Abstract: A system (40) for diagnosis and staging of early stages of cancer in the tissue of a patient is provided. The system—is configured to combine information from a Polarized Light Scattering Spectroscopy measurement (70) having a first probe depth, and a Differential Path Length Spectroscopy measurement (60) having a second probe depth, wherein the second probe depth is set larger than' the first probe depth. By comparing the results of the Polarized Light Scattering Spectroscopy and Differential Path Length Spectroscopy measurements early stages of cancer, such as dysplasia may be detected. Also hyperplasia, carcinoma in situ, and carcinoma may be detected. A computer-readable medium, method and use are also provided.

Abstract: The invention relates to a multivariate calibration which can be used when the optical system used for that method does not comprise a multi-channel detector such as a CCD sensor or a line array of photodiodes. An optical system without a multi-channel detector doesn't allow to carry out preprocessing steps. Thus there is the need to carry out these preprocessing steps in another way. It is suggested to partially replace the preprocessing step by a measurement of the optical signal, whereby the measurement comprises transmitting or reflecting the optical signal by an optical element, thereby weighing the optical signal by a spectral weighing function. The advantage of the invention is to teach how such an optical system without a bulky and expensive CCD sensor can be used to carry out a multivariate calibration and preprocessing steps.

Abstract: The invention relates to a method and device for analyzing a tissue (70), which comprises: —irradiating the tissue (70) with light focused on a focal region (40); —collecting light coming back from the focal region (40) into a first detection device (100A), the first detection device (100A) being arranged to only collect the light coming back from the focal region (40), on a first detection area (140A), by confocal spectroscopy, in order to generate a first signal, containing information on an optical property of the tissue (70); —collecting light, scattered from the focal region (40) to at least a second region (60), coming back from the second region (60), into a second detection device (100B), the second detection device (100B) being arranged to only collect the light coming back from the second region (60), on a second detection area (140B), in order to generate a second signal, —using the first and second signals in order to get information on the scattering and/or absorption coefficients of the tissue (

Abstract: The invention relates to a method and device for analyzing a tissue (70), which comprises: —irradiating the tissue (70) with light focused on a focal region (40); —collecting light coming back from the focal region (40) into a first detection device (100A), the first detection device (100A) being arranged to only collect the light coming back from the focal region (40), on a first detection area (140A), by confocal spectroscopy, in order to generate a first signal, containing information on an optical property of the tissue (70); —collecting light, scattered from the focal region (40) to at least a second region (60), coming back from the second region (60), into a second detection device (100B), the second detection device (100B) being arranged to only collect the light coming back from the second region (60), on a second detection area (140B), in order to generate a second signal, —using the first and second signals in order to get information on the scattering and/or absorption coefficients of the tissue (

Abstract: The invention relates to a multivariate calibration which can be used when the optical system used for that method does not comprise a multi-channel detector such as a CCD sensor or a line array of photodiodes. An optical system without a multi-channel detector doesn't allow to carry out preprocessing steps. Thus there is the need to carry out these preprocessing steps in another way. It is suggested to partially replace the preprocessing step by a measurement of the optical signal, whereby the measurement comprises transmitting or reflecting the optical signal by an optical element, thereby weighing the optical signal by a spectral weighing function. The advantage of the invention is to teach how such an optical system without a bulky and expensive CCD sensor can be used to carry out a multivariate calibration and preprocessing steps.

Abstract: A non-invasive system and method for measuring skin hydration of a subject comprising a thermistor (7) used in transient mode to obtain a measurement of the thermal conductivity of the skin of the subject and a processor (8) for determining a skin hydration value from the thermal conductivity measurement. The system for measuring skin hydration may be comprised in a non-invasive system for detecting blood analyte concentration, preferably glucose, including a spectroscopic device having e.g. an infrared source (2) which generates infrared beam (3) and detector (6) for detecting transmitted radiation through portion 1 (e.g. finger) of a subject. The system may also include skin hydrator (9) which moisturises the skin connected in a control loop to the system for measuring skin hydration. The system for detecting blood analyte concentration may include a photoacoustic device or a metabolic heat conformation device.

Abstract: A system and method for non-invasive measurement of glucose concentration in a live subject including a thermal emission spectroscopy (TES) device 10, an optical coherence tomography (OCT) device 20 or near infrared diffuse reflectance (NIDR) device. The TES 10 generates a signal indicative of the absorbtion of glucose, from which the blood glucose concentration is determined and the OCT device 20 generates a signal indicative of the scattering coefficient of a portion of the live subject, from which the blood glucose concentration is determined. The signals generated by the TES and OCT devices along with signals generated by sensors for measuring the body heat and surface temperature of the subject are used in the metabolic heat conformation (MHC) method of determining blood glucose concentration. The system may include a photoacoustic sensor for generating a signal indicative of thermo-elastic skin properties from which the blood glucose concentration is also determined.

Abstract: The present invention provides a spectroscopic apparatus, a method and a computer program product for determining the concentration of an analyte of a fluid that flows through a capillary vessel of a biological sample. The spectroscopic apparatus makes use of an imaging system for determining the position of at least one biosensing substrate that has been implanted into the biological sample in the proximity of the capillary vessel but outside the capillary vessel. The biosensing substrate is capable of inducing surface-enhanced spectroscopic effects and is preferably adapted to reversibly and selectively bind a certain analyte or molecule of the fluid, to which the vessel wall of the capillary vessel is at least semi-permeable.