Abstract: A method is disclosed of purifying a recycled or renewable organic material, wherein the recycled or renewable organic material contains one or more impurities selected from a group consisting of silicon compounds, phosphorous, Cl and sterols. Exemplary embodiments include (a) providing the recycled or renewable organic material; (c) heat treating the recycled or renewable organic material at 100 to 450° C.; and (f) hydrotreating the heat treated recycled or renewable organic material in a presence of a hydrotreating catalyst; to obtain purified hydrotreated recycled or renewable organic material.

Abstract: The invention relates to antisense oligonucleotides that are capable of bringing about specific editing of a target nucleotide (adenosine) in a target RNA sequence in a eukaryotic cell, wherein said oligonucleotide does not, in itself, form an intramolecular hairpin or stem-loop structure, and wherein said oligonucleotide comprises a non-complementary nucleotide in a position opposite to the nucleotide to be edited in the target RNA sequence.

Abstract: The invention relates to single-stranded RNA editing antisense oligonucleotides (AONs) for binding to a target RNA molecule for deaminating a target nucleotide, preferably an adenosine, present in the target RNA molecule and recruiting, in a cell, preferably a human cell, an enzyme with nucleotide deamination activity, preferably an ADAR enzyme, to deaminate the target nucleotide in the target RNA molecule. The AONs carry at least one methylphosphonate-modified internucleosidic linkage on a position that would render the AON more stable in comparison to an AON not carrying that methylphosphonate modification at that position.

Abstract: The invention relates to double stranded oligonucleotide complexes comprising an antisense oligonucleotide (AON) and a complementary sense oligonucleotide (SON), for use in the deamination of a target adenosine in a sense target RNA sequence in a cell by an ADAR enzyme, wherein at least the nucleotide in the AON that is directly opposite the target adenosine in the target RNA sequence does not have a 2?-O-alkyl modification and the SON comprises nucleotides that are at least complementary to all nucleotides in the AON that do not have a 2?-O-alkyl modification. The invention further relates to methods of RNA editing using the AON/SON complexes of the invention.

Abstract: The invention relates to antisense oligonucleotides that are capable of bringing about specific editing of a target nucleotide (adenosine) in a target RNA sequence in a eukaryotic cell, wherein said oligonucleotide does not, in itself, form an intramolecular hairpin or stem-loop structure, and wherein said oligonucleotide comprises a non-complementary nucleotide in a position opposite to the nucleotide to be edited in the target RNA sequence.

Abstract: The invention relates to antisense oligonucleotides that are capable of bringing about specific editing of a target nucleotide (adenosine) in a target RNA sequence in a eukaryotic cell, wherein said oligonucleotide does not, in itself, form an intramolecular hairpin or stem-loop structure, and wherein said oligonucleotide comprises a non-complementary nucleotide in a position opposite to the nucleotide to be edited in the target RNA sequence.

Abstract: The invention relates to double stranded oligonucleotide complexes comprising an antisense oligonucleotide (AON) and a complementary sense oligonucleotide (SON), for use in the deamination of a target adenosine in a sense target RNA sequence in a cell by an ADAR enzyme, wherein at least the nucleotide in the AON that is directly opposite the target adenosine in the target RNA sequence does not have a 2?-O-alkyl modification and the SON comprises nucleotides that are at least complementary to all nucleotides in the AON that do not have a 2?-O-alkyl modification. The invention further relates to methods of RNA editing using the AON/SON complexes of the invention.

Abstract: The invention relates to antisense oligonucleotides that are capable of bringing about specific editing of a target nucleotide (adenosine) in a target RNA sequence in a eukaryotic cell, wherein said oligonucleotide does not, in itself, form an intramolecular hairpin or stem-loop structure, and wherein said oligonucleotide comprises a non-complementary nucleotide in a position opposite to the nucleotide to be edited in the target RNA sequence.

Abstract: A method for measuring, from a thermal device, temperature, molecular number density, and/or pressure of a gaseous compound as function of distance, the gaseous compound absorbing at least some light. The method comprises generating, for a first wavelength band and a second wavelength band, a pulse sequence comprising a light pulse or light pulses, guiding the pulse sequence into the thermal device, and measuring, as function of time, the intensity of the scattered light at the first wavelength band and at the second wavelength band. The method further comprises determining information indicative of the differential absorption between the two wavelengths bands using measured intensities and determining the temperature, the molecular number density, and/or the pressure of the gaseous compound using the information indicative of the differential absorption between the two wavelengths bands. A thermal system arranged to carry out the method.

Abstract: A method for measuring, from a thermal device, temperature, molecular number density, and/or pressure of a gaseous compound as function of distance, the gaseous compound absorbing at least some light. The method comprises generating, for a first wavelength band and a second wavelength band, a pulse sequence comprising a light pulse or light pulses, guiding the pulse sequence into the thermal device, and measuring, as function of time, the intensity of the scattered light at the first wavelength band and at the second wavelength band. The method further comprises determining information indicative of the differential absorption between the two wavelengths bands using measured intensities and determining the temperature, the molecular number density, and/or the pressure of the gaseous compound using the information indicative of the differential absorption between the two wavelengths bands. A thermal system arranged to carry out the method.