetane groups; a compound (II) comprising silicon and one or more amino groups; and optionally a polyamine (III); and a secondary amine (IV).

Abstract: The present invention is related to the preparation and use of moderately cross-linked (chin-extended), reverse (or “inverted”) surfactants, wherein the reverse surfactants comprise a polyether backbone with oligomeric or polymeric silicon-containing substitutions along the backbone. The present invention further describes crosslinked versions of the inverted surfactants, reaction products of alkenyl (allyl, vinyl, methallyl) functional copolymers (polyethers), silicone hydrides and cross-linking agents, which may be optionally reacted with water to react the remaining alkoxy groups. The crosslinking agent contains either SiH or Si-alkoxy groups or both. The compounds of the present invention exhibit only moderate cross-linking in order to be soluble or dispersible in appropriate solvents.

Abstract: There is provided herein a demulsifying composition comprising at least one polyorganosiloxane compound having the general formula (I): M1aM2bD1cD2dT1eT2fQg??(I) wherein: M1=R1R2R3SiO1/2, M2=R4R5RLSiO1/2, D1=R6R7SiO2/2, D2=R8RLSiO2/2, T1=R9SiO3/2, T2=RLSiO3/2, Q=SiO4/2, where R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each independently chosen from monovalent alkyl, aryl or aralkyl hydrocarbon radicals, or chosen from RP; RP is a monovalent polyether radical independently of the general formula (II): —(CnH2n)—O—(C2H4O)o—(C3H6O)p—(C4H8O)q—R10??(II) RL is a monovalent radical independently chosen from the general formula (III): —X—O—(C2H4O)r—(C3H6O)s—(C4H8O)t—{C(O)CuH2uO}v—R11??(III) There is also provided herein a method for separating emulsions comprising combining the components of the demulsification composition into a mixture; allowing the mixture to separate into at least two phases and separating said at least two phases from each other.

Abstract: A method of measuring Gadd45? expression comprising the step of measuring Gadd45? expression levels in a sample of cells, for example CD 138 expressing cells, obtained from a subject known to have or suspected of having a haematological malignancy. Expression levels may be used in diagnosis, for example of multiple myeloma, in providing a prognosis, for example in a patient having multiple myeloma or in guiding selection of an appropriate treatment agent, especially a treatment agent comprising Gadd45? and or MKK7 inhibitors. Also datasets comprising measured expression levels from multiple subjects.

Abstract: The present invention provides for a demulsifying composition comprising the reaction product of an oxirane or oxetane compound (I) comprising at least two oxirane or oxetane groups; a compound (II) comprising silicon and one or more amino groups; and optionally a polyamine (III); and a secondary amine (IV).

Abstract: There is provided herein a demulsifying composition comprising at least one polyorganosiloxane compound having the general formula (I): M1aM2bD1cD2dT1eT2fQg??(I) wherein: M1=R1R2R3SiO1/2, M2=R4R5RLSiO1/2, D1=R6R7SiO2/2, D2=R8RLSiO2/2, T1=R9SiO3/2, T2=RLSiO3/2, Q=SiO4/2, where R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each independently chosen from monovalent alkyl, aryl or aralkyl hydrocarbon radicals, or chosen from RP; RP is a monovalent polyether radical independently of the general formula (II): —(CnH2n)—O—(C2H4O)o—(C3H6O)p—(C4H8O)q—R10??(II) RL is a monovalent radical independently chosen from the general formula (III): —X—O—(C2H4O)r—(C3H6O)s—(C4H8O)t—{C(O)CuH2uO}v—R11??(III). There is also provided herein a method for separating emulsions comprising combining the components of the demulsification composition into a mixture; allowing the mixture to separate into at least two phases and separating said at least two phases from each other.

Abstract: A composition includes a non-crosslinked reaction product of an oxirane or oxetane compound (I) comprising at least two oxirane or oxetane groups; a compound (II) comprising silicon and one or more amino groups; and optionally a polyamine (III); and a secondary amine (IV).

Abstract: The present invention provides for a demulsifying composition comprising a blend of a) an emulsion; and b) a demulsifying-effective amount of a non-crosslinked silicon polyether. The present invention also provides for a method for separating emulsions using the demulsifying composition discussed.

Abstract: The present invention provides a non-crosslinked silicon polyether composition comprising at least one compound with the following formula; [(R1O)(C2H4O)a(C3H6O)b(C4H8O)c]dR2(R3)e wherein R1 is a monovalent radical defined as MgMAhMBiMHjMEkDlDHmDEnToTHpTEqQr M=R4R5R6SiO1/2; MA=R7R8R9SiR10; MB=[(R11R12R13Si)sR14]tSi(R15)u(R16)vR17 MH=R18Si(R19)(R20)O1/2; ME=R21R22RESiO1/2; D=R23R24SiO2/2; DH=R25Si(R26)O2/2; DE=R27RESiO2/2; T=R28SiO3/2; TH=R29SiO3/2; TE=RESiO2/2; and Q=SiO4/2; R2 and R14 are polyvalent linear or branched; R3 is —(C2H4O)(C3H6O)b(C4H8O)c—R30 or R1; R30 is a monovalent saturated; R4, R5, R6, R7, R8, R9, R11, R12, R13, R15, R16, R19, R20, R21, R22, R23, R24, R26, R27, and, R28 are monovalent hydrocarbon radicals having from 1 to about 10 carbons; R10, R17, R18, R25 and R29 are divalent hydrocarbon radicals having 1 to about 25 carbons; RE is —R32—(C2H4O)a(C3H6O)b(C4H8O)c—R33; R32 is a divalent hydrocarbon radical having 1 to about 60 carbons; R33 is a monovalent hydrocarbon radical having 1

Abstract: The present invention provides for a demulsifying composition comprising a blend of a) an emulsion; and b) a demulsifying-effective amount of a silicon containing co-polymer. The present invention also provides for a method for separating emulsions using the demulsifying composition discussed.

Abstract: The present invention provides a non-crosslinked silicon polyether composition comprising at least one compound with the following formula; [(R1O)(C2H4O)a(C3H6O)b(C4H8O)c]dR2(R3)e wherein R1 is a monovalent radical defined as MgMAhMBiMHjMEkDlDHmDEnToTHpTEqQr M=R4R5R6SiO1/2; MA=R7R8R9SiR10; MB=[(R11R12R13Si)sR14]tSi(R15)u(R16)vR17 MH=R18Si(R19)(R20)O1/2; ME=R21R22RESiO1/2; D=R23R24SiO2/2; DH=R25Si(R26)O2/2; DE=R27RESiO2/2; T=R28SiO3/2; TH=R29SiO3/2; TE=RESiO2/2; and Q=SiO4/2; R2 and R14 are polyvalent linear or branched; R3 is —(C2H4O)(C3H6O)b(C4H8O)c—R30 or R1; R30 is a monovalent saturated; R4, R5, R6, R7, R8, R9, R11, R12, R13, R15, R16, R19, R20, R21, R22, R23, R24, R26, R27, and, R28 are monovalent hydrocarbon radicals having from 1 to about 10 carbons; R10, R17, R18, R25 and R29 are divalent hydrocarbon radicals having 1 to about 25 carbons; RE is —R32—(C2H4O)a(C3H6O)b(C4H8O)c—R33; R32 is a divalent hydrocarbon radical having 1 to about 60 carbons; R33 is a monovalent hydrocarbon radical having