Abstract: The present disclosure relates to methods for recellularization of valves in valve-bearing veins. This method is useful for producing an allogeneic venous valve, wherein a donor valve-bearing vein is decellularized and then recellularized using whole blood or bone marrow stem cells. The allogeneic valves produced by the methods disclosed herein are advantageous for implantation, transplantation, or grafting into patients with vascular diseases.

Abstract: A device and method for intravascular dissection of a body lumen, and particularly a blood vessel wall, is disclosed herein. One aspect of the present technology, for example, is directed toward a tubular elongated member having a lumen therethrough, wherein the elongated member includes a distal region configured to be positioned within a blood vessel wall. The distal region can include an angled distal face having a distal-most edge configured to puncture the vessel wall and a proximal-most edge. The member can include an exit port fluidly coupled to the lumen, and positioned along the distal face between the distal-most edge and the proximal-most edge. A central longitudinal axis of the exit port can be offset from a central longitudinal axis of the elongated member such that the exit port is closer to the distal-most edge than the proximal-most edge.

Abstract: A device and method for intravascular dissection of a body lumen, and particularly a blood vessel wall, is disclosed herein. One aspect of the present technology, for example, is directed toward a tubular elongated member having a lumen therethrough, wherein the elongated member includes a distal region configured to be positioned within a blood vessel wall. The distal region can include an angled distal face having a distal-most edge configured to puncture the vessel wall and a proximal-most edge. The member can include an exit port fluidly coupled to the lumen, and positioned along the distal face between the distal-most edge and the proximal-most edge. A central longitudinal axis of the exit port can be offset from a central longitudinal axis of the elongated member such that the exit port is closer to the distal-most edge than the proximal-most edge.

Abstract: The present disclosure relates to methods for recellularization of valves in valve-bearing veins. This method is useful for producing an allogeneic venous valve, wherein a donor valve-bearing vein is decellularized and then recelluiarized using whole blood or bone marrow stem cells. The allogeneic valves produced by the methods disclosed herein are advantageous for implantation, transplantation, or grafting into patients with vascular diseases.

Abstract: A device and method for intravascular dissection of a body lumen, and particularly a blood vessel wall, is disclosed herein. One aspect of the present technology, for example, is directed toward a tubular elongated member having a lumen therethrough, wherein the elongated member includes a distal region configured to be positioned within a blood vessel wall. The distal region can include an angled distal face having a distal-most edge configured to puncture the vessel wall and a proximal-most edge. The member can include an exit port fluidly coupled to the lumen, and positioned along the distal face between the distal-most edge and the proximal-most edge. A central longitudinal axis of the exit port can he offset from a central longitudinal axis of the elongated member such that the exit port is closer to the distal-most edge than the proximal-most edge.

Abstract: A device and method for intravascular dissection of a body lumen, and particularly a blood vessel wall, is disclosed herein. One aspect of the present technology, for example, is directed toward a tubular elongated member having a lumen therethrough, wherein the elongated member includes a distal region configured to be positioned within a blood vessel wall. The distal region can include an angled distal face having a distal-most edge configured to puncture the vessel wall and a proximal-most edge. The member can include an exit port fluidly coupled to the lumen, and positioned along the distal face between the distal-most edge and the proximal-most edge. A central longitudinal axis of the exit port can be offset from a central longitudinal axis of the elongated member such that the exit port is closer to the distal-most edge than the proximal-most edge.

Abstract: A device and method for intravascular dissection of a body lumen, and particularly a blood vessel wall, is disclosed herein. One aspect of the present technology, for example, is directed toward a tubular elongated member having a lumen therethrough, wherein the elongated member includes a distal region configured to be positioned within a blood vessel wall. The distal region can include an angled distal face having a distal-most edge configured to puncture the vessel wall and a proximal-most edge. The member can include an exit port fluidly coupled to the lumen, and positioned along the distal face between the distal-most edge and the proximal-most edge. A central longitudinal axis of the exit port can be offset from a central longitudinal axis of the elongated member such that the exit port is closer to the distal-most edge than the proximal-most edge.

Abstract: A system, method and computer program product for managing a plurality of contact options. A first communication device having a first user receives contact options for communicating with a second user. Each contact option specifies a communications modality, addressing information and selection criteria. Selection criteria may include need-to-know groups, times of day and priorities. One of the contact options is automatically selected based on the selection criteria. A communication session is initiated with the second user according to the communications modality and the addressing information specified in the selected contact option.

Abstract: A method and system for patient optical fixation are disclosed. One embodiment of the system comprises: a light source operable to provide a fixation light beam; a filter optically coupled to the light source and operable to attenuate the fixation light beam to provide an apodized light beam, wherein the apodized light beam comprises a more attenuated portion and a less attenuated portion; and a viewer, operable to receive a reflected fine align beam and a reflected coarse align beam from a fixation target. The light source can be, for example, a laser, a light emitting diode or a laser diode. The filter can be a neutral density (“ND”) filter, comprising: an aperture through which a first portion of the fixation light beam can pass unattenuated by the ND filter to form the less attenuated portion of the apodized light beam; and a filter region for attenuating a second portion of the fixation light beam to form the more attenuated portion of the apodized light beam.

Abstract: A method and system for patient optical fixation are disclosed. One embodiment of the system comprises: a light source operable to provide a fixation light beam; a filter optically coupled to the light source and operable to attenuate the fixation light beam to provide an apodized light beam, wherein the apodized light beam comprises a more attenuated portion and a less attenuated portion; and a viewer, operable to receive a reflected fine align beam and a reflected coarse align beam from a fixation target. The light source can be, for example, a laser, a light emitting diode or a laser diode. The filter can be a neutral density (“ND”) filter, comprising: an aperture through which a first portion of the fixation light beam can pass unattenuated by the ND filter to form the less attenuated portion of the apodized light beam; and a filter region for attenuating a second portion of the fixation light beam to form the more attenuated portion of the apodized light beam.